Core C: Imaging

核心 C：成像

• 批准号: 8740111
• 负责人: MICHAEL I MILLER
• 金额: $ 82.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8740111
• 关键词: Biological Markers; Clinical; Dementia; Image; Imaging Techniques; Impaired cognition; Individual; Magnetic Resonance Imaging; Methodology; Methods; Participant; Pattern; Pittsburgh Compound-B; Positron-Emission Tomography; Procedures; Research Personnel; Risk; Scanning; Work; abstracting; cohort; data sharing; pre-clinical; web site

IMAGING CORE - CORE C: ABSTRACT The Imaging Core (Core C) is responsible for all aspects of image acquisition and analysis. The aims of the Imaging Core are: (1) To facilitate the acquisition of new magnetic resonance imaging (MRI) scans and new Positron Emission Tomography scans, using Pittsburgh Compound B (PiB/PET), for the BIOCARD study participants, and to analyze the newly acquired scans with state-of-the-art methodology; (2) To continue the analysis of the previously acquired MRI scans with both semi-automated and automated methods; (3) To continue to work collaboratively with the other Cores to examine combinations of biomarkers that are predictive of progression and to examine the order and pattern of biomarker change during preclinical AD, including evaluating potential new biomarkers; (4) To share the image files and related clinical information with investigators in the field, via the BIOCARD website, using the approved BIOCARD Study data sharing procedures.

成像核心 - 核心C：抽象 成像核（核心C）负责图像采集和分析的各个方面。目的 成像核心是：（1）促进新磁共振成像（MRI）扫描和新的 正电子发射断层扫描，使用匹兹堡化合物B（PIB/PET）进行生物卡研究 参与者，并使用最先进的方法分析新获得的扫描； （2）继续 通过半自动化和自动化方法分析先前获得的MRI扫描； （3）到 继续与其他核心合作，检查具有预测性的生物标志物的组合 临床前AD期间生物标志物变化的顺序和模式，包括 评估潜在的新生物标志物； （4）与图像文件和相关临床信息共享 通过Biocard网站，该领域的调查人员使用批准的Biocard研究数据共享 程序。