Addressing Weight History to Improve Behavioral Treatments for Bulimia Nervosa

解决体重史以改善神经性贪食症的行为治疗

基本信息

批准号：
8891738
负责人：
ADRIENNE SARAH JUARASCIO
金额：
$ 14.56万
依托单位：
DREXEL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-18 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8891738
关键词：
Abstinence Address Adult Applications Grants Behavior Behavior Therapy Behavior assessment Behavioral Binding Binge Eating Biological Markers Body Weight Bulimia Clinical Clinical Management Clinical Trials Cognitive Therapy Complement Counseling Coupled Data Development Diet Diet Habits Disease Disease remission Distress Eating Eating Behavior Eating Disorders Effectiveness Evaluation Exercise Feedback Fright Funding Goals Gold Grant Height Intervention Intervention Trial Knowledge Leadership Maintenance Manuals Manuscripts Mentored Patient-Oriented Research Career Development Award Mentors Metabolic National Institute of Mental Health Nutritional Outcome Outpatients Pathology Patients Pattern Persons Phase Phase II Clinical Trials Population Positioning Attribute Preparation Prevalence Probability Procedures Quality of life Randomized Recording of previous events Recruitment Activity Research Research Personnel Risk Safety Sampling Shapes Subgroup Supervision Symptoms Techniques Testing Therapeutic Time Training Treatment outcome United States National Institutes of Health Universities Validation Value of Life Weight Weight Gain Weight maintenance regimen Woman Writing base biobehavior career design distress tolerance eating pathology efficacy trial experience improved innovation interest medical complication novel nutritional approach outcome forecast patient oriented research pressure professor psychologic purge response restraint skills standard care success therapy development treatment program weight maintenance willingness

项目摘要

DESCRIPTION (provided by applicant): The current project is a re-submission for a K23 award for Dr. Adrienne Juarascio, an Assistant Research Professor at Drexel University. Dr. Juarascio is establishing herself as an early-career investigator in patient oriented research with a focus on innovative treatment development for eating disorders. In particular, Dr. Juarascio is interested in using experimental therapeutics approaches to improve existing treatments for subgroups who experience minimal improvement from existing treatments. This K23 award will provide Dr. Juarascio with the necessary support to accomplish the following goals: (1) Develop expertise in the mechanisms of existing gold-standard treatments for eating pathology and moderators of response to treatment, (2) attain the skills and knowledge necessary to design, conduct, and evaluate clinical trials in outpatient settings, (3) gain experience with assessment techniques for hypothesized maintenance factors in eating pathology, with a focus on bio-behavioral assessment procedures, (4) build proficiency with multi-level and longitudinal analytic approaches related to clinical trial research, and (5) increase skills related to manuscript preparation, grant writing and management, clinical supervision, and academic leadership. To achieve these goals, Dr. Juarascio has assembled a mentoring team comprised of two co-primary mentors (Dr. Michael Lowe and Dr. Evan Forman), two co-mentors (Dr. Carl Lejuez, and Dr. Matthew Hayes) and two consultants (Dr. Carlos Grilo and Dr. Robert Gallop) with whom she has created a training plan that will provide her with the skills needed to become a successful federally-funded independent investigator. As part of this training plan, Dr. Juarascio will develop and assess a novel treatment (Nutritional Counseling and Acceptance-based Treatment, N-CAAT) for patients with bulimia nervosa (BN) who are high in weight suppression, a factor associated with the development and maintenance of BN symptoms and with poor treatment outcome. The poor outcomes for this sub-group are likely due to the predictable weight gain that occurs once normal eating behavior resumes. Although weight gain can reduce the biobehavioral bind that promotes continued pathology, weight gain can also be distressing and promote continued engagement in maladaptive eating behaviors. Innovative treatments that address core maintenance factors are needed to improve outcome. The proposed project will consist of three phases, with Phase I focusing on the creation of a treatment manual, Phase II pilot testing the manual in a small sample and assessing target engagement, and Phase III testing the feasibility, acceptability, target engagement, and target validation of N-CAAT in a small pilot RCT. The primary study aims will be to evaluate the feasibility of recruitment, randomization, retention, assessment procedures, and implementation of the novel treatment to enhance the probability of success in subsequent RCTs. This research will form the basis of a randomized interventional trial that will be submitted in an R01 grant application before the end of the K23 award.

描述（由应用程序提供）：当前项目是Drexel University助理研究教授Adrienne Juarascio博士的K23奖。 Juarascio博士正在以患者为导向研究的早期研究员建立自己专注于饮食失调的创新治疗开发。特别是，Juarascio博士有兴趣使用实验疗法方法来改善现有治疗方法最小改善的亚组的现有治疗方法。该K23奖将为Juarascio博士提供必要的支持，以实现以下目标：（1）在现有金色标准治疗方法的机制方面建立专业知识，以进行饮食病理学和对治疗的反应的主持人，（2）达到设计，进行，进行和评估临床试验的临床试验，以促进饮食技术的临床试验，（3），（3），（3）生物行为评估程序，（4）通过与临床试验研究相关的多层次和纵向分析方法的熟练程度，以及（5）提高与手稿准备，赠款写作和管理，临床监督和学术领导力相关的技能。为了实现这些目标，Jurascio博士组建了一个心理团队，由两名联合促销导师（Michael Lowe博士和Evan Forman博士）组成，两名合伙人（Carl Lejuez博士和Matthew Hayes博士）和两名顾问（Carlos Grilo博士和Robert Gallop博士）与她创建了一个独立的调查员，以使她成为了一项成功的Federall，以使她成为成功的培训计划。作为该培训计划的一部分，Juarascio博士将针对抑制体重较高的贪食症神经（BN）患者开发和评估一种新的治疗方法（营养咨询和基于验收的治疗，N-CAAT），这是与BN症状的发展和维持以及不良治疗结果相关的因素。该子组的不良结果可能是由于可预测的体重增加而引起的，尽管体重增加可以减少促进持续病理学的生物行为结合，但体重增加也可能令人痛苦，并促进继续参与不良适应性饮食行为。需要针对核心维护因素的创新治疗以改善结果。拟议的项目将由三个阶段组成，第一阶段的重点是创建治疗手册，II阶段试点在少量样本中测试手册并评估目标参与度，以及III期测试在小型飞行员RCT中的可行性，可接受性，目标参与度以及N-CAAT的目标验证。主要研究的目的是评估招募，随机化，保留，评估程序和实施新方法的可行性，以提高随后的RCT中成功的可能性。这项研究将构成一项随机介入试验的基础，该试验将在K23裁决结束之前在R01赠款申请中提交。