Development of New Photo-Activated Antibacterial Agents

新型光活化抗菌剂的开发

• 批准号: 8878481
• 负责人: Liju Yang
• 金额: $ 34.14万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8878481
• 关键词: Acinetobacter baumannii; Address; Adhesions; Adverse effects; Air; Anti-Bacterial Agents; Antibiotics; Area; Bacillus anthracis; Bacteria; Bacterial Antibiotic Resistance; Bacterial Infections; Benign; Blood Circulation; Carbon; Carbon nanoparticle; Cells; Communicable Diseases; Complex; Cotton Fiber; Development; Disease Outbreaks; Disinfection; Dyes; Effectiveness; Elements; Environment; Escherichia coli O157; Food Supply; Generations; Gram-Positive Bacteria; Growth; Healthcare Systems; Hospitals; Human; Hybrids; Infection; Infectious Agent; Life; Light; Listeria monocytogenes; Medical; Modeling; Modification; Multi-Drug Resistance; Nitric Oxide; Optics; Oxidation-Reduction; Ozone; Performance; Photosensitizing Agents; Phototoxicity; Prevention; Process; Property; Public Health; Quantum Dots; Reactive Oxygen Species; Reproduction spores; Research; Semiconductors; Silver; Societies; Solid; Solutions; Source; Staging; Sunlight; Surface; System; Technology; Testing; Time; Toxic effect; Training; Ultraviolet Rays; Underrepresented Minority; Visible Radiation; Water Supply; absorption; antimicrobial; antimicrobial drug; base; cancer cell; design; disorder prevention; drug development; expectation; experience; foodborne pathogen; graduate student; improved; irradiation; killings; meetings; metal oxide; nano; nanoparticle; nanoscale; pathogen; practical application; public health relevance; research study; resistance mechanism; soft tissue; success; titanium dioxide; undergraduate student; wasting; water treatment

 DESCRIPTION (provided by applicant): Infectious diseases caused by bacterial pathogens are widespread, presenting major challenges to our healthcare systems, from treatment needs to preventions in hospital settings and food and water supplies, and to the global public health in general. Especially, the rise in multidrug resistance among bacterial pathogens has threatened the effective prevention and treatment of bacterial infections. As new resistance mechanisms emerge and spread globally as fast as new drug development, the realm of traditional antibiotics/antimicrobial agents is no longer able to meet society's expectations. This has motivated a global search for alternative antimicrobial strategies. Some of the newly discovered materials and their associated technologies, particularly those may be applied in various stages prior to outbreaks of infection, have shown great potential. Among the most effective are photo-activated antimicrobial agents, especially those responsive to visible light, providing solutions i prevention of bacterial infections across a wide variety of applications. Carbon dots are generally "small carbon nanoparticles with surface passivation". They are known for their broad optical absorption over the entire visible spectrum, and share similar mechanisms with those of typical photosensitizers, which under photo irradiation generate reactive oxygen species (ROS), but extend the photo- activation to visible light, especially for the opportunity to potentially us natural sunlight. Their visible-light photodynamic effect has been demonstrated for the killing of cancer cells. As such the photo toxicity against bacteria in this and other mechanisms is anticipated. Further, the photo toxicity should be mechanistically tunable with dot surface modification and/or doping with other elements for carbon-based hybrid dots. The project aims 1) To Exploit the Visible-Light-Activated Antibacterial Functions of Carbon Dots; and 2) To Develop Carbon-Based Hybrid Nano-Dots for Enhanced Antibacterial Performance. Development of such photochemical antimicrobial technology will address some major challenges in infectious disease prevention and treatment. The research topic and environment will provide excellent opportunities to undergraduate and graduate students, especially those from underrepresented groups, for their contributions to the performance and success of the project and, at the same time, valuable trainings in the interdisciplinary area.

 描述（由适用提供）：细菌病原体引起的传染病广泛，对我们的医疗保健系统提出了主要挑战，从治疗需求到医院环境，食品和供水的预防，以及全球公共卫生 一般的。尤其是，细菌病原体中多药耐药性的升高威胁着细菌感染的有效预防和治疗。随着新的抗药性机制与新药开发一样快，在全球范围内传播，传统抗生素/抗菌剂的领域不再能够满足社会的期望。这促使全球寻找替代性抗菌策略。一些新发现的材料及其相关技术，尤其是在感染爆发之前可能在各个阶段应用的材料，已经显示出巨大的潜力。最有效的是光激活的抗菌剂，尤其是那些对可见光响应的抗微生物剂，从而预防了多种应用中细菌感染的溶液。碳点通常是“具有表面钝化的小碳纳米颗粒”。它们以在整个可见光谱中的广泛光学滥用而闻名，并与典型的光传感器的机制共享相似的机制，在照片照射下会产生活性氧（ROS），但将光激活扩展到可见光，尤其是有机会有可能有可能有潜在的美国天然太阳光线。它们的可见光动力学作用已被证明用于杀死癌细胞。因此，预计在这种机制和其他机制中对细菌的照片毒性。此外，照片的毒性应在机械上可以调节，并通过DOT表面修饰和/或与其他元素一起用于碳基杂种点。该项目的目的是1）利用碳点的可见光激活抗菌功能； 2）开发基于碳的混合纳米点，以增强抗菌性能。这种光化学抗微生物技术的开发将解决预防和治疗的传染病方面的一些主要挑战。研究主题和环境将为本科和研究生，尤其是来自代表性不足的团体的本科生和研究生提供极好的机会，因为它们对项目的绩效和成功做出了贡献，同时又是跨学科领域的宝贵培训。

项目成果

Carbon Dots' Antiviral Functions Against Noroviruses.

• DOI: 10.1038/s41598-017-00675-x
• 发表时间: 2017-03-31
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Dong X;Moyer MM;Yang F;Sun YP;Yang L
• 通讯作者: Yang L

Antibacterial effects of carbon dots in combination with other antimicrobial reagents.

• DOI: 10.1371/journal.pone.0185324
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Dong X;Awak MA;Tomlinson N;Tang Y;Sun YP;Yang L
• 通讯作者: Yang L

Photoexcited State Properties of Carbon Dots from Thermally Induced Functionalization of Carbon Nanoparticles.

碳纳米粒子热诱导功能化产生的碳点的光激发态特性

• DOI: 10.1039/c6tc03666j
• 发表时间: 2016-11-28
• 期刊: Journal of materials chemistry. C
• 作者: Hu Y;Al Awak MM;Yang F;Yan S;Xiong Q;Wang P;Tang Y;Yang L;LeCroy GE;Hou X;Bunker CE;Xu L;Tomlinson N;Sun YP
• 通讯作者: Sun YP

Visible-Light-Activated Bactericidal Functions of Carbon "Quantum" Dots.

• DOI: 10.1021/acsami.6b01765
• 发表时间: 2016-05-04
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Meziani, Mohammed J.;Dong, Xiuli;Zhu, Lu;Jones, Les P.;LeCroy, Gregory E.;Yang, Fan;Wang, Shengyuan;Wang, Ping;Zhao, Yiping;Yang, Liju;Tripp, Ralph A.;Sun, Ya-Ping
• 通讯作者: Sun, Ya-Ping

Dual functional nisin-multi-walled carbon nanotubes coated filters for bacterial capture and inactivation.

• DOI: 10.1186/s13036-015-0018-8
• 发表时间: 2015
• 期刊: Journal of biological engineering
• 影响因子: 5.6
• 作者: Dong X;Yang L
• 通讯作者: Yang L