Neural Bases of Self-regulatory Control in Bulimia Nervosa

神经性贪食症自我调节控制的神经基础

• 批准号: 9392278
• 负责人: Laura A. Berner
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392278
• 关键词: Adult; Affect; Affective; Age; Anterior; Base of the Brain; Behavior; Behavior Control; Behavioral; Binge Eating; Brain; Bulimia; Chronic; Comorbidity; Complement; Controlled Study; Corpus striatum structure; Data; Development; Disease; Down-Regulation; Eating; Eating Disorders; Emotional; Emotions; Equilibrium; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Habits; Impairment; Impulse Control Disorders; Impulsive Behavior; Individual; Informal Social Control; Intervention; Investigation; Link; Matched Group; Measures; Mediating; Medical; Mental disorders; Modeling; Motor; National Institute of Mental Health; National Research Service Awards; Neurocognitive; Operant Conditioning; Participant; Pathology; Patient Self-Report; Pattern; Performance; Prefrontal Cortex; Process; Psychotherapy; Recurrence; Regulation; Reporting; Research; Research Training; Resistance; Sampling; Self-control as a personality trait; Severities; Strategic Planning; Symptoms; Task Performances; Testing; Training; Training Activity; Vomiting; Woman; base; behavior measurement; brain behavior; cingulate cortex; design; emotion regulation; experience; functional disability; improved; interest; loss of control over eating; motor control; negative affect; neural circuit; neurodevelopment; novel; positive emotional state; programs; public health relevance; purge; relating to nervous system; research study; response; skills; therapy development

 DESCRIPTION (provided by applicant): Recent evidence suggests that impairments in self-regulatory control may contribute to the development and persistence of bulimia nervosa (BN). "Loss of control" over eating and compensatory behaviors in BN may result, in part, from deficits in inhibitory control and associated brain-based dysfunction in corticostriatal circuits. In additin, recent models of BN pathology suggest that impairments in self-regulation of emotion may relate to disorder-specific behaviors. Deficits in the ability to exert self-regulatory control may also allow repeated binge eating and purging to become an entrenched behavioral pattern. Identification and characterization of brain-based abnormalities in BN, which could inform novel interventions that target these abnormalities, is imperative. A main objective of the National Institute of Mental Health Strategic Plan includes promoting discovery of brain-behavior processes that contribute to mental illness. Consistent with this strategic objective and the need to develop new and targeted treatments for BN, the proposed Ruth L. Kirschstein National Research Service Award (NRSA) is a three-year program of research and training focused on the overlapping corticostriatal neural circuits mediating multiple self-regulatory capacities in adult BN. Prior studies of control-related deficits in BN have been limited by their use of a singl task to study a single neurocognitive process. The proposed study assesses, among women with BN (n = 30) and group-matched controls (n = 30), the behavioral and neural determinants of three forms of self-regulation (motor inhibition, emotion regulation, and goal-directed action control) and examines relations among these capacities and BN symptoms. The project combines functional magnetic resonance imaging (fMRI), eating disorder symptom assessment, and well-validated neurocognitive tasks. The project aims to test the hypotheses that: 1) women with BN will demonstrate decreased corticostriatal activation and impaired performance during motor inhibitory control and emotion regulation tasks, 2) women with BN will demonstrate deficient goal-directed control abilities, and 3) BN participants with more severe symptoms will demonstrate the greatest impairments in corticostriatal activation, and a model including self-regulatory abilities in all three domains will best predict BN severity. To our knowledge, this project is the first to examine brain activation during negative and positive emotion regulation in BN and the first to investigate a potential relative imbalance in goal-directed control and habit-based responding in BN. This NRSA will lay groundwork for future investigations of the neural substrates of eating disorders by providing the applicant with the advanced skills and research experience needed to collect, analyze, and interpret fMRI and behavioral data, along with introductory training in neurodevelopment. The project's novel integration of multiple, non-symptom-specific probes of motor, affective, and goal-directed behavioral control within the same sample permits distinction of the relative contributions of these self- regulatory control capacities to BN pathology.

 描述（由申请人提供）：最近的证据表明，自我调节控制的损害可能导致神经性贪食症（BN）的发展和持续，而 BN 对饮食和补偿行为的“失去控制”可能部分是由于。此外，最近的 BN 病理学模型表明，情绪自我调节的障碍可能与特定疾病有关。自我调节控制能力的缺陷可能。 反复暴食和暴饮暴食成为 BN 中根深蒂固的行为模式，这可以为针对这些异常的新干预措施提供信息，这是国家心理健康研究所战略计划的一个主要目标。包括促进发现导致精神疾病的大脑行为过程，符合这一战略目标以及开发新的、有针对性的 BN 治疗方法的需要，拟议的露丝·L·基尔施斯坦国家研究服务奖 (NRSA) 是一项奖励。为期三年的研究和培训计划侧重于介导成人 BN 多种自我调节能力的重叠皮质纹状体神经回路，之前对 BN 控制相关缺陷的研究因使用单一任务来研究单一神经认知过程而受到限制。拟议的研究评估了 BN 女性 (n = 30) 和分组匹配对照组 (n = 30) 中三种自我调节形式（运动抑制、情绪抑制）的行为和神经决定因素。该项目结合了功能磁共振成像 (fMRI)、饮食失调症状评估和经过充分验证的神经认知任务。 ：1) 患有 BN 的女性将表现出皮质纹状体激活减少，并且在运动抑制控制和情绪调节任务中表现受损，2) 患有 BN 的女性将表现出目标导向控制能力不足，以及 3) BN 参与者的症状更严重将表现出皮质纹状体激活的最大损伤，并且包含所有三个领域的自我调节能力的模型将最好地预测 BN 的严重程度，该项目是第一个检查消极和积极情绪调节期间的大脑激活的项目。 BN 是第一个研究 BN 中目标导向控制和基于习惯的反应的潜在相对不平衡的国家，该 NRSA 将为申请人提供所需的高级技能和研究经验，为未来饮食失调神经基质的研究奠定基础。收集、分析和解释功能磁共振成像和行为数据，以及神经发育的入门培训，该项目在同一样本中对运动、情感和目标导向行为控制的多个非症状特异性探针进行了新颖的整合。这些自我调节控制能力对 BN 病理学的相对贡献的区别。