Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach

老年糖尿病前期患者维持阻力训练：理论方法

基本信息

批准号：
8531226
负责人：
BRENDA M DAVY
金额：
$ 56万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8531226
关键词：
Activities of Daily Living Adherence Adult Aerobic Affect Aging Area Behavior Therapy Behavioral Beta Cell Body Weight decreased C-Peptide Cells Clinical Trials Communities Data Diabetes Mellitus Diabetes prevention Digestive System Disorders Disease Elderly Exercise Exhibits Family Fatty acid glycerol esters Generic Drugs Glucose Glycogen (Starch) Synthase Health Health Benefit Healthy People 2010 Homeostasis Impaired fasting glycaemia Individual Informal Social Control Institutes Insulin Intervention Investments Kidney Diseases Maintenance Measures Mediating Metabolic Modality Modeling Muscle National Institute of Diabetes and Digestive and Kidney Diseases Non-Insulin-Dependent Diabetes Mellitus Oral Outcome Outcome Measure Phase Phase II Clinical Trials Physical activity Population Prediabetes syndrome Prevalence Prevention Research Prevention strategy Property Protocols documentation Public Health Randomized Reporting Research Resistance Risk SLC2A1 gene Self Efficacy Specificity Supervision Time Training Woman Work aged base blood glucose regulation density disability disorder prevention fasting glucose fitness glucose tolerance impaired glucose tolerance improved inclusion criteria indexing insulin sensitivity meetings men primary outcome programs sarcopenia skills social cognitive theory strength training theories

项目摘要

DESCRIPTION (provided by applicant): The aim of this Phase II Clinical Trial is to demonstrate the efficacy of social cognitive theory (SCT) based intervention for initiating, and most importantly, maintaining resistance training in older adults with pre-diabetes (i.e., impaired glucose tolerance or impaired fasting glucose) to improve glucose homeostatis. The overall aim is consistent with NIDDK's Behavioral/Prevetion Research Program's forcus on individual, family, and community-based strategies for prevention of diabetes and its complications. Resistance training is particularly applicable to older, prediabeteic adults given the loss of lean body mass and worsening of glucose tolerance with aging. The proposed research program evaluates a 15-month SCT based intervention for maintenance of resistance training with older adults. Men and women 50-69 (N=220) with pre-diabetes, defined as exhibiting either impaired glucose tolerance (IGT; 2-h glucose 140-199 mg/dl) or impaired fasting glucose (IFG; 100-125 mg/dl), will first follow the same standard, supervised 3-month initiation period with resistance training. All people completing the Initial Phase will be randomly assigned to 1 of 3 maintenance conditions: 1. a long-term SCT based, ASPIRE intervention, emphasizing self-regulation and other SCT strategies to optimize training, with faded contact; 2. a long-term Generic intervention lacking a number of SCT components but with the same faded contact, or, 3. a Standard intervention with more minimal contact. The primary outcome measures are indices of pre-diabetes (glucose tolerance and fasting glucose concentration) and strength. Secondary measures include adherence; ss-cell responsivity, insulin sensitivity, and disposition index, as determined by the oral glucose and C-peptide minimal model; fat free mass, other indicators of health and metabolic fitness, and SCT measures. Assessments will occur at baseline, at the end of the Initiation Phase (3 months), at the end of the different interventions (9 months) and 6 months after all contact has ended (15 months from baseline). It is hypothesized that SCT based resistance training with faded contact will produce better outcomes than Generic based training with faded contact, which in turn, will produce better outcomes than Standard-based resistance training at 9 month and 15 month assessments. It also is hypothesized that improvements in glucose homeostasis and in strength from resistance training will be mediated by adherence, self-efficacy, and use of self-regulation strategies. Resistance training has become an important component in the treatment and prevention of diseases and disabilites, and especially so for Type 2 diabetes. Critical to public health and a focus of NIDDK are theory-based interventions that enable, effective long-term resistance training with minimal supervision after an initiation phase and where improvements in adherence and outcomes are facilitated by theoretical constructs.

