Magnetic Particle Imaging Angiography for Chronic Kidney Disease Patients

慢性肾病患者的磁粒子成像血管造影

• 批准号: 8665423
• 负责人: STEVEN M CONOLLY
• 金额: $ 37.2万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665423
• 关键词: Acceleration; American; Anemia; Angiography; Caliber; Chronic Kidney Failure; Computer software; Contrast Media; Custom; FDA approved; Fibrosis; Gadolinium; Human; Image; Injection of therapeutic agent; Intravenous; Iodine; Ionizing radiation; Kidney Diseases; Magnetic Resonance Imaging; Magnetism; Measures; Medical; Methods; Mus; Patients; Physiologic pulse; Relaxation; Renal function; Research; Resolution; Roentgen Rays; Scanning; Speed; Staging; Testing; Time; Tissues; Venous; X-Ray Computed Tomography; abdominal aorta; design; ferumoxtran; gadolinium oxide; high risk; imaging modality; improved; in vivo; innovation; instrument; iron oxide; mouse model; nanoparticle; novel; particle

DESCRIPTION (provided by applicant): We will develop hardware, software and novel contrast agents for a new angiographic imaging modality called Magnetic Particle Imaging, which is completely different from X-ray, CT and MRI. Currently available angiographic contrast agents (iodine for X-ray and gadolinium for MRI) are dangerous for Chronic Kidney Disease patients. Magnetic Particle Imaging offers excellent image quality and the contrast agents are completely safe for Chronic Kidney Disease patients. This research will remove the final obstacles to a major medical breakthrough for Chronic Kidney Disease patients.

描述（由申请人提供）：我们将为一种称为磁性粒子成像的新型血管造影成像方式开发硬件，软件和新颖的对比度，该模态与X射线，CT和MRI完全不同。目前可用的血管造影造影剂（X射线碘和MRI的Gadolinium）对于慢性肾脏病患者是危险的。磁性颗粒成像具有出色的图像质量，对比度对于慢性肾脏病患者来说是完全安全的。这项研究将消除慢性肾脏病患者的重大医学突破的最终障碍。

项目成果

Gram scale synthesis of magnetite nanoparticles optimized for single-core MPI tracers.

针对单核 MPI 示踪剂优化的克级磁铁矿纳米粒子合成。

• DOI: 10.1109/iwmpi.2015.7107016
• 发表时间: 2015
• 期刊: ... International Workshop on Magnetic Particle Imaging. International Workshop on Magnetic Particle Imaging
• 作者: Kemp,ScottJ;Ferguson,RMatthew;Khandhar,AmitP;Krishnan,KannanM
• 通讯作者: Krishnan,KannanM

Relaxation in x-space magnetic particle imaging.

• DOI: 10.1109/tmi.2012.2217979
• 发表时间: 2012-12
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Croft LR;Goodwill PW;Conolly SM
• 通讯作者: Conolly SM

A Convex Formulation for Magnetic Particle Imaging X-Space Reconstruction.

• DOI: 10.1371/journal.pone.0140137
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Konkle JJ;Goodwill PW;Hensley DW;Orendorff RD;Lustig M;Conolly SM
• 通讯作者: Conolly SM

In vivo multimodal magnetic particle imaging (MPI) with tailored magneto/optical contrast agents.

• DOI: 10.1016/j.biomaterials.2015.02.040
• 发表时间: 2015-06
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Arami, Hamed;Khandhar, Amit P.;Tomitaka, Asahi;Yu, Elaine;Goodwill, Patrick W.;Conolly, Steven M.;Krishnan, Kannan M.
• 通讯作者: Krishnan, Kannan M.

Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging.

• DOI: 10.1088/1361-6560/aa5f48
• 发表时间: 2017-05-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Keselman P;Yu EY;Zhou XY;Goodwill PW;Chandrasekharan P;Ferguson RM;Khandhar AP;Kemp SJ;Krishnan KM;Zheng B;Conolly SM
• 通讯作者: Conolly SM