Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
基本信息
- 批准号:8725601
- 负责人:
- 金额:$ 30.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-17 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAfrican AmericanCase SeriesCharacteristicsClinicalCodeDataDevelopmentDiagnosisDiseaseEnrollmentEnvironmental Risk FactorEpigenetic ProcessEventFertilityGenesGeneticHispanicsMammary Gland ParenchymaMeasurementMethylationMicroRNAsMinority GroupsNeoplasm MetastasisOutcomePatientsPlayPopulationPostmenopausePregnancyPremenopauseProtein AnalysisProteinsRelative RisksResearch PersonnelResearch Project GrantsRiskRisk FactorsRoleTestingTumor MarkersWomanWorkcancer health disparityearly onsetepigenomicsethnic minority populationhigh riskmalignant breast neoplasmparityprogramspromoterpublic health relevanceracial and ethnictumoryoung woman
项目摘要
DESCRIPTION (provided by applicant): Risk of breast cancer (BC) increases in the period immediately following pregnancy. BCs that occur in the post-partum period have more aggressive histopathological features, are more likely to metastasize, and are associated with worse patient outcomes. On average, they also affect younger women and may represent a substantial proportion of early onset breast cancer (EOBC), a phenomenon that disproportionately affects racial/ethnic minority populations, such as Hispanics and African American (AA) women. We propose that pregnancy enhances development of BC in women whose breast tissue is vulnerable to the promotional effects of pregnancy via as yet unknown genetic and/or environmental factors and that this vulnerability explains at least part of the increased risk of EOBC and poor outcomes observed in women with higher fertility. The immediate objective of this research project is to examine epigenetic profiles of BCs that occur in the transient high-risk post-partum period versus those diagnosed outside of this period. Studies will be conducted in BC case series of Hispanic women, a population characterized by high parity. Our specific aims are to: 1) Define the risk factors, tumor sub-types, and clinicopathological characteristics associated with BCs occurring in the post-partum period of increased risk relative to those outside this period in Hispanic women; 2) Test the hypothesis that methylation of specific protein-coding gene promoters is more frequent in tumors that are diagnosed in the post-partum period of increased risk vs. those occurring outside the transient high risk period; and, 3) Test the hypothesis that miRNA genes are more likely to be epigenetically altered in tumors diagnosed in the post-partum period. Results of the proposed work may further elucidate possible mechanisms that play a role in pre-menopausal EOBC, particularly those mechanisms that are temporally related to a recent pregnancy.
描述(由申请人提供):怀孕后的一段时间内患乳腺癌 (BC) 的风险会增加。产后发生的乳腺癌具有更具侵袭性的组织病理学特征,更容易转移,并且与较差的患者预后相关。平均而言,它们也会影响年轻女性,并且可能在早发性乳腺癌 (EOBC) 中占很大比例,这种现象对少数种族/族裔人口的影响尤为严重,例如西班牙裔和非裔美国 (AA) 女性。我们认为,对于乳腺组织易受妊娠促进作用(通过迄今未知的遗传和/或环境因素)影响的女性来说,怀孕会促进 BC 的发展,并且这种脆弱性至少部分解释了 EOBC 风险增加和观察到的不良结果的部分原因。生育能力较高的女性。该研究项目的直接目标是检查在短暂的高风险产后期间发生的 BC 的表观遗传特征与在此期间之外诊断出的 BC 的表观遗传特征。研究将对不列颠哥伦比亚省西班牙裔妇女的病例系列进行,该群体的特征是高生育率。我们的具体目标是: 1) 确定与产后时期发生的 BC 相关的危险因素、肿瘤亚型和临床病理学特征,相对于该时期以外的西班牙裔女性,产后时期发生的 BC 风险增加; 2) 检验以下假设:与在短暂高风险期之外发生的肿瘤相比,在风险增加的产后时期诊断出的肿瘤中特定蛋白质编码基因启动子的甲基化更频繁; 3) 检验以下假设:在产后诊断的肿瘤中,miRNA 基因更有可能发生表观遗传改变。拟议工作的结果可能会进一步阐明在绝经前 EOBC 中发挥作用的可能机制,特别是那些与最近怀孕暂时相关的机制。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reproductive risk factors and breast cancer subtypes: a review of the literature.
- DOI:10.1007/s10549-014-2852-7
- 发表时间:2014-02
- 期刊:
- 影响因子:3.8
- 作者:Anderson, Kristin N.;Schwab, Richard B.;Martinez, Maria Elena
- 通讯作者:Martinez, Maria Elena
Differentially expressed microRNAs in postpartum breast cancer in Hispanic women.
- DOI:10.1371/journal.pone.0124340
- 发表时间:2015
- 期刊:
- 影响因子:3.7
- 作者:Muñoz-Rodríguez JL;Vrba L;Futscher BW;Hu C;Komenaka IK;Meza-Montenegro MM;Gutierrez-Millan LE;Daneri-Navarro A;Thompson PA;Martinez ME
- 通讯作者:Martinez ME
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{{ truncateString('Bernard W FUTSCHER', 18)}}的其他基金
DNA methylation, Liquid Biopsy, and Pancreatic Cancer
DNA 甲基化、液体活检和胰腺癌
- 批准号:
10605291 - 财政年份:2022
- 资助金额:
$ 30.29万 - 项目类别:
DNA methylation, Liquid Biopsy, and Pancreatic Cancer
DNA 甲基化、液体活检和胰腺癌
- 批准号:
10434410 - 财政年份:2022
- 资助金额:
$ 30.29万 - 项目类别:
Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
- 批准号:
8144769 - 财政年份:2010
- 资助金额:
$ 30.29万 - 项目类别:
Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
- 批准号:
8724580 - 财政年份:2010
- 资助金额:
$ 30.29万 - 项目类别:
Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
- 批准号:
8545727 - 财政年份:2010
- 资助金额:
$ 30.29万 - 项目类别:
Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
- 批准号:
8323006 - 财政年份:2010
- 资助金额:
$ 30.29万 - 项目类别:
Epigenetic Features of Pregnancy-Associated Breast Cancer in Hispanic Women
西班牙裔女性妊娠相关乳腺癌的表观遗传特征
- 批准号:
7993973 - 财政年份:2010
- 资助金额:
$ 30.29万 - 项目类别:
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