Carbon Nanotube Sensor Array for Sensitive Detection of Mercury Poisoning

用于汞中毒灵敏检测的碳纳米管传感器阵列

基本信息

批准号：
8643722
负责人：
Maksudul Alam
金额：
$ 24.16万
依托单位：
INNOSENSE, LLC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-28 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8643722
关键词：
Acids Adsorption Affect Air American Bedside Testings Binding Biological Assay California Carbon Nanotubes Cardiovascular system Cessation of life Chemical Engineering Chemicals Chronic Kidney Failure Clinical Trials Clinics and Hospitals Communities Companions Congenital Abnormality Cost Effectiveness Analysis Coupled Detection Development Devices Diagnostic Electrodes Electronics Engineering Ensure Environmental Engineering technology Equipment Esters Ethanolamines Evaluation Exposure to Fluorescence Spectroscopy Food Food Chain Foundations Gold Health Hexanols Human Human body In Situ Industry Intestines Ions Kidney Kidney Failure Laboratories Life Liver Maintenance Mercury Mercury Poisoning Metals Methods Methylmercury Compounds Minamata Disease Mining Monitor Nanotechnology Nervous System Trauma Neurologic Numbness Oligonucleotides Organism Patient Care Performance Phase Plasma Point-of-Care Systems Poison Poisoning Principal Investigator Private Practice Procedures Process Qualifying Reproducibility Research Resistance Risk Running Sampling Site Soil Surface Symptoms System Tail Testing Time Toxic effect Toxin Training Tweens United States United States Environmental Protection Agency Universities Urine Visual Visual impairment Water artist base bioaccumulation cost effective drinking water drug discovery improved laboratory facility liver injury meetings migration monolayer nanoparticle point of care prevent professor prototype public health relevance response sensor single walled carbon nanotube socioeconomics success tool vapor water quality water sampling

项目摘要

DESCRIPTION (provided by applicant): Mercury (Hg) has been recognized as having serious impacts on human health due to its toxicity and bioaccumulation via the food chain. Elevated exposure to Hg can affect the liver, kidneys, and cardiovascular, gastro-intestinal, and neurological systems of the human body. Inorganic Hg (Hg2+) can cause chronic kidney disease (CKD) and kidney failure. Methylmercury (CH3Hg+), an organic form of Hg, is highly toxic to living systems. CH3Hg+ causes nervous system damage leading to problems with coordination, numbness, and visual impairment. Death from CH3Hg+ poisoning usually occurs 2-4 days after the first symptoms occur. Therefore, detecting CH3Hg+ and Hg2+ ions is highly important to human health. Currently, there is no simple, point of care (POC) system for detecting these toxins. To meet this need, InnoSense LLC (ISL) aims to develop a carbon nanotube-based MerSense" assay for cost-effective, POC detection of CH3Hg+ and Hg2+ ions with high sensitivity and selectivity. The purpose of the Phase I project is to establish that a MerSense sensor array can accurately detect CH3Hg+ and Hg2+ ions in artificial urine samples. In Phase I, ISL will fabricate and test the MerSense sensor array for detecting trace levels of CH3Hg+ and Hg2+ (d2 ppb) in artificial urine. ISL will also evaluate MerSense performance and demonstrate the sensitivity, selectivity, accuracy, reliability, reproducibility, and real-time sensing capability. Successful development of ISL's MerSense and demonstration of its enhanced performance for Hg detection will have widespread socioeconomic benefits: (1) a simple and cost-effective POC test for improved patient care in clinics, hospitals, private-practice facilities and laboratories, (2) a companion diagnostic tool for pharma and biotech drug discovery and clinical trial research, (3) a new research tool for the scientific community, (4) cost-effective analysis of tailing ponds and run-off in the mining industry for toxic Hg contamination, (5) testing and monitoring drinking water quality by State and Federal agencies, and humanitarian organizations, and (6) trace level detection of Hg at the point of migration to food (air, water and soil) as well as in metal processing, chemical manufacturing and electronics industries.

描述（由申请人提供）：汞 (Hg) 因其毒性和通过食物链的生物累积性而被认为对人类健康具有严重影响。汞暴露水平升高会影响人体的肝脏、肾脏、心血管、胃肠道和神经系统。无机汞 (Hg2+) 可导致慢性肾病 (CKD) 和肾衰竭。甲基汞 (CH3Hg+) 是汞的有机形式，对生命系统具有剧毒。 CH3Hg+ 会导致神经系统损伤，导致协调问题、麻木和视力障碍。 CH3Hg+ 中毒导致的死亡通常发生在首次症状出现后 2-4 天。因此，检测CH3Hg+和Hg2+离子对人类健康非常重要。目前，还没有简单的护理点 (POC) 系统来检测这些毒素。为了满足这一需求，InnoSense LLC (ISL) 旨在开发一种基于碳纳米管的 MerSense" 检测方法，以高灵敏度和选择性对 CH3Hg+ 和 Hg2+ 离子进行经济有效的 POC 检测。第一阶段项目的目的是确定MerSense 传感器阵列可以准确检测人造尿液样本中的 CH3Hg+ 和 Hg2+ 离子在第一阶段，ISL 将制造和测试 MerSense 传感器阵列，用于检测痕量 CH3Hg+ 和 Hg2+ 离子。 ISL 还将评估人工尿液中的 Hg2+ (d2 ppb) 性能，并展示 ISL MerSense 的灵敏度、选择性、准确性、可靠性、再现性和实时传感能力，并展示其增强的汞检测性能。具有广泛的社会经济效益：(1) 一种简单且经济有效的 POC 测试，可改善诊所、医院、私人诊所和实验室的患者护理，(2) 用于制药和生物技术药物发现的伴随诊断工具和临床试验研究，(3) 科学界的新研究工具，(4) 对尾矿库和采矿业径流中有毒汞污染进行成本效益分析，(5) 通过以下方法测试和监测饮用水质量：州和联邦机构以及人道主义组织，以及 (6) 汞迁移至食品（空气、水和土壤）以及金属加工、化学制造和电子行业时的痕量水平检测。