Comprehensive Cancer Center Program at Fox Chase

福克斯蔡斯综合癌症中心项目

• 批准号: 8894659
• 负责人: RICHARD I FISHER
• 金额: $ 12.5万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-21 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8894659
• 关键词: Applications Grants; Appointment; Area; Cancer Center; Cancer Center Support Grant; Comprehensive Cancer Center; Core Facility; Development; Diagnosis; Elements; Evaluation; Exclusion; Fox Chase Cancer Center; Foxes; Funding; Future; Grant; Heart; Investments; Laboratories; Leadership; Malignant Neoplasms; Marshal; Medical; Medicine; Mind; Mission; Monitor; NCI-Designated Cancer Center; Nature; Peer Review; Philadelphia; Prevention approach; Prevention strategy; Principal Investigator; Process; Program Research Project Grants; Protocols documentation; Recommendation; Recruitment Activity; Request for Proposals; Research; Research Personnel; Resources; Science; Source; System; Vision; anticancer research; base; cancer care; comparative; meetings; programs

DESCRIPTION (provided by applicant): The Fox Chase Cancer Center is under new leadership since the last review and continues as one of the nation's few free standing comprehensive cancer centers. The Center's mission is "To prevail over cancer, marshaling excellence of heart and mind each day in the collaborative practice of bold scientific discovery, prevention strategies, and compassionate cancer care." Our vision is to be an acknowledged national leader in cancer research and medicine and a pre-eminent cancer center in the Philadelphia area. The new leadership in conjunction with advice from External Advisory Boards has consolidated the CCSG Research Programs from 11 to 5. These five Programs represent the core scientific strengths of the Fox Chase Cancer Center. At the last review 30 CCSG Shared Facilities and 2 support elements (Protocol Review and Monitoring System and Protocol Specific Research) were approved for funding with recommendations to consolidate facilities. This proposal requests partial support for 16 core facilities and 2 support elements. Developmental Funds are requested to strategically increase critical mass for these 5 research Programs over the CCSG funding cycle. A plan is presented to recruit 21 to 30 new and replacement investigators. In the past CCSG cycle, 40 investigators were recruited and, with the exclusion of our 17 newest recruits, 19 of 23 (83%) have obtained $15.4 million in peer-reviewed funding within 24 months of their appointment. Of that amount $5.1 million was garnered by investigators who were partially supported by Developmental Funds. Since the last submission, the Cancer Research Pavilion was completed as planned in 2010 and will provide much of the needed space for new investigator laboratories. The Leadership's vision includes a plan to increase team-based science via strategic keystone investments. These institutional investments are intended to expand the research portfolio of FCCC to include more "team-based" grants such as Program Project Grants and SPOREs. Several team-based science grant proposals will be submitted over the next few years as a direct result of these keystone Investments. To meet the demand presented by a future increase in principal investigators, the Center plans to leverage $8 million of ARRA funds with $5.1 million of institutional investment to construct a Comparative Medical Facility (CMR). Since the last review, FCCC has implemented a formal review mechanism to evaluate and prioritize its CCSG Shared Research Resources. As a result, of this evaluation process, the number of Shared Research Resources has been streamlined.

描述（由申请人提供）：自上次审查以来，福克斯蔡斯癌症中心处于新的领导之下，并继续作为全国为数不多的独立综合癌症中心之一。该中心的使命是“战胜癌症，每天通过大胆的科学发现、预防策略和富有同情心的癌症护理的合作实践，展现卓越的心灵和思想。”我们的愿景是成为癌症研究和医学领域公认的全国领导者以及费城地区卓越的癌症中心。新领导层结合外部顾问委员会的建议，将 CCSG 研究项目从 11 个合并为 5 个。这 5 个项目代表了 Fox Chase 癌症中心的核心科学优势。在上次审查中，30 个 CCSG 共享设施和 2 个支持要素（方案审查和监测系统以及方案特定研究）获得批准，并提出了合并设施的建议。该提案要求对 16 个核心设施和 2 个支持要素提供部分支持。请求发展基金在 CCSG 资助周期内战略性地增加这 5 个研究计划的临界质量。计划招募 21 至 30 名新的和替代的调查员。在过去的 CCSG 周期中，招募了 40 名调查员，排除我们最新招募的 17 名调查员，23 名调查员中的 19 名 (83%) 在任命后 24 个月内获得了 1,540 万美元的同行评审资金。其中 510 万美元是由调查人员获得的，他们的部分资金来自发展基金。自上次提交以来，癌症研究馆已按计划于 2010 年竣工，将为新的研究实验室提供大部分所需的空间。领导层的愿景包括一项通过战略重点投资来增强基于团队的科学的计划。这些机构投资旨在扩大 FCCC 的研究组合，以包括更多“基于团队”的资助，例如计划项目资助和 SPORE。作为这些重点投资的直接结果，未来几年将提交几项基于团队的科学资助提案。为了满足未来主要研究者增加的需求，该中心计划利用 ARRA 资金 800 万美元，机构投资 510 万美元，用于建设比较医疗设施 (CMR)。自上次审查以来，FCCC 实施了正式的审查机制来评估其 CCSG 共享研究资源并确定其优先顺序。因此，在本次评估过程中，共享研究资源的数量得到了精简。