Influence of physical activity and weight loss on brain plasticity

体力活动和减肥对大脑可塑性的影响

基本信息

  • 批准号:
    8399894
  • 负责人:
  • 金额:
    $ 42.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-15 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This application proposes to add a neuroimaging arm to an NIH funded 12-month diet and physical activity intervention. Obesity is currently at epidemic proportions in the United States, affecting over 1/3rd of American adults. Impaired cognitive and brain function - manifested as mood disorders, impulsivity, and an increased risk for neurological pathology - are often unrecognized consequences of obesity. These consequences are especially unsettling in view of the increased prevalence of obesity during childhood and adolescence, when the education, intellectual growth, and the preparation for future career seeking are at its peak. Hence, it is a public health imperative to rigorously investigate the effects of obesity on neurocognitive functions and to explore the potential for weight loss to restore cognitive and brain function. The parent study has three groups: diet only (DIET), diet + moderate physical activity (MOD-PA), diet + high physical activity (HIGH-PA) and will be collecting a myriad of outcome measures including aortic pulse wave velocity, inflammatory markers, glucose and insulin, abdominal adiposity and body composition using dual-energy X-ray absorptiometry, cardiorespiratory fitness using a graded exercise test, accelerometry measured physical activity, and energy intake. In addition to the subjects collected in the parent study we will collect a group of no-contact control (CON) participants for both reliability and comparison purposes. Therefore, by adding brain imaging to this intervention, our proposal reflects a cost effective and innovative approach to investigate links between physical activity, weight loss, brain integrity, metabolic outcomes, and cognitive processing and offers an opportunity to collect data on brain health with minimal additional costs. Testing these links could transform the way that brain-body associations are considered when assessing the risk for brain dysfunction or treating obesity related behavioral problems. Our main aims include: Aim 1. To examine whether a 12-month physical activity and weight loss intervention on overweight and obese adults increases cortical volume and improves microstructural white matter integrity, Aim 2: Examine how increased physical activity and weight loss can change the functional dynamics of the brain as assessed by both task-related neural responses, cerebral blood flow, and resting state brain connectivity, Aim 3. Link the changes in brain integrity, function, and connectivity with intervention-induced changes in physiological measures of metabolic and inflammatory molecular pathways. Our project represents the first attempt to associate weight loss in a long-term intervention to changes in brain networks. It is highly innovative, cost-effective, and will add significantly to the scientifc literature. By leveraging an existing NIH funded program and by focusing on neuroimaging outcomes with a skilled and productive team of experts in both weight loss interventions and cutting-edge neuroimaging techniques, we will be able to address unanswered questions that have important theoretical and translational implications for obesity and brain health. PUBLIC HEALTH RELEVANCE: In this study, we are examining the capacity for a 12-month physical activity and weight loss intervention to enhance brain integrity in a sample of overweight and obese adults. Our project represents the first attempt to link weight loss in a long-term intervention to changes in brain networks.
描述(由申请人提供):本申请提议在 NIH 资助的 12 个月饮食和身体活动干预措施中添加神经影像学分支。目前,肥胖在美国已成为一种流行病,影响了超过 1/3 的美国成年人。认知和大脑功能受损——表现为情绪障碍、冲动和神经病理学风险增加——往往是肥胖带来的不为人知的后果。鉴于儿童和青少年时期肥胖患病率的增加,这些后果尤其令人不安,因为此时教育、智力发展和为未来职业生涯的准备都处于高峰期。因此,严格研究肥胖对神经认知功能的影响并探索减肥恢复认知和大脑功能的潜力是公共卫生的当务之急。母研究分为三组:仅饮食(DIET)、饮食+适度体力活动(MOD-PA)、饮食+高体力活动(HIGH-PA),并将收集大量结果指标,包括主动脉脉搏波速度、炎症使用双能 X 射线吸收测量法测量标记物、葡萄糖和胰岛素、腹部肥胖和身体成分、使用分级运动测试测量心肺健康、通过加速度测量测量体力活动和能量摄入。除了在家长研究中收集的受试者外,我们还将收集一组非接触对照 (CON) 参与者,以提高可靠性和比较目的。因此,通过在这种干预措施中添加脑成像,我们的建议反映了一种具有成本效益和创新的方法来研究体育活动、减肥、大脑完整性、代谢结果和认知处理之间的联系,并提供了一个以最小的成本收集大脑健康数据的机会。额外费用。测试这些联系可以改变在评估大脑功能障碍风险或治疗肥胖相关行为问题时考虑大脑与身体关联的方式。我们的主要目标包括:目标 1. 检验对超重和肥胖成年人进行 12 个月的体力活动和减肥干预是否会增加皮质体积并改善微结构白质完整性,目标 2:检验增加体力活动和减肥如何改变通过任务相关的神经反应、脑血流量和静息状态大脑连接来评估大脑的功能动态,目标 3。将大脑完整性、功能和连接的变化与干预引起的代谢和生理测量的变化联系起来。发炎的分子途径。我们的项目是首次尝试将长期干预中的减肥与大脑网络的变化联系起来。它具有高度创新性、成本效益,并将极大地丰富科学文献。通过利用现有的 NIH 资助项目,并通过在减肥干预和尖端神经影像技术方面拥有熟练且富有成效的专家团队专注于神经影像结果,我们将能够解决对肥胖具有重要理论和转化意义的悬而未决的问题和大脑健康。 公共健康相关性:在这项研究中,我们正在研究为期 12 个月的体力活动和减肥干预措施对超重和肥胖成年人样本增强大脑完整性的能力。我们的项目是首次尝试将长期干预中的减肥与大脑网络的变化联系起来。

