SPORE in Lymphoma

淋巴瘤中的孢子

• 批准号: 7681128
• 负责人: RICHARD I FISHER
• 金额: $ 230万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7681128
• 关键词: SPORE; Lymphoma; SPORE; Lymphoma

DESCRIPTION (provided by applicant): This Lymphoma SPORE application from the James P. Wilmot Cancer Center (JPWCC), University of Rochester, and the Arizona Cancer Center (ACC), University of Arizona provides a broad based, translational research program studying several major unresolved issues in the lymphoma biology. Specifically the projects will focus on several novel, targeted therapeutic agents either in development or approved for the treatment of three of the most common non-Hodgkin's lymphomas, namely diffuse large B-cell, follicular and mantle cell lymphoma. We will initially seek to elucidate mechanisms of action and/or resistance both in vitro, and in carefully developed model systems; then pilot clinical trials with an emphasis on correlative studies will be designed and conducted to validate these mechanisms. Investigators at the JPWCC and the ACC, long-time collaborators, lead each of the programs. The clinical and pathologic resources of the Lymphoma Committee of the Southwest Oncology Group are also integrated into this program. Projects include: Research Project 1: Targeting Aurora Kinase in Aggressive B-cell non-Hodgkin's Lymphoma, Project 2: Optimizing Redox Modulation as a Therapeutic Strategy for NHL. Project 3: Potentiating Proteasome Inhibitor Activity in NHL. Project 4: Characterization of Lymphoma-lnitiating Cells.

描述（由申请人提供）：罗切斯特大学詹姆斯·威尔莫特癌症中心（JPWCC）和亚利桑那州癌症中心（ACC）的这种淋巴瘤孢子应用，亚利桑那大学提供了一项基于广泛的转化研究计划，研究了淋巴瘤生物学中几个主要未解决的问题。具体而言，这些项目将集中在开发或批准的几种新型的，有针对性的治疗剂上，以治疗三种最常见的非霍奇金淋巴瘤，即弥漫大型B细胞，卵泡和地幔细胞淋巴瘤。我们最初将寻求在体外和精心开发的模型系统中阐明作用和/或抗性机制。然后，将设计和进行强调相关研究的试验临床试验，以验证这些机制。 JPWCC和ACC的调查人员，长期合作者主持了每个计划。西南肿瘤学组淋巴瘤委员会的临床和病理资源也已纳入该计划。项目包括： 研究项目1：靶向激进的B细胞非霍奇金淋巴瘤中的Aurora激酶，项目2：优化氧化还原调节作为NHL的治疗策略。项目3：增强NHL中蛋白酶体的抑制剂活性。项目4：淋巴瘤 - 元素细胞的表征。