Protein Kinases and Protein Phosphorylation

蛋白激酶和蛋白磷酸化

基本信息

批准号：
8597864
负责人：
Reuben Shaw
金额：
$ 0.4万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-10 至 2014-07-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597864
关键词：
Academia Affect Anniversary Antineoplastic Agents Area Autophagocytosis Biochemical Biological Process Cancer Biology Cell physiology Cellular biology Chairperson Clinic Clinical Clinical Trials Collaborations Communication Communication Research Data Development Diagnosis Discipline Disease Doctor of Philosophy Ensure Enzymes Event Faculty Feedback Fertilization Fostering Future Genetic Goals Growth and Development function Home environment Human Human Genome Industry Institution International Knowledge Laboratories Malignant Neoplasms Mediating Metabolism Minority Molecular Mutation New York Pathway interactions Pharmacologic Substance Phosphorylation Phosphotransferases Play Prevention Protein Kinase Protein Kinase Protein Phosphorylation Ras/Raf Recruitment Activity Regulation Reporting Research Research Personnel Resistance Role Running Scientist Signal Pathway Signal Transduction Source Staging Structure Students System Technology Therapeutic Therapeutic Intervention Time Translational Research Woman Work abstracting anticancer research base cell growth developmental disease falls human FRAP1 protein human disease improved inhibitor/antagonist insight interest kinase inhibitor lectures meetings member new technology new therapeutic target next generation novel novel strategies novel therapeutics posters professor public health relevance resistance mechanism symposium transmission process

项目摘要

DESCRIPTION (provided by applicant): The goal of the signal transduction field is to identify and characterize the biochemical and molecular basis of communication from one molecule to another as part of a signaling pathway. Over the last 30 years, this knowledge has provided a vastly improved understanding of how kinases and phosphorylation events control all known cellular processes associated with normal growth and development. Unfortunately, these pathways are also deregulated through an assortment of mechanisms, and when this occurs a variety of human developmental disorders and diseases arise. There are over 500 protein kinases in the human genome with the potential to regulate protein phosphorylation, but relatively few are well characterized. Of those that are, many are now known to possess important functions in normal development and disease. Because of the central role these enzymes play in a variety of biological processes and in many human diseases, and because protein kinases are potential targets for therapeutic intervention, a tremendous effort has been made at determining the molecular basis for information transmission and the biological processes affected. The characterization of new kinases and their functions will likely reveal even more novel therapeutic targets. The study of molecular cancer research has often been intertwined with advances in the study of kinases and phosphorylation, as it is now known that alterations in kinases are amongst the most common mutations found across nearly all known forms of human cancer. As a result, kinase inhibitors have emerged as the most prevalent form of anti-cancer agents in the past 50 years, with hundreds of new kinase inhibitors entering clinical trials every year for the past few years. These are truly exciting times in the protein kinase and protein phosphorylation arena. Thus, it is critical that the exchange of information and ideas between the leading scientists in the field occur in order for this scientific discovery o proceed. Since its inception in 1983, the FASEB summer research conference on "Protein Kinases and Protein Phosphorylation" (held biennially) has consistently been one of the preeminent meetings in the field of signal transduction, providing a premier venue for the communication of research findings from both academia and industry. The goal of the proposed conference is to continue this tradition of exciting and enthusiastic scientific exchange.

描述（由申请人提供）：信号转导领域的目标是识别和表征作为信号传导途径一部分的从一个分子到另一个分子的通信的生化和分子基础。在过去的 30 年里，这些知识极大地提高了人们对激酶和磷酸化事件如何控制与正常生长和发育相关的所有已知细胞过程的理解。不幸的是，这些途径也通过各种机制解除管制，当这种情况发生时，就会出现各种人类发育障碍和疾病。人类基因组中有超过 500 种蛋白激酶具有调节蛋白磷酸化的潜力，但得到充分表征的蛋白激酶相对较少。其中，许多现在已知在正常发育和疾病中具有重要功能。由于这些酶在多种生物过程和许多人类疾病中发挥着核心作用，并且由于蛋白激酶是治疗干预的潜在靶标，因此在确定信息传递的分子基础和受影响的生物过程方面付出了巨大的努力。。新激酶及其功能的表征可能会揭示更多新的治疗靶点。分子癌症研究通常与激酶和磷酸化研究的进展交织在一起，因为现在已知激酶的改变是几乎所有已知形式的人类癌症中最常见的突变之一。因此，激酶抑制剂已成为过去 50 年来最流行的抗癌药物，过去几年每年都有数百种新的激酶抑制剂进入临床试验。这是蛋白激酶和蛋白磷酸化领域真正激动人心的时刻。因此，为了使这一科学发现得以继续，该领域的顶尖科学家之间进行信息和思想的交流至关重要。自 1983 年成立以来，FASEB 夏季研究会议“蛋白质激酶和蛋白质磷酸化”（每两年举行一次）一直是信号转导领域的杰出会议之一，为交流双方的研究成果提供了首要场所。学术界和工业界。拟议会议的目标是延续这种令人兴奋和热情的科学交流的传统。