项目成果

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Kirk I Erickson其他文献

Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators
运动对社区老年人心理健康的剂量反应效应:遗传调节因子的探索
The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial
基线睡眠对认知未受损老年人运动引起的认知变化的影响:一项随机临床试验
  • DOI:
    10.1002/gps.6016
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Kelsey R. Sewell;S. Rainey;J. Peiffer;H. Sohrabi;J. Doecke;N. Frost;S. Markovic;Kirk I Erickson;B. Brown
  • 通讯作者:
    B. Brown
A systematic review of physical activity and quality of life and well-being.
对身体活动、生活质量和福祉的系统回顾。
  • DOI:
    10.1093/tbm/ibz198
  • 发表时间:
    2020-10-01
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    David X Marquez;Susan Aguiñaga;Priscilla M Vásquez;David E Conroy;Kirk I Erickson;Charles Hillman;Chelsea M Stillman;Rachel M Ballard;Bonny Bloodgood Sheppard;S. Petruzzello;Abby C King;Kenneth E Powell
  • 通讯作者:
    Kenneth E Powell
Emerging methods for measuring physical activity using accelerometry in children and adolescents with neuromotor disorders: a narrative review
使用加速度测量法测量患有神经运动障碍的儿童和青少年身体活动的新兴方法:叙述性回顾
  • DOI:
    10.1186/s12984-024-01327-8
  • 发表时间:
    2024-02-29
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Bailey A Petersen;Kirk I Erickson;Brad G Kurowski;M. L. Boninger;A. Treble
  • 通讯作者:
    A. Treble
Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial
检查有氧舞蹈干预对大脑健康的功效以及 ABCA7 在老年非裔美国人中的调节作用:随机对照试验方案
  • DOI:
    10.3389/fnagi.2023.1266423
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Mark A. Gluck;Joshua L. Gills;B. Fausto;Steven K. Malin;Paul R. Duberstein;Kirk I Erickson;Liangyuan Hu
  • 通讯作者:
    Liangyuan Hu

Kirk I Erickson的其他文献

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{{ truncateString('Kirk I Erickson', 18)}}的其他基金

Examining the Persistence of Neurocognitive Benefits of Exercise
检查运动对神经认知的益处的持久性
  • 批准号:
    10719280
  • 财政年份:
    2023
  • 资助金额:
    $ 42.76万
  • 项目类别:
Physical Activity and Dementia: Mechanisms of Action
体力活动和痴呆:作用机制
  • 批准号:
    10709288
  • 财政年份:
    2021
  • 资助金额:
    $ 42.76万
  • 项目类别:
Physical Activity and Dementia: Mechanisms of Action
体力活动和痴呆:作用机制
  • 批准号:
    10625333
  • 财政年份:
    2021
  • 资助金额:
    $ 42.76万
  • 项目类别:
Physical Activity and Dementia: Mechanisms of Action
体力活动和痴呆:作用机制
  • 批准号:
    10208017
  • 财政年份:
    2021
  • 资助金额:
    $ 42.76万
  • 项目类别:
Physical Activity and Dementia: Mechanisms of Action
体力活动和痴呆:作用机制
  • 批准号:
    10402850
  • 财政年份:
    2021
  • 资助金额:
    $ 42.76万
  • 项目类别:
Examining Cerebral Blood Flow as a Mechanism for the Effects of African Dance on Executive Function
检查脑血流作为非洲舞蹈对执行功能影响的机制
  • 批准号:
    10206912
  • 财政年份:
    2018
  • 资助金额:
    $ 42.76万
  • 项目类别:
Rhythm Experience and Africana Culture Trial (REACT)
节奏体验和非洲文化试验(REACT)
  • 批准号:
    10406292
  • 财政年份:
    2018
  • 资助金额:
    $ 42.76万
  • 项目类别:
Rhythm Experience and Africana Culture Trial (REACT)
节奏体验和非洲文化试验(REACT)
  • 批准号:
    10170200
  • 财政年份:
    2018
  • 资助金额:
    $ 42.76万
  • 项目类别:
Rhythm Experience and Africana Culture Trial (REACT)
节奏体验和非洲文化试验(REACT)
  • 批准号:
    9770760
  • 财政年份:
    2018
  • 资助金额:
    $ 42.76万
  • 项目类别:
Influence of physical activity and weight loss on brain plasticity
体力活动和减肥对大脑可塑性的影响
  • 批准号:
    8510639
  • 财政年份:
    2012
  • 资助金额:
    $ 42.76万
  • 项目类别:

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