Bone Mineral Accretion in Young Children

幼儿骨矿物质沉积

• 批准号: 8631290
• 负责人: Heidi J Kalkwarf
• 金额: $ 100.88万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8631290
• 关键词: 5 year old; Accounting; Address; Affect; Age; Body Composition; Bone Density; Bone Development; Bone Growth; Bone Mineral Contents; Cancer Survivor; Caring; Characteristics; Child; Child Care; Childhood; Chronic; Chronic Disease; Clinical; Clinical Treatment; Clinical assessments; Collaborations; Crohn' s disease; Data; Development; Dietary intake; Disease; Dual-Energy X-Ray Absorptiometry; Female; Fracture; Gastrointestinal Diseases; Glare; Glucocorticoids; Goals; Growth; Health; Health Care Costs; Health Status; Interdisciplinary Study; Kidney Diseases; Knowledge; Length; Locomotion; Longitudinal Studies; Measurement; Measures; Mechanics; Medical; Methods; Minerals; Mission; Monitor; Morbidity - disease rate; Motor; Motor Skills; Musculoskeletal Diseases; Neuromuscular Diseases; Osteoporosis; Outcome; Pattern; Personal Satisfaction; Physical activity; Predisposition; Public Health; Race; Recording of previous events; Research; Risk; Risk Factors; Scanning; Site; Skeleton; Sleep; Staging; Techniques; Testing; Time; Tissues; Walking; Weight; age group; bone; bone health; bone strength; calcium intake; clinical application; clinically relevant; density; early childhood; improved; infancy; male; novel; premature; prevent; public health relevance; rapid growth; response; restricted physical activity; sex; skeletal

PROJECT SUMMARY Children with chronic medical conditions are at risk of compromised bone strength and increased fracture susceptibility. Recently developed reference data have enabled clinicians to identify children 5 to 20 y with compromised bone mineral status (low bone density for age) and optimize their medical care. A glaring deficit is the inability to evaluate bone health of young children < 5 y due to lack of appropriate bone density reference data, although numerous clinical conditions (e.g., prematurity, gastrointestinal and neuromuscular disorders) threaten bone health in this young age range. Early childhood differs from other developmental stages. In older children, the need to account for growth status and lean mass when interpreting bone measurements has been demonstrated, but in early childhood, these effects are unknown. Pronounced changes in gross motor skills, locomotion and physical activity also occur in early childhood. Mechanical loads on the growing skeleton promote bone mineral accrual. Understanding the impact of growth, body composition, motor skill development, and physical activity on bone accrual in young children is critical for interpretation of a clinical bone mineral status measurement. These characteristics are often affected in young children with chronic medical conditions. The long-term goal of this study is to optimize bone health of young children. The objectives of this longitudinal study are to develop regional and total body bone mineral content (BMC) and density (aBMD) reference data for children ages 1-5 y to aid identification of young children with bone deficits, and identify factors that influence bone accrual in this age group. The aims of this longitudinal study are: (1) test for sex and ancestry differences in BMC and aBMD at multiple skeletal sites in healthy children ages 1 to 5 y, and create appropriate reference curves; (2) assess the influence of growth and body composition, and (3) gross motor skills and physical activity on bone mineral status and bone mineral accrual, and (4) determine the degree of "tracking" of bone status in young children. Hypotheses to be tested are: males will have greater BMC and aBMD than females; Blacks will have greater BMC and aBMD than non-blacks; bone mineral status and bone accrual will be greater in children with greater growth status and more lean tissue, more advanced gross motor skills, and higher physical activity levels; and BMC and aBMD z-scores will be positively correlated over 3 y. The study is unique since no previous studies have addressed these issues in children 1-5 y. It is clinically relevant as findings will facilitate medical care of children with chronic medical conditions that threaten bone health, and it will develop and validate novel methods for bone and body composition assessment in this age range. It will also add generalizable knowledge to enhance understanding of the growing skeleton, and its relationship to motor and somatic development. Since poor bone mineral accrual can have lifelong consequences, this study addresses the major public health concern of osteoporosis.

患有慢性医疗状况的项目摘要儿童有骨骼强度受损的风险 并增加了断裂敏感性。最近开发的参考数据使临床医生能够识别 5至20 y的儿童骨矿物质状态受损（年龄低骨密度），并优化其医疗 关心。明显的赤字是由于缺乏适当的 骨密度参考数据尽管众多临床条件（例如，早产，胃肠道和 神经肌肉疾病）威胁到这个年轻时的骨骼健康。 幼儿期与其他发展阶段不同。在年龄较大的孩子中，需要考虑增长 解释骨骼测量时的状态和瘦质量已被证明，但在童年时期， 这些效果未知。明显的总体运动技能，运动和体育锻炼的变化也发生了变化 发生在幼儿时期。生长的骨骼上的机械载荷可促进骨矿物质应计。 了解生长，身体成分，运动技能发展和体育锻炼对骨骼的影响 幼儿的应计对解释临床骨矿物质状态测量至关重要。这些 患有慢性医疗状况的幼儿通常会影响特征。 这项研究的长期目标是优化幼儿的骨骼健康。目标的目标 纵向研究是为了发展区域和总体骨矿物质含量（BMC）和密度（ABMD） 1-5岁儿童的参考数据，以帮助识别骨缺陷的幼儿，并确定 影响该年龄段的骨骼应计的因素。这项纵向研究的目的是：（1）性别测试 在1至5年健康儿童中多个骨骼部位的BMC和ABMD的祖先差异，并且 创建适当的参考曲线； （2）评估生长和身体成分的影响，（3） 运动技能和骨矿物质状态和骨矿物质的体育锻炼，（4）确定 幼儿骨骼状况的“跟踪”程度。要测试的假设是：男性会有更大的 BMC和ABMD比女性；黑人将拥有比非黑人更大的BMC和ABMD。骨矿物质状态 在具有更大生长状态且更瘦的组织的儿童中，骨骼应计会更大，更先进 总体运动技能和较高的体育锻炼水平； BMC和ABMD Z分数将呈正相关 超过3年。这项研究是独一无二的，因为以前没有研究在1-5岁的儿童中解决了这些问题。这是 在临床上相关，因为发现将促进患有慢性医疗状况的儿童的医疗服务 威胁骨骼健康，它将开发和验证骨骼和身体成分的新方法 在这个年龄范围内的评估。它还将增加可推广的知识，以增强对 不断增长的骨骼及其与运动和躯体发育的关系。由于骨矿物质不良可以 有终生的后果，这项研究解决了骨质疏松症的主要公共卫生问题。