Climate impact on coastal ecosystem methylmercury: human exposure implications

气候对沿海生态系统甲基汞的影响：人类接触的影响

• 批准号: 8551668
• 负责人: Celia Y Chen
• 金额: $ 36.62万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8551668
• 关键词: Address; Biomass; Carbon; Child; Climate; Complex; Consumption; Data; Ecosystem; Eutrophication; Exposure to; Fisheries; Fishes; Food; Food Webs; Future; Goals; Hazardous Substances; Health; Human; Individual; International; Laboratory Study; Link; Location; Manuscripts; Marines; Mercury; Methylation; Methylmercury Compounds; Mexico; Modeling; Nutrient; Outcome; Oxidation-Reduction; Peer Review; Phytoplankton; Population; Pregnant Women; Production; Publications; Relative (related person); Research; Research Personnel; Review Literature; Risk; Shellfish; Site; Source; Staging; Study models; Techniques; Temperature; Testing; Toxin; Variant; Water; Writing; base; bioaccumulation; climate change; exposed human population; field study; gulf coast; innovation; interest; meetings; public health relevance; tool

DESCRIPTION (provided by applicant) Mercury (Hg) is the third most important contaminant on the CERCLA Priority List of Hazardous Substances (2011) and its organic and toxic form, methyl mercury (MeHg), is a potent toxin with human health effects. Marine fisheries particularly in coastal ecosystems are dominant sources of human exposure to MeHg through consumption of marine fish and shellfish. 48 states in the U.S. have issued advisories against consumption of fish due to MeHg, including coastal advisories for the Atlantic Coast and the Gulf of Mexico. Sub-populations most at risk for exposure include pregnant women and children and subsistence fishers. To date, research on MeHg fate has not investigated the interaction of climate change variables such as temperature and nutrient/carbon loading even though they are likely to have synergistic effects on the formation and transfer of MeHg to the fish and shellfish that humans consume. The investigators therefore propose to examine in detail individual and combined effects of these factors using laboratory and field studies, and through integrative modeling to examine their overall impact on human exposure to MeHg. The following three aims are the basis for their primary hypotheses: Aim 1: Determine the effects of temperature, nutrient and carbon loading on the net MeHg formation in sediments and the associated net inputs of MeHg to the water column in coastal ecosystems. Aim 2: Determine the interactive effects of temperature and nutrient supply/ecosystem eutrophication on bioaccumulation of MeHg by primary producers, and transfer between primary and secondary consumers in estuarine food webs. Aim 3: Predict how climate-induced changes in MeHg bioaccumulation in coastal food webs will increase exposure and risk to sensitive populations. The investigators will apply innovative experimental and field techniques to investigate the interactions between these factors on MeHg fate in estuaries. They will investigate sites in northern and southern latitudes to determine the influence of a natural range of temperatures on MeHg production and bioaccumulation in estuarine ecosystems. Finally, they will use experimental and field data to adapt and parameterize an existing MeHg biogeochemistry and bioaccumulation model to include variation in temperature and nutrient/carbon loading. These tools will allow them to predict the effects of climate change variables on MeHg production and transfer to fish to estimate the net effect of these changes on human exposure.

描述（由申请人提供） 汞（HG）是CERCLA优先级危险物质（2011）及其有机和有毒形式甲基汞（MEHG）的第三大最重要的污染物，是具有人类健康影响的有效毒素。 海洋渔业特别是在沿海生态系统中，是通过食用海洋鱼类和贝类而接触MEHG的主要来源。 美国有48个州发布了反对由于MEHG消费的鱼类的咨询，包括大西洋沿岸和墨西哥湾的沿海咨询。 大人群的暴露风险包括孕妇和儿童以及生存渔民。 迄今为止，对MEHG命运的研究尚未研究气候变化变量（例如温度和养分/碳负荷）的相互作用，即使它们可能对MEHG的形成和转移对人类消耗的鱼类和贝类的形成和转移产生协同作用。因此，研究人员建议使用实验室和现场研究详细检查这些因素的个人和联合效应，并通过综合建模来检查其对人类对MEHG暴露的总体影响。以下三个目标是其主要假设的基础： AIM 1：确定温度，养分和碳负载对沉积物中净MEHG形成的影响，以及MEHG的相关净投入到沿海生态系统中水柱的影响。 目标2：确定温度和养分供应/生态系统富营养化对主要生产者MEHG生物蓄积的互动效果，以及在河口食品网中的初级和二级消费者之间的转移。 AIM 3：预测沿海食品网中MEHG生物蓄积的气候变化将如何增加对敏感人群的风险和风险。 研究人员将采用创新的实验和现场技术来研究这些因素对河口中MEHG命运的相互作用。 他们将调查北部和南部纬度的地点，以确定天然温度对河口生态系统中MEHG生产和生物蓄积的影响。 最后，他们将使用实验和现场数据适应和参数化现有的MEHG生物地球化学和生物蓄积模型，以包括温度和养分/碳负载的变化。这些工具将使他们能够预测气候变化变量对MEHG生产的影响并转移到鱼类，以估计这些变化对人类暴露的净影响。