Characterization and Treatment of Sensory Intolerance in Childhood

儿童期感觉不耐受的特征和治疗

• 批准号: 8308123
• 负责人: Christine A Conelea
• 金额: $ 5.14万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308123
• 关键词: Address; Adult; Anxiety; Attention deficit hyperactivity disorder; Auditory; Autistic Disorder; Behavioral; Categories; Characteristics; Child; Childhood; Chronic; Clinic; Clinical; Data; Development; Developmental Therapeutics Program; Diagnosis; Diagnostic; Dimensions; Disease; Distress; Emotional; Epidemiology; Esthesia; Family Leave; Funding; Future; Gilles de la Tourette syndrome; Goals; Grant; High Prevalence; Impairment; Intervention; Life; Maintenance; Manuscripts; Medicaid; Mental disorders; Mentorship; National Institute of Child Health and Human Development; National Research Service Awards; Obsessive-Compulsive Disorder; Preparation; Prevalence; Primary Health Care; Psychopathology; Recruitment Activity; Research; Research Personnel; Research Technics; Research Training; Sampling; School-Age Population; Sensory; Staging; Stimulus; Structure; Symptoms; Tactile; Testing; Time; Training; Writing; base; career; cost; design; experience; functional disability; novel; psychologic; research and development; response; sensory integration; sensory stimulus; skills; social; statistics; theories; therapy development

DESCRIPTION (provided by applicant): This F32 National Research Service Award is designed to help the PI achieve her long-term career goal of becoming an independent investigator with lines of research focused on understanding the phenomenology and treatment of obsessive-compulsive spectrum disorders. Consistent with this goal, the proposed study will focus on extending the PI's research to the characterization and treatment of sensory intolerance (SI) in childhood. SI is an exaggerated, intense, and/or prolonged behavioral response toward certain sensations, such as tactile or auditory input. SI is a chronic condition associated with significant distress and functional impairment that may set the stage for the development of psychopathology later in life. Despite the high prevalence rate of SI, there are large gaps in the understanding of SI phenomenology and treatment that could be addressed by psychiatric research. Although SI is thought to cut across current diagnostic categories, little is known about the relationship of SI to other psychiatric disorders and symptom dimensions, information that is critical for future treatment development. In addition, there is a lack of available empirically- based treatment for SI. Thus, the overall aims of the current study are to 1) recruit 46 children from primary care clinics with SI complaints and conduct a comprehensive, clinician-administered assessment to better characterize and define SI and 2) pilot-test an exposure-based treatment in six children with primary SI symptoms using a multiple baseline design. The long term goal of the proposed study is designed to generate preliminary data necessary to begin a line of research focused on a) understanding the phenomenology, development, and maintenance of SI and b) developing an empirically supported intervention for SI. The highly structured training plan in the current application is ideally suited to allow the I to conduct the proposed research plan and to move towards her long-term career goals. The PI will receive training in 1) assessment, characterization, and clinical presentation of SI, 2) treatment development research techniques, 3) exposure-based therapy, 4) advanced statistics, and 5) manuscript preparation and grant writing skills. Training will be guided by an expert mentorship team with expertise in SI, exposure therapy, developmental psychopathology, and treatment development. Therefore, the proposed training and research plans will provide the PI with experiences necessary to accomplish her ultimate goal of becoming an independent investigator. PUBLIC HEALTH RELEVANCE: Sensory Intolerance (SI) is a chronic condition associated with significant distress and impairment that may set the stage for the development of psychopathology later in life. Despite the high prevalence rate of SI, there are large gaps in the understanding of SI characteristics and treatment that could be addressed by psychiatric research. The current study proposes to examine the relationship of SI to other psychiatric disorders and to pilot-test a novel psychological treatment for SI.

描述（由申请人提供）：该 F32 国家研究服务奖旨在帮助 PI 实现其长期职业目标，即成为一名独立研究者，其研究重点是了解强迫谱系障碍的现象学和治疗。与这一目标一致，拟议的研究将侧重于将 PI 的研究扩展到儿童感觉不耐受 (SI) 的表征和治疗。 SI 是对某些感觉（例如触觉或听觉输入）的夸张、强烈和/或长时间的行为反应。 SI 是一种与严重痛苦和功能障碍相关的慢性疾病，可能为以后生活中精神病理学的发展奠定基础。尽管 SI 的患病率很高，但对 SI 现象学和治疗的理解仍存在很大差距，可以通过精神病学研究来解决。尽管 SI 被认为可以跨越当前的诊断类别，但几乎没有 了解 SI 与其他精神疾病和症状维度的关系，这些信息对于未来的治疗开发至关重要。此外，缺乏可用的基于经验的 SI 治疗方法。因此，本研究的总体目标是 1) 从初级保健诊所招募 46 名有 SI 投诉的儿童，并进行临床医生管理的全面评估，以更好地描述和定义 SI；2) 在使用多基线设计对 6 名患有主要 SI 症状的儿童进行了研究。拟议研究的长期目标旨在生成开始一系列研究所需的初步数据，重点是：a）了解 SI 的现象学、发展和维护；b）开发基于经验的 SI 干预措施。 当前申请中的高度结构化的培训计划非常适合让我执行拟议的研究计划并朝着她的长期职业目标迈进。 PI 将接受以下方面的培训：1) SI 的评估、表征和临床演示，2) 治疗开发研究技术，3) 基于暴露的治疗，4) 高级统计，以及 5) 稿件准备和资助写作技能。培训将由具有 SI、暴露疗法、发展精神病理学和治疗开发方面专业知识的专家指导团队指导。因此，拟议的培训和研究计划将为 PI 提供实现其成为独立研究者的最终目标所需的经验。 公共卫生相关性：感觉不耐受 (SI) 是一种与严重痛苦和损伤相关的慢性疾病，可能为以后生活中精神病理学的发展奠定基础。尽管 SI 的患病率很高，但对 SI 特征和治疗的理解仍存在很大差距，可以通过精神病学研究来解决。目前的研究旨在研究 SI 与其他精神疾病的关系，并初步测试 SI 的新型心理治疗方法。