描述（由申请人提供）：本 II 期临床试验的目的是证明基于社会认知理论 (SCT) 的干预措施对于糖尿病前期（即糖尿病前期老年人）启动且最重要的是维持阻力训练的有效性。葡萄糖耐量或空腹血糖受损）以改善葡萄糖稳态。总体目标与 NIDDK 的行为/预防研究计划的重点是一致的，该计划的重点是个人、家庭和社区预防糖尿病及其并发症的策略。鉴于随着年龄的增长，去脂体重会减少，糖耐量会恶化，阻力训练特别适用于老年糖尿病前期患者。拟议的研究计划评估了一项为期 15 个月的基于 SCT 的干预措施，用于维持老年人的阻力训练。男性和女性 50-69 (N=220) 患有糖尿病前期，定义为表现出糖耐量受损（IGT；2 小时血糖 140-199 mg/dl）或空腹血糖受损（IFG；100-125 mg/dl）），将首先遵循相同的标准，监督3个月的阻力训练起始期。所有完成初始阶段的人员将被随机分配到 3 个维持条件中的 1 个： 1. 基于长期 SCT 的 ASPIRE 干预，强调自我调节和其他 SCT 策略来优化训练，具有褪色接触； 2. 长期通用干预，缺乏许多 SCT 组件，但具有相同的褪色接触，或者， 3. 具有更最小接触的标准干预。主要结果指标是糖尿病前期指数（葡萄糖耐量和空腹血糖浓度）和强度。次要措施包括坚持；由口服葡萄糖和 C 肽最小模型确定的 ss 细胞反应性、胰岛素敏感性和处置指数；除脂体重、其他健康和代谢健康指标以及 SCT 测量。评估将在基线、启动阶段结束时（3 个月）、不同干预措施结束时（9 个月）以及所有接触结束后 6 个月（距基线 15 个月）进行。据推测，在 9 个月和 15 个月的评估中，基于 SCT 的褪色接触阻力训练将比基于通用褪色接触的阻力训练产生更好的结果，而后者又将比基于标准的阻力训练产生更好的结果。还假设葡萄糖稳态和抗阻训练力量的改善将通过坚持、自我效能和自我调节策略的使用来介导。阻力训练已成为治疗和预防疾病和残疾的重要组成部分，尤其是 2 型糖尿病。对公共卫生至关重要，也是 NIDDK 的重点是基于理论的干预措施，这些干预措施能够在启动阶段后以最少的监督进行有效的长期阻力训练，并且通过理论构建促进坚持和结果的改善。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Questionnaires for outcome expectancy, self-regulation, and behavioral expectation for resistance training among young-old adults: development and preliminary validity.

年轻老年人阻力训练的结果预期、自我调节和行为预期问卷：发展和初步有效性。

DOI：
发表时间：
2015-04
期刊：
影响因子：
1.5
作者：
Williams, David M;Savla, Jyoti;Davy, Brenda M;Kelleher, Sarah A;Marinik, Elaina L;Winett, Richard A
通讯作者：
Winett, Richard A

Theory-based approach for maintaining resistance training in older adults with prediabetes: adherence, barriers, self-regulation strategies, treatment fidelity, costs.

用于维持老年糖尿病前期患者阻力训练的基于理论的方法：依从性、障碍、自我调节策略、治疗保真度、成本。

DOI：
发表时间：
2015-06
期刊：
影响因子：
3.6
作者：
Winett, Richard A;Davy, Brenda M;Savla, Jyoti;Marinik, Elaina L;Kelleher, Sarah A;Winett, Sheila G;Halliday, Tanya M;Williams, David M
通讯作者：
Williams, David M

Adapting the "Resist Diabetes" Resistance Training Intervention for Veterans.

为退伍军人调整“抵抗糖尿病”阻力训练干预措施。