Alerations of Sleep and Circadian Timing in Aging

衰老过程中睡眠和昼夜节律的变化

基本信息

批准号：
8448179
负责人：
Eve Van Cauter
金额：
$ 179.41万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-02-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8448179
关键词：
Address Adult Adverse effects Affect Age Aging Aging-Related Process American Animal Model Animals Area Bass Behavioral Beta Cell Biological Biological Assay Biological Preservation Blood Body Weight Brain Calories Cardiovascular Diseases Chronic Circadian Dysregulation Circadian Rhythms Clinical Research Cognition Coin Data Data Collection Data Set Development Diabetes Mellitus Diet Disease Educational workshop Elderly Energy Metabolism Environment Epidemic Epidemiologic Studies Ethnic Origin Explosion Fatty acid glycerol esters Financial compensation Food Foundations Functional disorder Funding Genes Genetic Goals Gold Grant Health Heritability High Prevalence Hormones Hour Human Hunger Impact evaluation Impairment Individual Individual Differences Intake Intervention Label Laboratory Study Lead Learning Leptin Link Logistics Measures Mediating Mental Depression Metabolic Metabolic Pathway Metabolic syndrome Metabolism Methods Molecular Molecular Genetics Molecular Models Mus Mutation Nature Neurocognitive Deficit Neurosecretory Systems Non-Insulin-Dependent Diabetes Mellitus Nutrient Obesity Obstructive Sleep Apnea Organ Overweight Peripheral Phase Phenotype Physical activity Physiological Play Predisposition Procedures Quality of life Race Rattus Recovery Recurrence Regulation Reporting Request for Applications Research Research Personnel Resources Rest Risk Risk Factors Rodent Rodent Model Role Satiation Severities Side Sleep Sleep Apnea Syndromes Sleep Deprivation Sleep Disorders Sleep Fragmentations Sleep Wake Cycle Sleep disturbances Sleeplessness Slow-Wave Sleep Social Work Socioeconomic Status Stress Sum System Testing Ticks Time Translational Research United States National Center for Health Statistics United States National Institutes of Health Wakefulness Water Weight Weight Gain Work Writing age related allostasis allostatic load base biological adaptation to stress circadian pacemaker cytokine db/db mouse fly gene discovery genetic analysis genetic pedigree ghrelin high risk impaired glucose tolerance in vivo insulin sensitivity interest leptin receptor molecular modeling mouse model mutant normal aging novel obesity risk programs response restoration sedentary sleep regulation tool trait treatment duration

项目摘要

DESCRIPTION (provided by applicant): Our group has identified reduced sleep duration as a novel risk factor for obesity and type 2 diabetes. During the previous grant period, we have shown that reduced sleep quality, specifically reduced deep slow-wave sleep (SWS), has adverse cardiometabolic consequences and obtained evidence that a "vicious cycle" may interconnect sleep and circadian disruption with cardiometabolic disease. In both humans and rodents, we further observed that chronic partial sleep restriction alters the homeostatic regulation of sleep, a phenomenon that may be referred to as an "allostasis" of sleep regulation. Normal aging is associated with reductions in sleep duration, sleep quality and circadian function. The present Program Project focuses on the interactions between chronic reductions of sleep duration, sleep quality and circadian function and the age-related increase in cardiometabolic disease. A multi-disciplinary approach combining statistical analyses of a large data set, clinical research (in healthy adults of all ages, older insomniacs, and older adults with sleep disturbances), in vivo studies in a rodent model of chronic partial sleep loss and molecular and genetic analyses will be used to: 1. test the hypothesis that individuals with low SWS because of age, ethnicity or genetic factors, are at higher risk for type 2 diabetes (human studies, E. Van Cauter, PI); 2. test the hypothesis that the preservation or restoration of SWS has beneficial cardiometabolic effects (human studies, E. Tasali, PI); 3. test the hypothesis that the most common types of insomnia in older adults are associated with reduced SWS and cardiometabolic alterations (human studies; P.C. Zee, PI); 4. perform a comprehensive evaluation of the impact of age on sleep allostasis during chronic partial sleep restriction and determine the cardiometabolic consequences (rat studies; F.W. Turek, PI); 5. dissect the molecular basis for accelerated metabolic aging induced by circadian disruption and sleep loss (mouse studies; J. Bass, PI). Core A (Administrative) will provide logistic and financial coordination. Core B (Methods and Analysis) will standard operating procedures for data collection, archival and analysis. Core C will assay peripheral levels of hormones, cytokines and other blood constituents.

描述（由申请人提供）：我们的小组已经确定睡眠持续时间减少是肥胖和2型糖尿病的新风险因素。在上一个赠款期间，我们表明睡眠质量降低，特别减少了深层慢波睡眠（SWS），具有不利的心脏代谢后果，并获得了证据表明，“恶性循环”可能会与心脏代谢性疾病相互连接，而昼夜节律破坏。在人类和啮齿动物中，我们进一步观察到，慢性部分睡眠限制会改变睡眠的体内调节，这一现象可能被称为睡眠调节的“ Allostasis”。正常衰老与睡眠持续时间减少，睡眠质量和昼夜节律功能有关。本计划项目的重点是睡眠持续时间，睡眠质量和昼夜节律功能与心脏代谢疾病与年龄有关的增加之间的相互作用。一种多学科方法，结合了大型数据集，临床研究（在所有年龄段的健康成年人中，较旧的失眠症和患有睡眠障碍的老年人），体内研究中，在慢性部分睡眠损失和分子和遗传分析的啮齿动物模型中，在较高的风险或遗传上，由于：1。糖尿病（人类研究，E。VanCauter，PI）； 2。检验以下假设：SWS的保存或恢复具有有益的心脏代谢作用（人类研究，E。Tasali，PI）； 3。检验以下假设：老年人中最常见的失眠类型与SWS减少和心脏代谢改变有关（人类研究； P.C. Zee，PI）； 4.对年龄对慢性部分睡眠限制期间睡眠同层的影响进行全面评估，并确定心脏代谢后果（大鼠研究； F.W. Turek，PI）； 5。解剖昼夜节律破坏和睡眠损失引起的加速代谢老化的分子基础（小鼠研究； J. Bass，PI）。核心A（行政）将提供后勤和财务协调。核心B（方法和分析）将标准用于数据收集，档案和分析的操作程序。核心C将测定激素，细胞因子和其他血液成分的外围水平。