Animal Imaging Core

动物成像核心

• 批准号: 8540388
• 负责人: Weili Lin
• 金额: $ 6.65万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540388
• 关键词: Animal Technicians; Animals; Biodistribution; Biological; Biomedical Research; Blood Vessels; Brain Neoplasms; Cancer Center; Commit; Cyclotrons; Development; Disease Progression; Equipment; Faculty; Funding; Goals; Housing; Image; Image Analysis; Imaging Techniques; Imaging technology; Institution; Lead; Magnetic Resonance Imaging; Measures; Methods; Monitor; Nanotechnology; Non-Small-Cell Lung Carcinoma; Optics; Positron-Emission Tomography; Preparation; Protocols documentation; Radiochemistry; Recruitment Activity; Research Infrastructure; Research Personnel; Resources; Secure; Site; Technical Expertise; Treatment Efficacy; Treatment Protocols; Tumor Volume; Ultrasonography; Vascular Permeabilities; base; biological systems; density; image registration; imaging modality; improved; in vivo; indexing; insight; member; multimodality; nanoparticle; novel; operation; optical imaging; programs; single photon emission computed tomography; success; tool; treatment response

Title: Animal Imaging Core Recent advances in small animal imaging have substantially improved our ability to gain insights into disease progression without altering the biological systems. The small animal imaging facility at UNC currently houses nine major imaging equipments, including MRI (2), PET/CT (1), CT (1), SPECT (1), optical imaging (3), and ultrasound (1). In addition, skillful technical staff members to maintain and operate the imaging equipments and animal technicians to facilitate animal preparation for imaging and monitoring during imaging are available. Leveraging on these impressive resources, the small animal imaging (SAI) core aims to provide advanced imaging technology to facilitate the proposed projects. Specifically, two major imaging tasks will be carried out for the proposed projects, including to depict biodistribution of nanoparticles (Projects 1, 2, and 3) and to monitor and evaluate therapeutic efficacy of the proposed nanoparticles or treatment regimens (Projects 2, 3, and 4) using imaging methods. To accomplish the former task, both PET and optical imaging methods will be developed to more efficiently and accurately provide biodistribution information. For the latter task, four imaging modalities, including optical, CT, PET, and MRI will be used to monitor therapeutic efficacy. Finally, while the imaging capability in the small animal imaging facility is already impressive, our institution has committed additional funds to further augment the imaging program at UNC, including the establishment of an on-site cyclotron facility and the associated radiochemistry lab and the development of imaging registration approaches for multimodality imaging using microCT, MRI, and PET (Projects 2, 3 and 4). Together, we believe that the available technical expertise and well established infrastructure in the small animal imaging facility will greatly facilitate the success ofthe proposed projects.

标题：动物成像核心 小动物成像的最新进展大大提高了我们在不改变生物系统的情况下洞悉疾病进展的能力。 UNC的小型动物成像设施目前包含9个主要成像设备，包括MRI（2），PET/CT（1），CT（1），SPECT（1），光学成像（3）和超声（1）。此外，还可以提供熟练的技术人员来维护和操作成像设备和动物技术人员，以促进动物准备在成像过程中进行成像和监测。利用这些令人印象深刻的资源，小型动物成像（SAI）核心旨在提供先进的成像技术以促进拟议的项目。具体而言，将针对拟议项目执行两项主要的成像任务，包括描述纳米颗粒的生物分布（项目1、2和3），并使用成像方法监测和评估所提出的纳米颗粒或治疗方案的治疗功效（项目2、3和4）。为了完成以前的任务，将开发PET和光学成像方法，以更有效，准确地提供生物分布信息。对于后一项任务，将使用四种成像方式，包括光学，CT，PET和MRI来监测治疗功效。最后，虽然小动物成像设施中的成像能力已经令人印象深刻，但我们的机构已投入更多资金来进一步增强UNC的成像程序，包括建立现场回旋设施和相关的放射化学实验室以及使用Microct，MRI，MRI和PETPET（Projects 2，3和4）的多模态成像的成像注册方法的开发。我们认为，在小型动物成像设施中可用的技术专长和良好的基础设施将极大地促进拟议项目的成功。