Neuroimaging Analysis Center (NAC)

神经影像分析中心 (NAC)

基本信息

批准号：
8890837
负责人：
Ron Kikinis
金额：
$ 220.4万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8890837
关键词：
Acquired Immunodeficiency Syndrome Advanced Development Age Algorithm Design Algorithms Alzheimer&apos s Disease Anatomy Appearance Architecture Atlases Autistic Disorder Automobile Driving Biomedical Research Biomedical Technology Boston Brain Brain Diseases Brain Neoplasms Collaborations Communities Computer software Computers Computing Methodologies Data Data Set Development Disease Disease model Engineering Ensure Environment Excision Functional Magnetic Resonance Imaging Funding Gap Junctions Grant Health Health Insurance Portability and Accountability Act Human Huntington Disease Image Image Analysis Imaging Techniques Individual Institution Institutional Review Boards Investigation Knowledge Life Magnetic Resonance Imaging Medical Imaging Memory Methamphetamine dependence Methodology Methods Mission Modeling Monitor Multimodal Imaging Neurodegenerative Disorders Neurologic Neurosciences Normalcy Online Systems Operative Surgical Procedures Pathology Patient Care Patients Phase Process Radiation therapy Research Research Infrastructure Research Personnel Resource Sharing Resources Role Schizophrenia Science Scientist Services Shapes Slice Software Engineering Software Tools Speed Statistical Methods Structure Surgeon Technical Expertise Technology Time Time Series Analysis Tissue Model Training Training Support Translations Traumatic Brain Injury United States National Institutes of Health Universities Work base chemotherapy chronic traumatic encephalopathy clinical application clinical decision-making cloud based comparison group computerized tools experience firewall image guided therapy image visualization improved infrastructure development innovation insight neuroimaging operation outreach programs research and development response statistics tool tumor white matter

项目摘要

The Neuroimage Analysis Center (NAC) is a National Resource Center in the Biomedical Technology Resource Center (BTRC) program that is developing image analysis algorithms and software tools to improve understanding of brain diseases and to enable innovative treatments. This competitive renewal application focuses on subject-specific analyses of medical imaging data. Underlying NAC's approach is a set of technical expertise and methodologies - Image analysis, applied statistics, tensor processing, time series analysis, and software engineering - that will enable the Center to exploit the atlas-based technologies developed in previous funding cycles to improve the analysis of individual patient data. The proposed work will be performed in four Technical Research and Development (TRD) projects and one Infrastructure project; it will be leveraged by outreach and operations activities, which include training in the use of 3D Slicer, the software platform supported by the Center. The four TRDs encompass microstructure imaging, spatio-temporal disease modeling, anatomical variability modeling, and Slicer engineering. The NAC team of investigators is augmented by subcontractors at GE, UMass Worcester, and Boston University, each of whom will provide unique expertise toward methodological and infrastructure development. The Driving Biomedical Projects (DBPs) will ensure that all Center activities continue to be highly relevant to NIH grantees. These DBPs include research in chronic traumatic encephalopathy, methamphetamine addiction and AIDS, schizophrenia, Alzheimer's disease, Huntington disease, autism, and image guided therapy. The translation of technological research into 3D Slicer as a platform for outreach represents a key deliverable In NAC's role as a resource center. The Center will continue to offer support and training at local and national venues as part of its outreach activities. Close collaboration with clinicians and scientists continues to be critical to the implementation of image analysis tools for the purpose of understanding the brain and treating Its disorders, an Important mission of the NIH.

神经图像分析中心（NAC）是生物医学技术资源中心（BTRC）计划的国家资源中心，该计划正在开发图像分析算法和软件工具，以提高对脑疾病的了解并启用创新治疗。这种竞争性更新应用的重点是对医学成像数据的特定主题分析。 NAC的基本方法是一组技术专业知识和方法 - 图像分析，应用统计，张量处理，时间序列分析和软件工程 - 将使中心能够利用以前的资金周期中开发的基于ATLAS的技术来改善分析的分析个别患者数据。拟议的工作将在四个技术研发（TRD）项目和一个基础设施项目中进行；外展和运营活动将利用它，其中包括在中心支持的软件平台3D Slicer的使用中进行培训。这四个TRD涵盖了微观结构成像，时空疾病建模，解剖变异性建模和切片机工程。 NAC的调查人员团队由GE，UMass Worcester和Boston University的分包商增加，他们每个人都将为方法论和基础设施开发提供独特的专业知识。驾驶生物医学项目（DBP）将确保所有中心活动继续与NIH受赠人高度相关。这些DBP包括研究慢性创伤性脑病，甲基苯丙胺成瘾和艾滋病，精神分裂症，阿尔茨海默氏病，亨廷顿疾病，自闭症和图像指导疗法的研究。将技术研究转化为3D Slicer作为外展平台代表了NAC作为资源中心角色的关键。作为其外展活动的一部分，该中心将继续在当地和国家场所提供支持和培训。与临床医生和科学家的密切合作对实施图像分析工具的实施至关重要，以理解大脑和治疗其疾病，这是NIH的重要任务。