Development of Networked Implantable Neuroprostheses

网络化植入式神经假体的开发

• 批准号: 8464098
• 负责人: Paul Hunter Peckham
• 金额: $ 63.75万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-24 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464098
• 关键词: Activities of Daily Living; Algorithms; Bathing; Central Nervous System Diseases; Cervical; Cervical spinal cord injury; Clinical; Clinical Research; Computer software; Development; Elbow; Electric Stimulation; Electrodes; Feasibility Studies; Forearm; Funding; Generations; Goals; Hand; Hand functions; Home environment; Human; Impairment; Implant; Individual; Lead; Measures; Muscle; National Institute of Biomedical Imaging and Bioengineering; Nature; Outcome Assessment; Paralysed; Pattern; Performance; Process; Pronation; Publishing; Quality of life; Shoulder; Signal Transduction; Skin; Spinal cord injury; Stimulus; Swimming; System; Technology; Testing; Upper Extremity; arm; clinical application; computerized data processing; design; functional outcomes; functional restoration; grasp; improved; improved functioning; instrument; neuroprosthesis; programs; tool

DESCRIPTION (provided by applicant): This project is a feasibility clinical study of the upper extremity Networked Neuroprosthetic (NNP) System to demonstrate efficacy in providing grasp and reach for individuals with cervical level spinal cord injury. The NNP System will electrically stimulate paralyzed muscles in a coordinated fashion to provide grasp and release, forearm pronation, elbow extension, and shoulder/trunk stabilization. The stimulated patterns will be controlled by each subject through activation of their voluntary musculature, as recorded through implanted myoelectric recording electrodes. Subject performance will be assessed through measures of impairment, activities, and participation, with a focus on the ability to perform activities of daily living more independently and on the rate of daily home use. We hypothesize that daily usage will be improved due to the fully implantable nature of the NNP System and that every subject will improve in their functional ability, regardless of their startin function level, due to the modular and customizable nature of the NNP System.

描述（由申请人提供）：该项目是上肢网络神经假体（NNP）系统的可行性临床研究，以证明在提供掌握脊髓损伤的个体的掌握和覆盖方面的功效。 NNP系统将以协调的方式刺激瘫痪的肌肉，以提供掌握和释放，前臂旋前，肘部伸展以及肩部/躯干稳定。通过植入的肌电记录电极记录，每个受试者将通过激活其自愿性肌肉来控制刺激的模式。主题绩效将通过损害，活动和参与度的措施进行评估，重点是更独立地进行日常生活活动和日常家庭使用率。我们假设由于NNP系统的完全可植入的性质，每日使用将得到改善，并且由于NNP系统的模块化和可定制的性质，每个受试者的功能能力都将提高其功能能力。