Neurobehavioral assessments of RDoC domains to detect preschool mood disorders

RDoC 域的神经行为评估以检测学前情绪障碍

基本信息

批准号：
8769323
负责人：
Kate Dimond Fitzgerald
金额：
$ 8.34万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8769323
关键词：
6 year old Acute Address Adolescence Adult Affect Age Anxiety Basic Science Behavior Behavior assessment Behavioral Biological Markers Child Child Behavior Childhood Chronic Clinic Clinical Coin Comorbidity Complex Data Development Diagnosis Diagnostic Dimensions Disease Early Intervention Early identification Ensure Failure Family Feedback Foundations Fright Funding Future Genes Health Health system High Prevalence Impairment Infant Intervention Interview Investigation Life Light Link Longevity Maps Measures Mental Depression Mental Health Mental disorders Michigan Mood Disorders Morbidity - disease rate Morphologic artifacts National Institute of Mental Health Neurobiology Nursery Schools Onset of illness Parents Participant Pathway interactions Patients Pattern Pediatrics Phenotype Pilot Projects Population Preschool Child Prevalence Procedures Process Psychiatry Psychopathology Public Health Recruitment Activity Recurrence Relative (related person)Reporting Research Research Domain Criteria Research Personnel Rewards Risk Sampling Severities Symptoms Syndrome Testing Uncertainty United States National Institutes of Health Universities Work aged base child depression childhood anxiety childhood onset depression clinical infrastructure clinically significant depressive symptoms disease classification early childhood early onset experience functional disability heuristics improved indexing neural circuit neurobehavioral neurophysiology relating to nervous system treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Childhood mood disorders represent a significant public health concern, with 6 to 11% of the population suffering from symptomology. Among those affected, 70% will have a recurrence during childhood and/or adolescence, and 50% will continue to experience symptoms in adulthood. These patterns of chronicity suggest that mental health problems observed later in life often have identifiable markers during early childhood. Therefore, early identification and intervention is critical. The NIH has put forth the Research Domain Criteria (RDoC), which acts as a heuristic to examine mechanisms of mental illness by suggesting the investigation of several behaviorally and biologically based processes. Although RDoC provides a valuable theoretical framework, the applicability of RDoC for developmental psychopathology research has been limited, primarily due to a lack of validated, feasible, standardized assessment batteries to examine RDoC domains in young children. Our aim is to create and validate behavioral and neurobiological assessments for young children in order to examine the relevance of RDoC domains, Positive and Negative Valence, for childhood depression and anxiety that often precedes or commingles with it. Specifically, we will study the constructs of reward valuation (Positive Valence) and acute threat (Negative Valence) using behavioral and neurophysiologic correlates of these constructs and test for associations with clinically assessed depression and anxiety in 4-6 year old children. Recruitment through the Infant and Early Childhood Clinic at the University of Michigan's Department of Psychiatry, as well as general pediatrics clinics in our health system, will ensure that a broad spectrum of anxiety and depressive symptoms, across the clinical to non-clinical range are represented in the children in our study. We seek NIH pilot funding to investigate the feasibility of behavioral and neurophysiology tasks that will long-term 1) inform assessment procedures, blending basic science advances with accessibility for patients and their families; 2) improve our characterization of underlying mechanisms of child anxiety and depression; and 3) inform subsequent interventions to address personalized child-level deficits. Findings will prove high impact as the NIMH considers the study and future application of RDoC criteria a high priority, and, yet, there are few empirical data exploring such application among young children. This proposal is responsive to the urgent need for validated, feasible, and standardized assessment batteries to examine RDoC domains in young children, and represents a critical step in a long-term plan to achieve effective and mechanism-based identification and treatment strategies for preschool-age children with depression and anxiety.

描述（由申请人提供）：儿童情绪障碍是一个重大的公共卫生问题，有6％至11％的人口患有症状。在受影响的人中，有70％的儿童和/或青春期会复发，而50％的人将继续经历成年后的症状。这些慢性的模式表明，在幼儿期间，生活后期观察到的心理健康问题通常具有可识别的标记。因此，早期识别和干预至关重要。 NIH提出了研究领域的标准（RDOC），该标准是一种启发式方法，可以通过建议研究几种基于行为和生物学的过程来检查精神疾病的机制。尽管RDOC提供了有价值的理论框架，但RDOC在发育心理病理学研究中的适用性受到限制，这主要是由于缺乏经过验证，可行的，标准化的评估电池来检查幼儿的RDOC领域。我们的目的是为幼儿创建和验证行为和神经生物学评估，以检查RDOC领域，正值和负面价与儿童抑郁症和焦虑的相关性，这些抑郁症和焦虑往往与其相关。具体而言，我们将使用这些结构的行为和神经生理学相关性研究奖励估值（正价）和急性威胁（负价）的结构，并测试与4-6岁儿童临床评估的抑郁症和焦虑的关联。密歇根大学精神病学系的婴儿和幼儿诊所的招募以及我们卫生系统中的普通儿科诊所将确保在我们的研究中，跨临床到非临床范围的临床至非临床范围的各种焦虑和抑郁症状。我们寻求NIH试点资金来研究行为和神经生理学任务的可行性，这些任务将长期1）为评估程序提供信息，将基础科学进步与患者及其家人的可及性相结合； 2）提高我们对儿童焦虑和抑郁机制的表征； 3）告知随后的干预措施以解决个性化的儿童级缺陷。由于NIMH认为RDOC标准的研究和未来应用是很高的优先级，因此发现将被证明很大，但是，很少有经验数据探讨幼儿中这种应用。该提案响应迫切需要对幼儿检查RDOC领域的经过验证，可行和标准化的评估电池，并代表了长期计划中的关键步骤，以实现抑郁症和焦虑症的学龄前儿童的有效和机制的识别和治疗策略。