Geroscience Network

老年科学网络

基本信息

批准号：
8738561
负责人：
JAMES L. KIRKLAND
金额：
$ 23.25万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8738561
关键词：
Address Affect Age Aging Agreement Animal Model Animals Applications Grants Area Arkansas Arthritis Atherosclerosis Bilateral Biology of Aging Blindness Caloric Restriction Cells Chronic Disease Clinic Clinical Clinical Trials Clinical Trials Network Collaborations Consensus Dementia Development Diabetes Mellitus Disease Educational Curriculum Equipment and supply inventories European Event Faculty Funding Gene Mutation Geroscience Goals Grant Growth Hormone Receptor Health Health Care Costs Health Sciences Human Human Resources Individual Institutes Institution Intervention Invertebrates Joints Kidney Diseases Laboratories Life Link Longevity Longitudinal Studies Malignant Neoplasms Mammals Measurable Measurement Medicine Metabolic syndrome Michigan Minnesota Monoclonal Antibody R24 Morbidity - disease rate Mus Mutation Osteoporosis Paper Pathway interactions Policies Population Population Study Preparation Process Protocols documentation Publications Research Infrastructure Research Personnel Resources Risk Risk Factors Scientist Sirolimus Stem cells Stress Testing Texas Time Tissues Translating Translations United States Universities Washington Work age related base bench to bedside clinical application college cost design disability effective therapy forest frailty human subject innovation insight juvenile animal medical schools modifiable risk mouse model pre-clinical prevent programs senescence therapeutic target trait translational study working group

项目摘要

DESCRIPTION (provided by applicant): Chronic diseases are the leading cause of morbidity and the major driver of health costs in the US. Aging is the leading risk factor for nearly all majr chronic diseases. Recent insights support the possibility that aging may be a modifiable risk factor. We hypothesize that by targeting fundamental mechanisms of aging, clinical interventions can be envisaged that could delay or prevent age-related diseases and disabilities as a group, rather than one at a time. We propose the following Specific Aims. Aim 1. Establish a national interdisciplinary network of aging centers as the basis for a Geroscience Network to understand and exploit links between aging and genesis of chronic disease. Initial partners will include geriatricians and basic scientists from Mayo Clinic, Buck Institute, Barshop Institute, Albert Einstein College of Medicine, Stanford, Harvard, Johns Hopkins, and Wake Forest Universities, and the Universities of Washington, Arkansas, Minnesota, and Michigan. By planning and working in a coordinated way through the Geroscience Network, we intend to accelerate development and translation of effective treatments to delay or prevent age-related disabilities and diseases. Aim 2. Use retreats to initiate planning for strategies, translational paradigms, curricula, and other resources needed to test our hypothesis. To begin developing the strategies, personnel, and infrastructure necessary, we will delineate the strengths of each center, identify gaps and areas of overlap, and develop consensus about areas of focus. Aim 3. Use faculty exchanges to bring together working groups to complete white papers, publications, and grants based on strategies and translational paradigms initiated during the retreats, continue planning for clinical trials networks, and develop curricula for developing personnel needed for translation of interventions arising from the basic biology of aging into clinical applications. These innovative approaches will allow us to translate findings from bench to bedside more rapidly than possible by individual centers, laboratories, and groups of geriatricians.

描述（由申请人提供）：慢性疾病是美国发病率的主要原因，也是美国健康成本的主要驱动因素。衰老是几乎所有MAD慢性疾病的主要危险因素。最近的见解支持衰老可能是可修改的危险因素的可能性。我们假设，通过靶向衰老的基本机制，可以设想临床干预措施，可以延迟或预防与年龄相关的疾病和残疾，而不是一次。我们提出以下特定目标。目标1。建立一个国家跨学科的衰老中心网络，作为Geroscience网络了解和利用慢性病与起源之间的联系的基础。最初的合作伙伴将包括来自Mayo诊所，Buck Institute，Barshop Institute，Albert Einstein医学院，斯坦福大学，哈佛大学，约翰·霍普金斯大学和Wake Forest大学以及华盛顿，阿肯色州，明尼苏达州和密歇根大学的大学的老年医生和基础科学家。通过通过Geroscience网络进行计划和工作，我们打算加快开发和翻译有效的治疗方法，以延迟或预防与年龄有关的残疾和疾病。目标2。使用务虚会来启动计划策略，翻译范式，课程和其他资源来检验我们的假设所需的资源。为了开始制定必要的策略，人员和基础设施，我们将描述每个中心的优势，确定重叠的差距和领域，并就重点领域建立共识。目标3。使用教师交流将工作组汇集在一起，以根据撤退期间发起的策略和翻译范例来完成白皮书，出版物和赠款，继续计划临床试验网络的计划，并开发用于转化的发展人员的课程，用于翻译由临床应用中的基本生物学生物学引起的干预措施。这些创新的方法将使我们能够比各个中心，实验室和老年医生群体更快地将发现从长凳转换为床边。