Advancing MRI & MRS Technologies for Studying Human Brain Function and Energetics

推进核磁共振成像

• 批准号: 8827010
• 负责人: Wei Chen
• 金额: $ 46.87万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8827010
• 关键词: Address; Adenosine Triphosphate; Biological Neural Networks; Brain; Brain imaging; Brain region; Cerebrovascular Circulation; Cerebrum; Characteristics; Clinical; Complement; Cortical Column; Detection; Development; Diffusion weighted imaging; Dimensions; Engineering; Functional Magnetic Resonance Imaging; Functional disorder; Generations; Geometry; Grant; Heating; Human; Human body; Image; Imaging Device; Imaging Techniques; Imaging technology; Institution; Interdisciplinary Study; Intramural Research; Lead; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Medicine; Metabolic; Minnesota; Monitor; Monoclonal Antibody R24; Neurosciences; Neurosciences Research; Nicotinamide adenine dinucleotide; Noise; Nuclear; Organ; Outcome; Oxidation-Reduction; Oxygen; Oxygen Consumption; Paris, France; Performance; Photic Stimulation; Physics; Physiology; Pilot Projects; Process; Reproducibility; Research; Research Project Grants; Resolution; Rest; Risk; Safety; Science; Signal Transduction; Solutions; Structure; System; Techniques; Technology; Testing; Tissues; Translational Research; United States National Institutes of Health; Universities; Visual Cortex; Work; absorption; base; brain metabolism; brain research; clinical Diagnosis; cost effective; disease diagnosis; improved; in vivo; innovation; innovative technologies; instrument; interest; magnetic field; nervous system disorder; neural circuit; neurochemistry; neuroimaging; next generation; novel; prototype; public health relevance; radiofrequency; relating to nervous system; response; transmission process

 DESCRIPTION (provided by applicant): Magnetic resonance (MR) imaging (MRI) and in vivo MR spectroscopy (MRS) techniques have become indispensable tools for imaging brain structure, function, connectivity, neurochemistry and neuroenergetics, and for investigating neurological disorders. However, it remains a challenge to achieve superior MRI/MRS detection sensitivity, spatial and temporal imaging resolutions adequate for addressing fundamental and challenging neuroscience questions even with the most advanced technology. The prevailing paradigms for improving MRI/MRS performance largely invoke increasing the magnetic field strength, which may have reached practically achievable limits for human studies due to many technological and safety (i.e., high specific absorption rate (SAR)) concerns, and increasing the receiver channel count which is also ultimately limited due to noise characteristics of coils of decreasing size. To alleviate these major limitations, this R24 proposal relies on the interdisciplinary research efforts and expertise of leading experts across two institutions to pioneer an entirely innovative engineering solution that uses the ultra-high dielectric constant (uHDC) material incorporated with ultrahigh-field MRI/MRS techniques for synergistically increase signal-to-noise ratio and concurrently reduce RF power demand, and for achieving unprecedented improvements in spatial/temporal resolution over the current state-of-the-art MR technologies. We will develop and optimize prototypes of uHDC material for human brain studies using 7 Tesla (T) and 10.5T whole-body human scanners. Moreover, we will exploit and assess the new utility and capability of the innovative uHDC-MR technology for cutting-edge neuroscience research. One pilot study is the functional mapping of neural circuits and resting-state connectivity at the level of columns and cortical layers in the human visual cortex with ultrahigh spatial resolution 1H MRI at 7T, complemented with anatomical connectivity derived from diffusion weighted images for tractography. The other one is to combine the uHDC technique with newly developed in vivo 31P and 17O MRS techniques for noninvasively and reliably imaging the cerebral metabolic rates of oxygen consumption and ATP, cerebral blood flow, oxygen extraction fraction and nicotinamide adenine dinucleotide (NAD) redox state in the human brain at resting and activated states. The proposed research will shift the current paradigm of neuroimaging development towards an efficient, cost-effective engineering solution that will attain multiplicative gains from uHDC and ultrahigh fields, and lead to next generation o MRI/MRS technology and instrument. Such advancement will accelerate human brain imaging and neuroscience research beyond what can be achieved through existing technology, promote new research directions, and transform our understanding regarding the human brain function and dysfunction.

 描述（由适用提供）：磁共振（MR）成像（MRI）和体内MR光谱法（MRS）技术已成为用于成像大脑结构，功能，连通性，神经化学和神经化学和研究神经学疾病的必不可少的工具。但是，达到卓越的MRI/MRS检测灵敏度，空间和临时成像决议仍然是一个挑战，即使使用最先进的技术，也足以解决基本和挑战性的神经科学问题。改善MRI/MRS性能的主要范例在很大程度上提高了磁场强度，由于许多技术和安全性（即高特定的滥用率（SAR））关注，实际上可能已经成功地限制了人类研究的限制，并且增加了接收器频道数量，这也增加了由于大小减小的噪声特征而最终受到了限制。 To alleviate these major limitations, this R24 proposal relies on the interdisciplinary research effort and expertise of leading experts across two institutions to pioneer an entirely innovative engineering solution that uses the ultra-high dieelectric constant (uHDC) material incorporated with ultra-high-field MRI/MRS techniques for synergistically increasing signal-to-noise ratio and concurrently reduce RF power demand, and for achieving空间/时间分辨率的前所未有的改进比当前的最新MR技术。我们将使用7 Tesla（T）和10.5T全身人类扫描仪开发并优化人脑研究的UHDC材料的原型。此外，我们将探索和评估创新的UHDC-MR技术在尖端神经科学研究中的新实用性和能力。一项初步研究是在人类视觉皮层的柱和皮质层的静止状态连接的功能映射，并在7T时具有超高空间分辨率1H MRI，并以从扩散加权图像从扩散加权图像中获得的解剖连通性完成。 The other one is to combine the uHDC technique with newly developed in vivo 31P and 17O MRS techniques for noninvasively and reliably imaging the cerebral metabolic rates of oxygen consumption and ATP, cerebral blood flow, oxygen extraction Fraction and nicotinamide adenine dinucleotide (NAD) redox state in the human brain at resting and activated states.拟议的研究将把神经影像发展的当前范式转移到有效，具有成本效益的工程解决方案上，该解决方案将获得UHDC和Ultrahigh Fields的乘法增长，并导致下一代ORI/MRI/MRS技术和工具。这种进步将加速人脑成像和神经科学研究，超出现有技术可以实现的目标，促进新的研究方向，并改变我们对人脑功能和功能障碍的理解。