A pocket-sized device for personal exposure level assessment

用于个人暴露水平评估的袖珍设备

• 批准号: 8658433
• 负责人: Erica Silvia Forzani
• 金额: $ 49.31万
• 依托单位: TF SENSORS, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-24 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658433
• 关键词: Address; Air; Air Pollutants; Benzene; Binding; Breathing; Calibration; Carcinogens; Cells; Cellular Phone; Chemical Exposure; Chemicals; Collaborations; Communication; Communities; Computer software; Cosmetics; Coupled; Data; Detection; Development; Devices; Digital Signal Processing; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiologist; Equipment; Feedback; Future; Gas Chromatography; Genetic Predisposition to Disease; Goals; Gold; Health Technology; Healthcare; Home environment; Household; Housing; Hybrids; Immune; Individual; Industrial Waste; Industry; Location; Mass Spectrum Analysis; Measures; Mechanics; Methods; Molecular; Monitor; Neighborhoods; Neuraxis; Occupational Safety; Performance; Phase; Polymers; Population Study; Prevention; Production; Protocols documentation; Quartz; Reference Standards; Reporting; Research; Resolution; Sampling; Scheme; Scientist; Specificity; Staging; System; Technology; Telephone; Test Result; Testing; Time; Toluene; Toxic Environmental Substances; Universities; Variant; Wireless Technology; Work; Xylene; abstracting; air sampling; base; commercialization; computerized data processing; cost; empowered; ethylbenzene; imprint; improved; innovation; miniaturize; new technology; novel; operation; prototype; remediation; sample collection; sensor; tool; toxicant; trafficking; transmission process; usability; user-friendly; volatile organic compound

DESCRIPTION (provided by applicant): A pocket-sized device for personal exposure level assessment! Abstract Detecting environmental toxicants is critical for better understanding of the relationship between chemical exposures and many diseases, and for more effective prevention of the related diseases. Due to large variations in the individuals' genetic susceptibility and environmental exposure level, an ideal detection tool must be miniaturized, affordable and personalized so that it can measure the toxicants in real time and within each individual's breathing zone. Except for a few selected analytes, the current approach is to collect air samples at a certain location and time, and transport the samples to a lab for detailed analysis using sophisticated but expensive and difficult-to-operate equipment, such as gas chromatography coupled with mass spectrometry. The goal of the present project is to address the above need by introducing a new sensor technology, focusing on harmful analytes, such as carcinogens, which are important but currently not covered by any of the existing portable devices. The sensor technology is based on an innovative hybrid principle that combines intelligent sampling and separation mechanisms with a sensitive microfabricated quartz tuning fork array and selective molecular imprinted polymer sensing materials to achieve high specificity and high sensitivity with a miniaturized device. The device is pocket-sized and contains a Bluetooth chip that communicates wirelessly with cell phones or other Bluetooth-enabled devices. The new technology will provide unprecedented high temporal and high spatial resolutions for personal environmental exposure monitoring, which will benefit a large environmental health research community, support ongoing and future large-scale population studies, and impact on industrial and occupational safety and environmental monitoring. The team will develop, build and test the device in phase I. They will validate it with established collaborations, including epidemiologists, industry hygienists, occupational safety professionals and environmental scientists, and prepare for production of the device in phase II.

描述（由申请人提供）：用于个人暴露水平评估的袖珍设备！抽象检测环境有毒物质对于更好地理解化学暴露与许多疾病之间的关系以及对相关疾病的更有效预防至关重要。由于个体的遗传敏感性和环境暴露水平的差异很大，因此必须将理想的检测工具进行微型，负担得起和个性化，以便它可以实时和每个人的呼吸区内测量有毒物质。除了一些选定的分析物外，当前的方法是收集 在特定位置和时间的空气样品，并将样品运送到实验室，以使用复杂但昂贵且难以操作的设备（例如气相色谱法）加上质谱法进行详细分析。本项目的目的是通过引入一种新的传感器技术来满足上述需求，该技术重点介绍了有害分析物，例如致癌物，这些技术很重要，但目前尚未被任何现有的便携式设备所覆盖。传感器技术基于创新的混合原理，该原理将智能采样和分离机制与敏感的微生物石英调谐叉阵列和选择性分子刻痕的聚合物传感材料相结合，以实现高特异性和高敏感性，并使用微型化设备获得高敏感性。该设备是袖珍尺寸的，并包含一个蓝牙芯片，该芯片与手机或其他支持蓝牙的设备无线通信。 这项新技术将为个人环境暴露监测提供前所未有的高时空和高空间分辨率，这将使大型的环境健康研究社区受益，支持正在进行的和未来的大型人群研究，并对工业和职业安全以及环境监测产生影响。该团队将在第1阶段开发，建造和测试设备。他们将通过既定的合作，包括流行病学家，行业卫生学家，职业安全专业人员和环境科学家进行验证，并准备在第二阶段生产该设备。