Administrative Core

行政核心

• 批准号: 8741241
• 负责人: ELI J. GLATSTEIN
• 金额: $ 9.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-07 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8741241
• 关键词: Biological; Clinical; Clinical Trials; Collaborations; Communication; Consult; Data; Ensure; Excision; Goals; Grant; Human Resources; Manuscripts; Monitor; Nature; Operative Surgical Procedures; Patients; Pennsylvania; Photochemotherapy; Pleural; Procedures; Publications; Regulation; Research; Resources; Roswell Park Cancer Institute; Schools; Services; Site; Tissues; Translations; Treatment Efficacy; Universities; Update; abstracting; base; bench to bedside; clinically relevant; data sharing; design; improved; meetings; novel; programs; repository; success

Abstract Core D: This Program Project (PPG) comprises a highly integrated effort between a number of programs, departments and schools within the University of Pennsylvania (PENN) and Roswell Park Cancer Institute (RPCI). The complimentary and interwoven nature of the aims for the projects and cores supports and encourages extensive sharing of data, tissues and core services. This synergistic design allows concurrent, bidirectional bedside-bench translation, where causal/mechanistic relationships can be established for new clinical trial observations and novel mechanisms can be evaluated for clinical relevance on an ongoing, rapidly updating basis. The main purpose of the Administrative Core is to provide an organizational framework that facilitates and oversees these collaborations, while avoiding dysfunctional micromanagement to keep the effort as a whole centered on the two major themes for this grant: 1) understanding the mechanisms and clinical contribution of pleural photodynamic therapy (pPDT) in patients undergoing radical pleurectomy (RP) and 2) obtaining improved mechanistic understanding of the impact of surgical resection on pPDT efficacy. The specific aims for the Administrative Core are as follows: Aim 1) Coordinate and supervise research efforts; Aim 2) Enhance communication and collaboration; Aim 3) Provide administrative and regulatory support.

抽象核心D： 该计划项目（PPG）由多个计划、部门之间的高度集成的努力组成 以及宾夕法尼亚大学 (PENN) 和罗斯威尔帕克癌症研究所 (RPCI) 内的学校。这 项目和核心目标的互补性和相互交织性支持和鼓励 数据、组织和核心服务的广泛共享。这种协同设计允许并发、双向 床边-工作台翻译，可以为新的临床试验建立因果/机械关系 可以评估观察结果和新机制的临床相关性，持续快速更新 基础。行政核心的主要目的是提供一个组织框架，以促进 并监督这些合作，同时避免失灵的微观管理，以保持努力作为 整个研究围绕本次资助的两大主题：1）了解机制和临床 胸膜光动力疗法 (pPDT) 对接受根治性胸膜切除术 (RP) 的患者的贡献和 2) 更好地了解手术切除对 pPDT 疗效影响的机制。这 行政核心的具体目标如下： 目标 1) 协调和监督研究工作；目的 2）加强沟通与协作；目标 3) 提供行政和监管支持。