Genetic Contributions of Negative Valence Systems to Internalizing Pathways

负价系统对内化途径的遗传贡献

• 批准号: 8573698
• 负责人: Roxann Roberson-Nay
• 金额: $ 59.23万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-16 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8573698
• 关键词: Accounting; Adolescence; Adolescent; Affect; Affective; Anhedonia; Anxiety; Architecture; Autonomic nervous system; Behavioral inhibition; Breathing; Carbon Dioxide; Caucasians; Caucasoid Race; Childhood; Clinical; Data; Depressed mood; Development; Dimensions; Disease; Distress; Emotional; Emotional Disturbance; Emotions; Environment; Environmental Risk Factor; Event; Exhibits; Face; Family; Fright; General Population; Genes; Genetic; Goals; Health; Heritability; High Prevalence; Home environment; Hydrocortisone; Individual; Internet; Knowledge; Life; Mails; Measures; Neurotic Disorders; Outcome; Panic; Pathway interactions; Patient Self-Report; Pattern; Persons; Pharmaceutical Preparations; Phenotype; Physiological; Play; Prevention; Process; Psychopathology; Public Health; Registries; Risk Factors; Role; Salivary; Sampling; Series; Specificity; Staging; Stress; Structure; Symptoms; Syndrome; System; Teenagers; Trier Social Stress Test; Twin Multiple Birth; aged; alpha-amylase; base; critical developmental period; design; disease classification; endophenotype; environmental change; follow-up; peer; relating to nervous system; response; sex; young adult

DESCRIPTION (provided by applicant): Internalizing disorders (ID) represent the largest domain of emotional disturbances that affect the general population. In recent years, significant effort has been put into examining and defining basic dimensions of functioning (e.g., neural or physiologic) that cut across internalizing disorders as traditionally defined by current nosology. Thus, the goal of the current study is to examine relationships between measures constructed to probe negative valence system (NVS) expression (e.g., fear, anhedonia) in a genetically informative adolescent twin sample. This design allows for the examination of the interplay between genetic and environmental factors as a way of elucidating causal mechanisms involved in the NVS and the role the NVS plays in pathways to internalizing symptoms and syndromes. Within this design we will administer an informative suite of well-validated dimensional measures that tap into the NVS, focusing on five related constructs including anxiety, fear, stress, sadness/anhedonia, and irritability. The influence of genes on psychopathology changes such that different developmental stages are associated with a unique pattern of risk factors representing a dynamic interplay between development, genes, and environment. For this reason, we will target a critical developmental period, focusing on the transition that begins during the late teen years and proceeds into young adulthood. This transition will involve moving away from home/family and established peer networks for approximately half of the general population. For these individuals, a number of significant environmental changes will occur that will impact their emotional functioning and trajectory of internalizing symptom expression. Thus, measuring NVS before this unique developmental period from a genetically informed perspective is ideal for determining the shared and specific contributions of genes and environment to NVS expression and its influence on ID development.

描述（由申请人提供）：内化障碍（ID）代表了影响普通人群的最大情绪障碍领域。近年来，人们投入了大量精力来检查和定义功能的基本维度（例如神经或生理），这些维度跨越了当前疾病分类学传统定义的内化障碍。因此，本研究的目标是检查在遗传信息丰富的青少年双胞胎样本中为探测负价系统（NVS）表达（例如恐惧、快感缺乏）而构建的测量之间的关系。这种设计允许检查遗传和环境因素之间的相互作用，作为阐明 NVS 涉及的因果机制以及 NVS 在内化症状和综合征途径中所发挥的作用的一种方式。在这个设计中，我们将管理一套信息丰富、经过充分验证的维度测量，这些测量利用 NVS，重点关注五个相关的概念，包括焦虑、恐惧、压力、悲伤/快感缺乏和易怒。基因对精神病理学的影响发生变化，不同的发育阶段与代表发育、基因和环境之间动态相互作用的独特风险因素模式相关。因此，我们将瞄准一个关键的发展时期，重点关注从青少年晚期开始一直到成年早期的过渡。这一转变将涉及离开家庭/家人并为大约一半的总人口建立同侪网络。对于这些人来说，将会发生许多重大的环境变化，这将影响他们的情绪功能和内化症状表达的轨迹。因此，在这个独特的发育时期之前从遗传角度测量 NVS 对于确定基因和环境对 NVS 表达的共同和特定贡献及其对 ID 发育的影响是理想的。