Southern California Children's Enviromental Health Center (SC-CEHC)

南加州儿童环境健康中心 (SC-CEHC)

• 批准号: 8690059
• 负责人: ROB S MCCONNELL
• 金额: $ 73.83万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8690059
• 关键词: 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex- 2-enone; 5 year old; Address; Adipose tissue; Adult; Advisory Committees; Affect; Air Pollution; Area; Biopsy; Blood Glucose; Body mass index; Budgets; California; Carbon; Cardiovascular Diseases; Cell physiology; Cells; Child; Child health care; Childhood; Clinical; Clinical Research; Collaborations; Communication; Communities; Community Integration; Community Outreach; Community Participation; Complex Mixtures; Development; Diabetes Mellitus; Educational workshop; Effectiveness of Interventions; Ensure; Environment; Environmental Exposure; Environmental Health; Epidemiologic Studies; Evaluation; Event; Exposure to; Faculty; Fasting; Fatty acid glycerol esters; Fostering; Gene Expression; Generations; Goals; Growth; Health; Image; Inflammation; Inflammatory; Insulin Resistance; Intervention; Investigation; Knowledge; Lead; Leadership; Life; Life Expectancy; Life Style; Link; Lipids; Liver diseases; Measurement; Metabolic; Metabolic syndrome; Metabolism; Metal exposure; Metals; Morbidity - disease rate; National Institute of Environmental Health Sciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Particulate; Pathway interactions; Peer Review Grants; Phenotype; Play; Policies; Pregnancy; Prevalence; Prevention; Process; Property; Public Health; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Sampling; Science; Scientist; Specialist; Structure of beta Cell of islet; Time; Transition Elements; Translating; Translational Research; Translations; Triglycerides; Visceral; base; blood glucose regulation; career; career development; clinical decision-making; cohort; experience; in utero; innovation; meetings; mortality; mouse model; multidisciplinary; next generation; non-alcoholic fatty liver; novel; nutrition; obesity in children; obesity risk; outreach; outreach program; population based; programs; research study; sedentary; skills; symposium; trend

DESCRIPTION (provided by applicant) The primary goal of the Core is to provide an efficient infrastructure coordinating and facilitatin activities across the Center and to promote scientific integration and community engagement. Drs. Rob McConnell and Michael Goran will provide leadership to achieve these goals, bringing expertise in environmental health and childhood obesity/metabolic function, respectively. The goal of the Core is to ensure multidisciplinary interactions among basic, clinical, and public health scientists and community outreach faculty and staff to enhance a world-class research and outreach program in children's health. The Core will establish an Executive Committee of SC-CEHC investigators and the COTC Director to foster scientific interaction and coordinate internal/external activities. A quarterly meeting will be organized to present research challenges and progress in more detail and to explore opportunities for scientific interaction across the three Projects and the COTC. An External Advisory Committee will meet annually to review progress and to provide evaluation and advice. All meetings and workshops will be organized with Core support. Specific Aims are to: 1) Coordinate a program of research that integrates state-of-the-art exposure assessment with innovative health effects research to achieve rapid advances in understanding the impact of air pollution on childhood obesity and metabolic dysregulation. The Core mechanisms will facilitate maturing collaboration between two USC teams conducting research on 1) exposure assessment and health effects of air pollution in children and 2) childhood obesity and diabetes. An important resource is the rich institutional scientific environment including complementary centers and an administrative infrastructure that will be leveraged to co-sponsor seminars and workshops and build scientific synergy within and outside the Center. 2) Facilitate the translation/application of research findings to prevention, policy, and clinical decision making arenas and provide valuable information to communities, clinicians and policymakers. The Core will provide administrative support to community engagement activities and to the Pediatric Health Specialist to help identify scientific and outreach opportunities for enhancing translation of Center research findings. 3) Provide fiscal management and reporting and coordinate interactions with NIEHS and EPA. The Core will manage all aspects of the budget including subcontracts and will assist the research projects and COTC with purchasing and reimbursements. The Core will prepare all reports and coordinate with NIEHS and EPA. 4) Foster the career development program of junior investigators into independent contributors to pediatric environmental health research. The Core will coordinate a robust career development program to promote the progress of the faculty development investigator to research independence. The investigators will provide opportunities for mock peer review of grant applications, review of presentation skills, networking with other investigators within the USC research community and beyond. Career development activities have been part of the existing SCEHSC, a program which ranked highly in that center's external review. In addition, participation in COTC activities will be an opportunity to develop skills in non-technical presentations that will be a valuable career asset. 5) Make important contributions to national networks that foster communication, innovation, and research excellence in the area of children's environmental health. The Core, COTC and SC-CEHC leadership will participate in conference calls and the annual meetings of SC-CEHC directors. Opportunities for inter-Center collaboration will be sought. In addition, SC-CEHC investigators will participate in national conference calls including those of the NIEHS Programs in Environmental Public Health Network, and of other groups, to present the SC-CEHC's most recent research findings on air pollution, obesity and metabolic consequences.

