A Hard and Clear, Estrogen-Free Replacement for Bisphenol-A Based Polycarbonates

一种坚硬、透明、不含雌激素的双酚 A 基聚碳酸酯替代品

• 批准号: 8723823
• 负责人: Yantian Wang
• 金额: $ 47.85万
• 依托单位: PLASTIPURE, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723823
• 关键词: Acids; Adolescent; Adverse effects; Advertising; Aggressive behavior; Attention; Behavioral; Beverages; Biological Assay; Brain; Characteristics; Chemicals; Cognitive; Complex Mixtures; Data; Development; Disease; Dose; Drug Formulations; Emotions; Endocrine Disruptors; Estrogens; Exhibits; Exposure to; Family; Food; Food Packaging; Freezing; Functional disorder; Glycols; Grant; Health; Heat Stress Disorders; Human; Infant; Ingestion; Injection of therapeutic agent; Interagency Coordinating Committee on the Validation of Alternative Methods; Juice; Learning Disabilities; Legal patent; Link; MCF7 cell; Malignant Neoplasms; Mammals; Marketing; Measures; Mechanics; Methods; Molds; Motivation; Obesity; Oils; Ovarian; Oxygen; Paper; Pathology; Peer Review; Phase; Physiological Processes; Plant Resins; Plastics; Polyethylene Terephthalates; Polyethylenes; Polymers; Polypropylenes; Polystyrenes; Property; Puberty; Public Health; Publications; Publishing; Reporting; Resistance; Risk; Scientist; Sex Orientation; Small Business Innovation Research Grant; Sperm Count Procedure; Stress; Sunlight; Testing; Thick; Ultraviolet Rays; Water; base; bisphenol A; cancer type; chemical release; consumer product; estrogenic activity; fetal; flexibility; in vitro Assay; in vivo; meetings; microwave electromagnetic radiation; monomer; novel; oxidation; phthalates; physical process; polycarbonate; polycarbonate plastic; prevent; prostate enlargement; public health relevance; soft drink; xenoestrogen

DESCRIPTION (provided by applicant): Many peer-reviewed publications show that Bisphenol A (BPA)-based polycarbonate (PC) and all other commonly used hard and clear (HC) plastics (e.g., polyethylene terephthalate (PET), glycol-modified polyethylene terephthalate (PETG), and polystyrene (PS)) leach endocrine disrupting chemicals that most commonly exhibit estrogenic activity (EA). BPA is only one of many hundreds of chemicals having EA or anti- EA used to manufacture HC plastic products. Chemicals having EA or anti-EA have been reported to have significant adverse effects on many behavioral and physiological processes such as sperm counts, uterine and ovarian functions, aggressive behaviors, and some types of cancers. These adverse effects sometimes occur at very low (picomolar to nanomolar) concentrations, especially on fetal or developing mammals (including humans). PlastiPure's (PPi's) data show that no consumer products or packaging made from EA-free** HC plastic are currently commercially available, including those made from PC substitutes currently advertised as BPA-free or phthalate-free. In fact, BPA-free plastics often release chemicals having more EA than do plastics made using BPA (e.g., PC plastics), especially when exposed to sunlight or other UV wavelengths. In order to meet a commercial and health-related need for plastics free of EA and anti-EA (EA-free** plastics), PPi is submitting a Phase II SBIR grant to confirm that it has developed a set of EA-free** resins that directly substitute for PC, PET, PETG, and PS resins that have many advantageous characteristics in different combinations, e.g., HC, microwavable, resistant to UV light and moisture, acid resistant, cold-tolerant (including freezing), and suitable for making thick- or thin-layered plastics, some of which have an oxygen barrier. PPi proposes to confirm that plastic products manufactured from these EA-free** resins remain EA- free** before and after common-use stresses of heat, moisture, UV and microwave radiation. PPi will use two very sensitive, reproducible and accurate in vitro assays and an in vivo assay to confirm that no chemicals having detectable EA are released from these resins or plastic products before or after stressing. Collectively, the novel EA-free**, BPA-free, HC plastics to be developed on this Phase II grant would replace PET, PETG, and other HC beverage and food-contacting plastics in highest-volume current use that all release chemicals having EA**. Products produced from these resins represent the best commercial opportunity, and the greatest potential reduction in chemicals having EA** that are currently released from plastics and ingested by consumers world-wide.

描述（由申请人提供）：许多同行评审出版物表明，基于双酚 A (BPA) 的聚碳酸酯 (PC) 和所有其他常用的硬质透明 (HC) 塑料（例如聚对苯二甲酸乙二醇酯 (PET)、乙二醇改性聚乙烯）对苯二甲酸酯（PETG）和聚苯乙烯（PS））会浸出最常表现出雌激素活性（EA）的内分泌干扰化学物质。 BPA 只是用于制造 HC 塑料产品的数百种含有 EA 或抗 EA 的化学品之一。据报道，含有 EA 或抗 EA 的化学物质会对许多行为和生理过程产生显着的不利影响，例如精子计数、子宫和卵巢功能、攻击行为和某些类型的癌症。这些不利影响有时会在非常低的浓度（皮摩尔至纳摩尔）下发生，特别是对胎儿或发育中的哺乳动物（包括人类）。 PlastiPure (PPi) 的数据显示，目前市场上还没有由不含 EA** HC 塑料制成的消费品或包装上市，包括目前宣传为不含 BPA 或不含邻苯二甲酸盐的 PC 替代品制成的产品或包装。事实上，不含 BPA 的塑料通常比使用 BPA 制成的塑料（例如 PC 塑料）释放出更多 EA 的化学物质，特别是当暴露在阳光或其他紫外线波长下时。 为了满足对不含 EA 和抗 EA 的塑料（不含 EA** 塑料）的商业和健康相关需求，PPi 正在提交第二阶段 SBIR 拨款，以确认其已开发出一套不含 EA* 的塑料* 直接替代PC、PET、PETG和PS树脂的树脂，在不同的组合中具有许多有利的特性，例如HC、可微波、耐紫外线和防潮、耐酸、耐寒（包括冷冻）和适合用于制造厚层或薄层塑料，其中一些具有氧气阻隔层。 PPi 建议确认由这些不含 EA** 树脂制造的塑料产品在受到常见的热、湿气、紫外线和微波辐射应力之前和之后仍保持不含 EA**。 PPi 将使用两种非常灵敏、可重复且准确的体外测定和体内测定来确认在压力之前或之后这些树脂或塑料产品中没有释放出具有可检测到的 EA 的化学物质。 总的来说，本次第二阶段拨款将开发的新型不含 EA**、不含 BPA 的 HC 塑料将取代 PET、PETG 和其他目前用量最大的饮料和食品接触用 HC 塑料，这些塑料均释放化学物质EA**。由这些树脂生产的产品代表了最佳的商业机会，并且最大程度地减少了目前从塑料中释放并被全世界消费者摄入的含有 EA** 的化学品。