Self-Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Rural C

自行佩戴式超声治疗在农村地区治疗骨关节炎

基本信息

批准号：
8740552
负责人：
George Kenneth Lewis
金额：
$ 20万
依托单位：
ZETROZ, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-24 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8740552
关键词：
Acoustics Adherence Adverse effects Affect Age-Years American Analgesics Animals Anxiety Area Bandage Cartilage Charge Clinic Clinical Research Communities Coupling Data Data Analyses Degenerative polyarthritis Development Devices Disadvantaged Doctor of Philosophy Double-Blind Method Effectiveness Electronics Engineering Enrollment Evaluation Fracture Fracture Healing Frequencies Funding Gel Goals Healthcare Healthcare Systems Hip region structure Home environment Hour Human Human body Individual Inflammation Insurance Coverage Joints Knee Knee Osteoarthritis Mechanics Mediating Medicine Mental Depression Miniaturization Monitor Morbidity - disease rate Musculoskeletal Pain Ointments Opioid Outcome Study Outpatients Pain Pain management Patients Penetration Persistent pain Pharmaceutical Preparations Pharmacologic Substance Phase Physiology Placebos Population Power Sources Price Public Health Quality of life Radiology Specialty Randomized Recording of previous events Reporting Research Rural Rural Population Secure Skin Sleep disturbances Solutions Sports System Target Populations Technology Testing Therapeutic Training Transducers Translational Research Translations Treatment Effectiveness Ultrasonic Therapy Ultrasonic Transducer Ultrasonography United States United States National Institutes of Health Visual Work addiction analog arthritis therapy chronic pain commercialization cost design dosimetry effective therapy engineering design ergonomics experience improved improved mobility innovation placebo controlled study primary outcome public health relevance research clinical testing socioeconomics usability user-friendly wound

项目摘要

DESCRIPTION (provided by applicant): Persistent pain is the number one reason that patients access the healthcare system according to the National institutes of Health. Pain seriously affects patients' quality of life and is associated with secondary morbidities such as depression, anxiety, and sleep disturbance. Medications are often the first-line treatment for pain relief, but they are not without serious side effects. Particularly for rural citizens and socioeconomic disadvantaged individuals very few non-pharmacotherapy regimes exist to help manage pain. Ultrasound has been used safely and effectively for years to provide pain relief. Additionally, the mechanical and thermal mechanisms of action in ultrasound have been shown to facilitate wound and bone fracture healing, to promote the penetration of topical ointments into the skin and found to enhance a variety healthcare applications. Despite the potential of ultrasound therapy, the size, price, and mode of delivery has prohibited its broad translation. We have developed a new ultrasound device that provides a unique platform solution for ultrasound in frontline medicine in disparate and socioeconomic disadvantaged communities. The system relies on aggressive miniaturization and integration of the ultrasound transducer, electronics, and power supply to produce an iPod- sized low-intensity ultrasound system that can deliver portable, convenient, and effective therapy for long durations. For this project, the iPod-sized ultrasound devices will be refined and clinically evaluated on subjects with osteoarthritis of the knee. Subjects will be asked to wear the device for 6 hours a day over the duration of the study, and will be monitored for reductions in pain, increased mobility and their use of pharmaceuticals for pain control. Successful completion of the study will increase scientific understanding of the efficacy of low- intensity continuous ultrasound treatment on musculoskeletal pain and mobility from OA, and provide the first non-invasive, portable, transformative solution to pain control.

描述（由申请人提供）：持续性疼痛是患者根据美国国立卫生研究院获得医疗保健系统的第一原因。疼痛严重影响患者的生活质量，并与抑郁症，焦虑和睡眠障碍等继发性病有关。药物通常是缓解疼痛的一线治疗方法，但并非没有严重的副作用。特别是对于农村公民和社会经济不利的人来说，很少有非药物治疗方案有助于管理疼痛。多年来，超声已经安全有效地使用了疼痛。此外，超声波中的机械和热机制已显示出促进伤口和骨断裂愈合，以促进局部软膏渗透到皮肤中，并发现增强了多样性的医疗保健应用。尽管有超声疗法的潜力，但规模，价格和交付方式仍禁止其广泛的翻译。我们已经开发了一种新的超声设备，该设备为在不同和社会经济不利的社区中的前线医学中提供了独特的平台解决方案。该系统依靠超声传感器，电子设备和电源的积极小型化和整合来产生iPod型的低强度超声系统，该系统可以长期提供便携式，方便且有效的治疗。对于该项目，将对iPod大小的超声设备进行完善，并对患有膝关节骨关节炎的受试者进行临床评估。在研究期间，将要求受试者每天佩戴该设备6个小时，并将受到监控，以减轻疼痛，迁移率增加以及使用药物来控制疼痛。该研究的成功完成将增加对低强度连续超声处理对肌肉骨骼疼痛和OA迁移率的疗效的科学理解，并提供第一种非侵入性，便携式，可变性的解决方案来控制疼痛。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Human Factors Engineering and testing for a wearable, long duration ultrasound system self-applied by an end user.

由最终用户自行应用的可穿戴式长持续时间超声系统的人为因素工程和测试。

DOI：
10.1109/embc.2014.6943651
发表时间：
2014
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Taggart,Rebecca;Langer,MatthewD;LewisJr,GeorgeK
通讯作者：
LewisJr,GeorgeK

Therapeutic ultrasound: myths and truths for non-portable in-clinic and portable home use ultrasound.

治疗性超声：非便携式诊所和便携式家用超声的神话与真相。

DOI：
发表时间：
2020
期刊：
MOJ sports medicine
影响因子：
0
作者：
Draper,David;Mallipudi,RajivM
通讯作者：
Mallipudi,RajivM

Pilot Clinical Studies of Long Duration, Low Intensity Therapeutic Ultrasound for Osteoarthritis.

长持续时间、低强度超声治疗骨关节炎的试点临床研究。

DOI：
10.1109/nebec.2014.6972850
发表时间：
2014
期刊：
Proceedings of the IEEE ... annual Northeast Bioengineering Conference. IEEE Northeast Bioengineering Conference
影响因子：
0
作者：
Langer,MatthewD;Levine,Vanessa;Taggart,Rebecca;Lewis,GeorgeK;Hernandez,Lyndon;Ortiz,Ralph
通讯作者：
Ortiz,Ralph

Low Intensity Ultrasound for Promoting Soft Tissue Healing: A Systematic Review of the Literature and Medical Technology.