描述（由申请人提供） 核心的主要目标是提供有效的基础设施协调和促进整个中心的活动，并促进科学融合和社区参与。博士。罗布·麦康奈尔（Rob McConnell）和迈克尔·戈兰（Michael Goran）将提供领导才能实现这些目标，分别带来环境健康和儿童肥胖/代谢功能的专业知识。核心的目的是确保基本，临床和公共卫生科学家以及社区外展教师和员工之间的多学科互动，以增强世界一流的儿童健康研究和外展计划。核心将成立一个SC-CEHC调查人员和COTC主管的执行委员会，以促进科学互动并协调内部/外部活动。将组织一次季度会议，以更详细地提出研究挑战和进展，并探索三个项目和COTC的科学互动机会。 外部咨询委员会将每年开会以审查进度并提供评估和建议。 所有会议和讲习班都将在核心支持下组织。具体目的是： 1）协调一项研究计划，该计划将最新的暴露评估与创新的健康效应研究整合在一起，以在理解空气污染对儿童肥胖和代谢失调的影响方面取得快速的进步。核心机制将促进对两个对儿童空气污染的暴露评估和健康影响的USC团队之间的成熟协作，以及2）儿童肥胖和糖尿病。一个重要的资源是丰富的机构科学环境，包括互补中心和行政基础设施，这些基础设施将被利用为共同赞助的研讨会和讲习班，并在中心内外建立科学协同作用。 2）促进研究结果的翻译/应用于预防，政策和临床决策领域，并为社区，临床医生和政策制定者提供宝贵的信息。核心将为社区参与活动和儿科健康专家提供行政支持，以帮助确定加强中心研究结果翻译的科学和外展机会。 3）提供财政管理和报告并协调与NIEHS和EPA的互动。核心将管理预算的各个方面，包括分包合同，并将协助研究项目和COTC进行购买和报销。核心将准备所有报告并与NIEHS和EPA进行协调。 4）培养初级研究人员的职业发展计划，为小儿环境健康研究的独立贡献者。核心将协调一项强大的职业发展计划，以促进教师发展研究者研究独立性的进步。调查人员将提供对赠款申请的模拟同行审查，演示技巧的审查，与USC研究社区及其他地区的其他调查人员进行联网的机会。职业发展活动已成为现有SCEHSC的一部分，该计划在该中心的外部审查中排名很高。此外，参与COTC活动将是一个在非技术演示中发展技能的机会，这将是宝贵的职业资产。 5）为促进儿童环境健康领域促进沟通，创新和研究卓越的国家网络做出重要贡献。核心，COTC和SC-CEHC领导层将参加电话会议和SC-CEHC董事的年度会议。将寻求中心间协作的机会。此外，SC-CEHC调查人员将参加全国性的电话会议，包括环境公共卫生网络中的NIEHS计划和其他团体的呼叫，以介绍SC-CEHC关于空气污染，肥胖和代谢后果的最新研究结果。