Multi-functional Neuroprosthetic Systems for Restoration of Motor Function

用于恢复运动功能的多功能神经假体系统

• 批准号: 8689184
• 负责人: Paul Hunter Peckham
• 金额: $ 133.39万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689184
• 关键词: Address; Advanced Development; Beds; Bilateral; Bladder; Bladder Control; Cervical; Cervical spinal cord injury; Clinical; Clinical Research; Coughing; Coupled; Development; Disabled Persons; Feasibility Studies; Foundations; Funding; Goals; Hand; Hand functions; Health; Human; Implant; Individual; Injury; Instruction; Intestines; Leg; Motor; Movement; Musculoskeletal Equilibrium; Operative Surgical Procedures; Outcome; Outcome Assessment; Paralysed; Posture; Preparation; Quadriplegia; Quality of life; Research; Spinal cord injury; System; Techniques; Technology; Testing; base; functional gain; functional outcomes; gain of function; grasp; hand grasp; human subject; implantation; in vivo; meetings; multiple disability; neuroprosthesis; preclinical study; respiratory; restoration

Traumatic cervical-level spinal cord injury can result in permanent and extensive paralysis below the level of injury, causing the loss of multiple body functions, including hand, trunk and leg movement, bladder and bowel control, and respiratory capacity. The goal of this project is to restore these multiple functions to these individuals through a comprehensive neuroprosthetic approach that addresses the overall needs of the individual. This approach involves all aspects of the implementation, including the implanted technology, the surgical installation, and the outcomes assessment through a coordinated team approach in order to maximize the functional independence gained by the individual. With this system, we intend to provide individuals who have a mid-cervical level spinal cord injury with control over grasp, reach, cough, turning in bed, seated posture, and bladder function. This ambitious and exciting goal is made possible by the culmination of our research and clinical deployment of neuroprosthetic systems for spinal cord injured subjects over the past 30 years and our development of an advanced neuroprosthesis. We anticipate that this system will not only provide increased independence in each of the targeted body functions, but will provide an overall benefit to demonstrate significant improvements in quality of life and health outcomes. In clinical feasibility studies with spinal cord injured subjects, our clinical research teams have demonstrated the control of bilateral hand function, rolling and postural control, cough, bladder control and bowel control using chronically implanted neuroprostheses. Outcomes from each clinical study demonstrate that each system provides increased functional independence to the individual. However, to this point, it has not been possible to address each individual's holistic needs and tailor an overall approach that maximizes the function gained. Through the development of a Networked Neuroprosthetic System (NNPS), we now have the technological foundation for a multi-functional system. The strategy employed in this U01 project is to finalize the key components of our proposed holistic neuroprosthetic approach. Thus, each component of the approach, including the technology, regulatory approvals, surgical installation, outcome assessment and overall implementation, will be brought to completion during this project, culminating in the implementation of the multi-function NNPS in spinal cord injured subjects. The ultimate outcome of this project is that we will demonstrate the feasibility of addressing multiple disabilities in severely disabled individuals using an advanced neuroprosthetic system coupled with a streamlined and cohesive implementation strategy.

创伤性宫颈水平脊髓损伤可能导致低于水平的永久和广泛的麻痹 受伤，导致多个身体功能的丧失，包括手，躯干和腿部运动，膀胱和 肠道控制和呼吸能力。该项目的目的是将这些多个功能恢复到这些功能 通过一种全面的神经假体方法来满足的整体需求 个人。这种方法涉及实施的各个方面，包括植入技术， 手术安装，以及通过协调的团队方法进行的结果评估，以便 最大化个人获得的功能独立性。有了这个系统，我们打算提供 患有中腹级脊髓损伤的个体，可以控制掌握，触及，咳嗽，上交 床，坐姿和膀胱功能。这个雄心勃勃的令人兴奋的目标使 我们研究和临床部署神经假体系统的脊髓受伤的最终 在过去的30年中，受试者以及我们发展了先进的神经假体。我们预料到这一点 该系统不仅将提供每个目标身体功能的独立性，还将 提供总体好处，以证明生活质量和健康成果的显着改善。 在脊髓受伤受试者的临床可行性研究中，我们的临床研究小组有 证明了双边手部功能，滚动和姿势控制，咳嗽，膀胱控制和 使用慢性植入神经假体的肠道控制。每个临床研究的结果表明 每个系统都为个人提供了增加的功能独立性。但是，至此，它有 无法满足每个人的整体需求，并量身定制一种最大化的方法 获得的功能。通过开发网络神经假体系统（NNP），我们现在 具有多功能系统的技术基础。该U01项目中采用的策略是 最终确定我们提出的整体神经假体方法的关键组成部分。因此， 该方法，包括技术，法规批准，手术安装，结果评估和 总体实施将在此项目期间完成，最终实施 脊髓损伤受试者中的多功能NNP。该项目的最终结果是我们将 证明使用一个严重残疾的人解决多重残疾的可行性 高级神经假体系统，加上流线型和凝聚力的实施策略。