WUMC Cancer and Leukemia Group B

WUMC 癌症和白血病 B 组

基本信息

批准号：
8455697
负责人：
NANCY L BARTLETT
金额：
$ 32.01万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-08 至 2014-02-28
项目状态：
已结题

项目摘要

Washington University has been a CALGB main member institution since 1986. Over the last six years, the Siteman Cancer Center (SCC) at Barnes-Jewish Hospital and Washington University School of Medicine (WUMS) has grown to become one of the leading NCI Cancer Centers nationally. Designated in 2004 as a Comprehensive Cancer Center and in 2006 as the 20th member of the National Comprehensive Cancer Network (NCCN), Siteman has enhanced its collaborative and translational infrastructure, which has increased the scientific capacity of the CALGB at Washington University. During the last grant cycle, 3 Washington University faculty members chaired CALGB scientific committees, and 11 additional faculty members served on scientific committees. From 2003-2008, WUMS faculty chaired 26 treatment and correlative science protocols and co-authored 74 CALGB publications. WUMS has continued to accrue well throughout the entire grant period, ranking in the top 5 among CALGB institutions every year. WUMS accrual to all CALGB trials during this grant period averaged 293/year with an average of 140 patients/year accrued to therapeutic trials. Our portfolio remains diverse with excellent accruals to breast, Gl, GU, leukemia and lymphoma studies. Several newfaculty recruits in 2007-2008 will further enhance our ability to contribute to the CALGB scientific mission, specifically in the areas of breast cancer, pharmacology and experimental therapeutics, thoracic oncology, leukemia, and lymphoma. Collaborations are ongoing between WUMS investigators and the CALGB leukemia tissue bank, with continued efforts to identify key mutations in AML. Goals for the next grant cycle include 1) continued efforts to increase accruals, particularly minority accruals to CALGB trials, 2) increased involvement of WUMS investigators in CALGB scientific committees specifically leukemia, PET, Gl, and imaging 3) increased involvement of our very experienced and outstanding CRAs in the audit and CRA committees, and 4) improved communication between WUMS and CALGB regarding resources available at the SCC that will enhance the scientific mission of CALGB, specifically our ability to perform high quality correlative studies.

华盛顿大学自 1986 年以来一直是 CALGB 主要成员机构。在过去六年中，巴恩斯犹太医院的斯特曼癌症中心 (SCC) 和华盛顿大学医学院 (WUMS) 已发展成为领先的 NCI 癌症中心之一全国范围内。 Siteman 于 2004 年被指定为综合癌症中心，并于 2006 年成为国家综合癌症网络 (NCCN) 第 20 个成员，加强了其协作和转化基础设施，从而提高了华盛顿大学 CALGB 的科学能力。在上一个资助周期中，3 名华盛顿大学教职人员担任 CALGB 科学委员会主席，另有 11 名教职人员在科学委员会任职。从 2003 年到 2008 年，WUMS 教师主持了 26 项治疗和相关科学方案，并与人合着了 74 篇 CALGB 出版物。 WUMS 在整个资助期内持续积累良好的收益，每年在 CALGB 机构中排名前 5。世界气象组织在此资助期内，所有 CALGB 试验的平均每年有 293 名患者参加治疗试验，其中平均每年有 140 名患者参加治疗试验。我们的产品组合保持多元化，在乳腺癌、胃肠道、泌尿道、白血病和淋巴瘤研究方面取得了良好的成果。 2007-2008 年新招募的几名教师将进一步增强我们为 CALGB 科学使命做出贡献的能力，特别是在乳腺癌、药理学和实验治疗学、胸部肿瘤学、白血病和淋巴瘤领域。 WUMS 研究人员和 CALGB 白血病组织库之间正在进行合作，继续努力识别 AML 的关键突变。下一个拨款周期的目标包括 1) 继续努力增加应计项目，特别是 CALGB 试验的少数应计项目，2) 增加 WUMS 研究人员在 CALGB 科学委员会中的参与，特别是白血病、PET、GL 和成像 3) 增加我们经验丰富的人员的参与以及审计和 CRA 委员会中杰出的 CRA，以及 4) 改善了 WUMS 和 CALGB 之间有关 SCC 可用资源的沟通，这将增强 CALGB 的科学使命，特别是我们的科学使命进行高质量相关研究的能力。