Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa

自我调节控制和饮食：神经性贪食症的神经影像学研究

• 批准号: 8544829
• 负责人: Laura A. Berner
• 金额: $ 2.24万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8544829
• 关键词: Affect; Area; Base of the Brain; Behavior; Behavioral; Binge Eating; Brain; Bulimia; Chronic; Classification; Complement; Corpus striatum structure; Data; Development; Diagnostic; Diagnostic and Statistical Manual; Disease; Eating; Eating Disorders; Exhibits; Food; Frequencies; Functional Magnetic Resonance Imaging; Goals; Image; Impairment; Individual; Informal Social Control; Investigation; Link; Liquid substance; Maintenance; Measurement; Measures; Mediating; Mental disorders; Modality; Morphologic artifacts; Motion; National Research Service Awards; Near-Infrared Spectroscopy; Participant; Pathology; Patient Self-Report; Performance; Prefrontal Cortex; Process; Psychopathology; Reporting; Research; Research Training; Risk Factors; Self-control as a personality trait; Severities; Signal Transduction; Stimulus; Symptoms; System; Testing; Training Activity; Validation; Woman; Yogurt; base; behavior measurement; cognitive neuroscience; disorder prevention; experience; functional disability; improved; meetings; neurobehavioral; neuroimaging; neuromechanism; novel; programs; psychosocial; relating to nervous system; research study; response; skills; therapy development

DESCRIPTION (provided by applicant): There is considerable evidence to suggest that individuals with bulimia nervosa (BN) exhibit deficits in self- regulatory control. The brain regios involved in these processes have been identified by functional magnetic resonance imaging (fMRI) studies. However, research directly linking self-regulatory deficits and neural activity to clinically meaningful behaviors in BN is notably lacking, largely because motion artifact precludes measurement with fMRI of neural activity during participant-initiated eating. The proposed Ruth L. Kirschstein National Research Service Award (NRSA) is a two-year program of research and training focused on the neural systems mediating general and eating-related self-regulatory control processes in BN. Functional near- infrared spectroscopy (fNIR), a portable and inexpensive neuroimaging modality, allows for assessment of cortical activity in more ecologically- and clinically-valid settings. The proposed project will examine brain activity during a standard and an eating-related go/no-go task in 35 women meeting provisional DSM-5 diagnostic criteria for BN and 35 matched healthy controls. The project aims first to confirm and cross-validate previous findings. This will include testing the hypotheses that 1) compared to healthy controls, women with BN will demonstrate impaired performance and reduced prefrontal neural activity (as measured by fNIR) during the inhibition of prepotent responses in a standard go/no-go task; 2) among women with BN, the magnitude of activity in prefrontal regions will correlate inversely with self-reported frequency of bulimic behaviors. In a subset of participants (n = 28), the fNIR data for this standard task will be cross-validated using fMRI. The study then aims to extend findings using a novel, go/no-go liquid-meal sipping task and a palatable yogurt shake. The same hypotheses will be tested during this second go/no-go task, which requires inhibition of a prepotent sipping response during "no-go" trials. The results of the proposed study would not only confirm the importance of deficits in prefrontal activation during response inhibition tasks in BN, but extend these previous findings by demonstrating similar, and perhaps more profound, deficiencies in activity during a behavioral task that requires self-regulatory control during eating. Importantly, unlike previous studies that have included only symptom-provocation tasks or general cognitive neuroscience paradigms, the combination of aims allows for distinction of activations related specifically to the inhibition of eating from those related o general response inhibition. This NRSA will provide the applicant with the skills and research experience needed to integrate imaging and behavioral data in the investigation of the neural substrates of BN. The novel integration of neuroimaging with a cognitive neuroscience paradigm and an eating task will elucidate the neurobehavioral connections associated with binge eating and the prefrontal neural mechanisms that may contribute to the development and maintenance of the disorder.

描述（由申请人提供）：有大量证据表明患有神经性贪食症（BN）的人表现出自我调节控制能力的缺陷。功能性磁共振成像（fMRI）研究已经确定了参与这些过程的大脑区域。然而，将自我调节缺陷和神经活动与 BN 中具有临床意义的行为直接联系起来的研究非常缺乏，这主要是因为运动伪影妨碍了在参与者发起进食期间使用功能磁共振成像来测量神经活动。拟议的露丝·基尔施斯坦国家研究服务奖 (NRSA) 是一项为期两年的研究和培训计划，重点关注 BN 中调节一般和与饮食相关的自我调节控制过程的神经系统。功能性近红外光谱（fNIR）是一种便携式且廉价的神经成像方式，可以在更生态和临床有效的环境中评估皮质活动。拟议的项目将检查 35 名符合 BN 临时 DSM-5 诊断标准的女性和 35 名匹配的健康对照者在执行标准任务和与饮食相关的“进行/不进行”任务期间的大脑活动。该项目首先旨在确认并交叉验证之前的发现。这将包括测试以下假设：1）与健康对照组相比，患有 BN 的女性在标准“进行/不进行”任务中抑制优势反应期间，表现出表现受损和前额神经活动减少（通过 fNIR 测量）； 2）在患有BN的女性中，前额叶区域的活动强度与自我报告的暴食行为频率呈负相关。在参与者子集中 (n = 28)，此标准任务的 fNIR 数据将使用 fMRI 进行交叉验证。然后，该研究旨在使用一种新颖的、走/不走流质餐啜饮任务和美味的酸奶奶昔来扩展研究结果。在第二个“进行/不进行”任务中将测试相同的假设，该任务需要在“不进行”试验期间抑制优先的啜饮反应。这项研究的结果不仅证实了 BN 中反应抑制任务期间前额叶激活缺陷的重要性，而且通过证明在需要自我调节的行为任务期间类似的、也许更深刻的活动缺陷来扩展这些先前的发现吃饭时要控制。重要的是，与之前仅包括症状激发任务或一般认知神经科学范式的研究不同，目标的组合允许区分与进食抑制专门相关的激活和与一般反应抑制相关的激活。该 NRSA 将为申请人提供在 BN 神经基质研究中整合成像和行为数据所需的技能和研究经验。神经影像学与认知神经科学范式和饮食任务的新颖整合将阐明与暴食相关的神经行为联系以及可能有助于该疾病的发展和维持的前额叶神经机制。

项目成果

Behavioral management of night eating disorders.

夜间饮食失调的行为管理。

• 发表时间: 2013
• 作者: Berner, Laura A;Allison, Kelly C
• 通讯作者: Allison, Kelly C

The relation of weight suppression and body mass index to symptomatology and treatment response in anorexia nervosa.

体重抑制和体重指数与神经性厌食症症状和治疗反应的关系。

• 发表时间: 2013-08
• 影响因子: 4.6
• 作者: Berner, Laura A;Shaw, Jena A;Witt, Ashley A;Lowe, Michael R
• 通讯作者: Lowe, Michael R

A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior.

对肥胖、食欲激素和摄入行为的功能性神经影像学综述。

• 发表时间: 2014-09
• 影响因子: 2.9
• 作者: Burger, Kyle S;Berner, Laura A
• 通讯作者: Berner, Laura A

Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa.

患有神经性贪食症的女性在抑制进食反应期间改变了前额叶激活。

• 发表时间: 2023-06
• 影响因子: 6.9
• 作者: Berner, Laura A;Winter, Samantha R;Ayaz, Hasan;Shewokis, Patricia A;Izzetoglu, Meltem;Marsh, Rachel;Nasser, Jennifer A;Matteucci, Alyssa J;Lowe, Michael R
• 通讯作者: Lowe, Michael R