Sleep and Emotion Regulation across Early Childhood

整个幼儿期的睡眠和情绪调节

• 批准号: 8609066
• 负责人: MONIQUE K LEBOURGEOIS
• 金额: $ 39.49万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-26 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8609066
• 关键词: 2 year old; Acute; Address; Adolescence; Adolescent; Adult; Age; Attention; Attenuated; Behavior; Behavioral; Biological; Biology; Brain region; Characteristics; Child; Circadian Rhythms; Cognitive; Conflict (Psychology); Controlled Study; Data; Development; Drowsiness; Electroencephalography; Emotional; Emotions; Health; Heart Rate; Home environment; Homeostasis; Hydrocortisone; Individual; Individual Differences; Intercept; Light; Link; Literature; Measures; Medical; Melatonin; Mental disorders; Moods; Pathway interactions; Performance; Phase; Physiological; Polysomnography; Prevalence; Prevention; Problem behavior; Process; Psychopathology; Recording of previous events; Regulation; Research; Risk; Role; Salivary; Schedule; Sinus Arrhythmia; Sleep; Sleep Deprivation; Societies; Stimulus; Structure; System; Temperament; Time; Wakefulness; base; behavior influence; behavior measurement; biological systems; brain behavior; early childhood; emotion regulation; positive emotional state; respiratory; response; showing emotion; sleep regulation; stressor; time interval; urinary

DESCRIPTION (provided by applicant): This research focuses on the co-development and co-regulation of the sleep and emotion processes during early childhood (ages 2-5 years). The specific aims of this research are (1) to examine the early developmental progression of sleep homeostasis (i.e., accumulation and dissipation); (2) to examine early developmental changes in the circadian process (i.e., phase, amplitude, phase angle of entrainment); and (3) to determine the impact of acute sleep restriction on physiological and behavioral measures of emotion regulation. Given the prevalence of early emotional/behavioral problems (7%-24%) and their stability, identifying factors that may alter pathways to mental illness is critical. Sleep-wake regulation is one such factor. Healthy, normally developing young children (n=40; ages 2-5 years) will participate in four annual 30-day in-home assessments of sleep homeostasis, circadian rhythms, and emotion regulation. Aim 1 addresses developmental changes in the accumulation (build up) and dissipation (decay) of sleep homeostasis. Children are studied while following a strict sleep wake schedule. On five non-consecutive days, the timing of polysomnographic sleep recordings varies as a function of prior wakefulness. EEG spectral power in the slow- wave activity range (.75Hz-4.5Hz) is computed in NREM sleep after 4hrs, 7hrs, 10hrs, 13hrs, and 16hrs of extended wakefulness. Accumulation parameters (time constant, upper asymptote) are estimated by SWA in the first NREM sleep episode of each recording. Dissipation is measured as the time course of SWA during NREM sleep episodes in all-night recordings (13hrs and 16hrs extended wakefulness). Aim 2 addresses developmental changes in circadian measures, including circadian phase [salivary dim-light melatonin onset (DLMO)], urinary melatonin amplitude, and phase angle of entrainment (DLMO-to-bedtime and DLMO-to-wake time intervals). The third aim addresses the effects of sleep restriction on emotion regulation in structured and unstructured home-based contexts. It is hypothesized that sleep restriction will (a) increases negative responsivity; (b) decrease positive responsivity; (c) decrease attention, inhibitory control, and use of adaptive regulation strategies; and (d) heighten physiological responses (respiratory sinus arrhythmia, cortisol reactivity) to emotionally eliciting stimuli/situations

描述（由申请人提供）：本研究的重点是儿童早期（2-5岁）期间睡眠和情感过程的共同开发和共同调节。这项研究的具体目的是（1）检查睡眠体内稳态的早期发育进展（即积累和耗散）； （2）检查昼夜节律过程的早期发展变化（即相位，振幅，夹带相位角）； （3）确定急性睡眠限制对情绪调节的生理和行为度量的影响。鉴于早期情绪/行为问题的流行率（7％-24％）及其稳定性，因此确定可能改变精神疾病途径的因素至关重要。睡眠效果调节就是这样的因素之一。健康的，正常发展的幼儿（n = 40； 2-5岁）将参加四个年度30天的内室内评估，对睡眠体内稳态，昼夜节律和情感调节。 AIM 1解决了睡眠稳态的积累（积累）和耗散（衰减）的发展变化。遵循严格的睡眠唤醒时间表时，对孩子进行了研究。在五天的五天内，多摄像学睡眠记录的时机随着先前的觉醒而变化。慢波活性范围（.75hz-4.5Hz）中的EEG光谱功率在4小时，7小时，10小时，13小时和16小时后在NREM睡眠中计算。在每个记录的第一个NREM睡眠发作中，SWA估算了累积参数（时间常数，上渐近线）。耗散是在全夜录音中（13小时和16小时延长清醒）中NREM睡眠发作期间SWA的时间过程。 AIM 2解决了昼夜节律措施的发展变化，包括昼夜节相[唾液昏暗的褪黑激素发作（DLMO）]，尿褪黑激素幅度和夹带的相位角度（DLMO到床位和DLMO-TO-DLMO-TO-TO-TO-TO-WAKE-WAEKE TIME STICTALS）。第三个目的解决了睡眠限制对结构化和非结构化家庭环境中情绪调节的影响。假设睡眠限制将增加负面反应性； （b）降低阳性反应性； （c）减少注意力，抑制性控制和适应性调节策略的使用； （d）提高生理反应（呼吸窦性心律失常，皮质醇反应性）对情绪引起的刺激/情况

项目成果

Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood.

• DOI: 10.1111/jsr.12427
• 发表时间: 2016-12
• 期刊: Journal of sleep research
• 影响因子: 4.4
• 作者: Kurth S;Lassonde JM;Pierpoint LA;Rusterholz T;Jenni OG;McClain IJ;Achermann P;LeBourgeois MK
• 通讯作者: LeBourgeois MK

Sleep patterns and obesity in childhood.

• DOI: 10.1097/med.0000000000000125
• 发表时间: 2015-02
• 期刊: Current opinion in endocrinology, diabetes, and obesity
• 作者: Miller AL;Lumeng JC;LeBourgeois MK
• 通讯作者: LeBourgeois MK

Spatio-temporal properties of sleep slow waves and implications for development.

• DOI: 10.1016/j.cophys.2020.01.007
• 发表时间: 2020-06
• 期刊: Current opinion in physiology
• 影响因子: 2.5
• 作者: I. Timofeev;S. Schoch;M. LeBourgeois;R. Huber;B. Riedner;S. Kurth

Myelination Is Associated with Processing Speed in Early Childhood: Preliminary Insights.

• DOI: 10.1371/journal.pone.0139897
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chevalier N;Kurth S;Doucette MR;Wiseheart M;Deoni SC;Dean DC 3rd;O'Muircheartaigh J;Blackwell KA;Munakata Y;LeBourgeois MK
• 通讯作者: LeBourgeois MK

Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role?

• DOI: 10.3390/brainsci3041445
• 发表时间: 2013-11-12
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Kurth S;Achermann P;Rusterholz T;Lebourgeois MK
• 通讯作者: Lebourgeois MK