Clinical and Autonomic Effects of Mind-Body Exercise in COPD

身心锻炼对慢性阻塞性肺病的临床和自主神经作用

基本信息

批准号：
8533728
负责人：
GLORIA Y YEH
金额：
$ 60.03万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8533728
关键词：
Activities of Daily Living Adherence Aerobic Exercise Attention Biological Markers Breathing Breathing Exercises C-reactive protein California Cardiac Cardiopulmonary Cardiovascular system Cause of Death Chinese People Chronic Chronic Obstructive Airway Disease Clinic Clinical Clinical Treatment Data Disease Disease Management Disease Progression Disease model Dyspnea Education Exercise Exercise Tolerance Exertion Exhibits Functional disorder General Population Goals Healed Heart failure Individual Inflammation Interleukin-6 Intervention Investigation Lung Martial Arts Measures Mediating Medical Mind-Body Intervention Moods Morbidity - disease rate Obstructive Lung Diseases Operative Surgical Procedures Outcome Outcome Measure Outpatients Oxygen Patients Physical activity Physiological Population Prevalence Primary Health Care Public Health Quality of life Questionnaires Randomized Controlled Trials Recruitment Activity Rehabilitation therapy Relaxation Reporting Research Role Self Efficacy Self Perception Serum Shortness of Breath Skeletal Muscle Smoking Social support Staging Stress Stress Tests Symptoms System Tai Ji Techniques Time Training Tumor Necrosis Factor-alpha United States Universities Walking arm body-mind center for epidemiological studies depression scale clinical efficacy design flexibility functional status group intervention healing health related quality of life heart rate variability human TNF protein improved indexing insight lung volume mortality novel novel strategies patient oriented primary outcome programs psychosocial public health relevance respiratory stress management trend uptake

项目摘要

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a major public health problem and is the fourth leading cause of death in the United States. Despite pharmacologic and surgical therapy, COPD continues to cause considerable morbidity and mortality and is the only major disease among the top ten that continues to increase in prevalence. Novel and inexpensive interventions that can improve symptoms, health-related quality-of-life, functional capacity, and potentially modify disease progression are needed. Tai chi is a popular mind-body exercise that combines gentle physical activity, self awareness, and relaxation with slow mind-body breathing. It may be particularly suited to deconditioned individuals with COPD, who suffer from limited exercise tolerance and shortness of breath on exertion, and it integrates multiple components relevant to COPD management, including low-intensity aerobic exercise, stress management and slow mind-body breathing training. In this application, we propose a 3-arm randomized controlled trial (N=102) to evaluate the benefits of tai chi exercise (which includes mind-body breathing) versus seated mind-body breathing alone (an isolated, key component of the comprehensive tai chi program) versus education control. This design will allow us to examine the individual efficacy of each mind-body intervention on clinical outcomes in COPD, but will also allow clinical and physiological comparisons between the two interventions, providing insight into the components and mechanisms of mind-body therapies. Patients with COPD (Global Obstructive Lung Disease stages 1-3 with symptoms of dyspnea) will be recruited from outpatient primary care and pulmonary clinics. Our primary aim will be to examine the effects of tai chi and mind-body breathing on quality-of-life and exercise capacity in this population. Secondary aims will further explore the effects on clinical symptoms, psychosocial indices, cardiopulmonary function, strength and flexibility, biomarkers of systemic inflammation, and autonomic activity. The results of our proposed research will help inform clinical treatment of COPD, and further our mechanistic understanding of mind-body exercises and the role of slow, mind-body breathing. PUBLIC HEALTH RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a major public health problem and is the fourth leading cause of death in the United States. This proposed study examines tai chi, a promising mind- body exercise, and one of its key components, slow mind-body breathing, that may be particularly relevant and beneficial to patients with COPD. The results of this study will help inform clinical treatment of COPD, and further our mechanistic understanding of mind-body therapies in general and the role of slow mind-body breathing.

描述（由申请人提供）：慢性阻塞性肺疾病（COPD）是一个主要的公共卫生问题，是美国第四大死因。尽管进行了药物和手术治疗，慢性阻塞性肺病仍然造成相当大的发病率和死亡率，并且是十大患病率持续上升的主要疾病。需要新颖且廉价的干预措施来改善症状、与健康相关的生活质量、功能能力，并可能改变疾病进展。太极拳是一种流行的身心运动，它将温和的身体活动、自我意识和放松与缓慢的身心呼吸结合在一起。它可能特别适合患有慢性阻塞性肺病（COPD）的人，他们的运动耐量有限，劳累时呼吸短促，并且它集成了与慢性阻塞性肺病管理相关的多个组成部分，包括低强度有氧运动、压力管理和缓慢的身心呼吸训练。在此应用中，我们提出了一项 3 组随机对照试验 (N=102)，以评估太极拳运动（包括身心呼吸）与单独坐式身心呼吸（综合运动中一个孤立的关键组成部分）的益处。太极拳计划）与教育控制。这种设计将使我们能够检查每种身心干预措施对慢性阻塞性肺病临床结果的个体疗效，同时也允许对两种干预措施进行临床和生理比较，从而深入了解身心疗法的组成部分和机制。慢性阻塞性肺病（具有呼吸困难症状的全球阻塞性肺病 1-3 期）患者将从门诊初级保健和肺部诊所招募。我们的主要目标是研究太极拳和身心呼吸对这一人群的生活质量和运动能力的影响。次要目标将进一步探讨其对临床症状、社会心理指标、心肺功能、力量和灵活性、全身炎症生物标志物和自主活动的影响。我们提出的研究结果将有助于为慢性阻塞性肺病的临床治疗提供信息，并进一步加深我们对身心锻炼以及缓慢的身心呼吸的作用的机制理解。公共卫生相关性：慢性阻塞性肺疾病 (COPD) 是一个主要的公共卫生问题，也是美国第四大死因。这项拟议的研究考察了太极拳，一种很有前途的身心运动，及其关键组成部分之一——缓慢的身心呼吸，这可能对慢性阻塞性肺病患者特别相关且有益。这项研究的结果将有助于为慢性阻塞性肺病的临床治疗提供信息，并进一步加深我们对身心疗法的一般机制以及缓慢的身心呼吸的作用的理解。