PREVENTION-CONTROL

预防控制

基本信息

批准号：
8616647
负责人：
AL MARCUS
金额：
$ 3.34万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8616647
关键词：
African American Animal Model Area Behavioral Behavioral Research Breast Cancer Risk Factor Cancer Burden Cancer Center Support Grant Cancer Control Cancer Survivor Cancer Survivorship Chemoprevention Child Clinical Trials Cognitive remediation Colon Carcinoma Colorado Colorectal Cancer Communities Consumption Counseling Development Diet and Nutrition Focus Groups Funding Goals Health Incidence Industry Instruction Laboratory Research Latina Latino Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Malignant neoplasm of urinary bladder Medical center Morbidity - disease rate Native Americans Nevus Outcome Paper Pediatric Hospitals Peer Review Physical activity Population Population Sciences Primary Prevention Printing Property Publications Publishing Recreation Research Schools Science Secondary Prevention Services Site Telephone Translational Research United States Department of Veterans Affairs Universities Wolves base cancer epidemiology cancer prevention childhood cancer survivor colorectal cancer screening dissemination research effective intervention fruits and vegetables grape seed extract health disparity malignant breast neoplasm member mortality oncology programs psychosocial silibinin smoking cessation sun protection survivorship tobacco control

项目摘要

PROJECT SUMMARY (See instructions): Members of the Cancer Prevention and Control Program (PC) conduct population sciences and chemoprevention research that has significant potential to reduce the cancer burden in Colorado, the Rocky Mountain Region and beyond. PC has three main focus groups: 1) behavioral research in primary and secondary prevention, 2) chemoprevention research, and 3) cancer outcomes and cancer survivorship research. During the current CCSG program members have made numerous contributions to the science of cancer prevention and control, including: 1) several large research clinical trials (RCTs) that have demonstrated the efficacy of tailored print materials to promote fruit and vegetable consumption, colorectal cancer screening and smoking cessation; 2) a large school-based program and a monumental effort that targeted the outdoor winter recreation industry that successfully promoted sun protection; 3) a robust program of laboratory research that has demonstrated the chemoprevention properties of silibinin in animal models for prostate, lung, colorectal, and bladder cancer, as well as grape seed extract for prostate and colon cancer; 4) a large multi-site RCT demonstrating the efficacy of telephone counseling on psychosocial outcomes among breast cancer survivors; 5) a large multi-site RCT that demonstrated the efficacy of a cognitive remediation program for young survivors of childhood cancer; 6) two of the most definitive programs of research in cancer epidemiology that have examined and identified risk factors for breast cancer among Latinas, and nevus development among young children in Colorado, and 7) numerous exemplars of translational science and dissemination research in the areas of sun protection, diet, nutrition and physical activity, tobacco control, colorectal cancer screening and chemoprevention research. PC includes 31 Full Members and 32 Associate Members drawn from 17 academic departments and schools within the University of Colorado Denver, University of Colorado Boulder, the Veterans Administration (Denver), Colorado State University, Denver Health Medical Center, The Children's Hospital (Denver) and Kaiser Permanente of Colorado. During the current CCSG, program members have published 594 peer-reviewed cancer-related papers, compared to 306 during the previous CCSG. 37% of these publications were collaborative, with 23% being interprogrammatic or both interprogrammatic and intraprogrammatic. Peer reviewed, cancer-related funding has also increased from $8.9M (2005) to $13.3M in 2010. This represents a per capita increase of 140% from $269K to over $640K per member.

项目摘要（参见说明）：癌症预防和控制计划 (PC) 的成员开展人口科学和化学预防研究，这些研究对于减少科罗拉多州、落基山脉地区及其他地区的癌症负担具有巨大潜力。 PC 有三个主要焦点组：1) 一级和二级预防的行为研究，2) 化学预防研究，3) 癌症结果和癌症生存研究。在当前的 CCSG 项目成员为科学做出了许多贡献癌症预防和控制，包括：1）多项大型研究临床试验（RCT）证明了定制印刷材料在促进水果和蔬菜消费、结直肠癌筛查和戒烟方面的功效； 2) 一项大型校本计划和一项针对户外冬季休闲产业的巨大努力，成功推广了防晒； 3) 一项强有力的实验室研究计划，证明了水飞蓟宾在动物体内的化学预防特性前列腺癌、肺癌、结直肠癌和膀胱癌模型，以及前列腺癌和结肠癌的葡萄籽提取物； 4) 一项大型多中心随机对照试验，证明电话咨询对乳腺癌幸存者心理社会结果的功效； 5) 一项大型多中心随机对照试验，证明了认知矫正计划对儿童癌症年轻幸存者的有效性； 6) 两个最权威的癌症流行病学研究项目已检查并确定了乳腺癌的危险因素拉丁裔中的痣发展以及科罗拉多州幼儿中的痣发展，以及 7) 在防晒、饮食、营养和身体活动、烟草控制、结直肠癌筛查和化学预防研究领域的众多转化科学和传播研究范例。 PC 包括 31 名正式会员和 32 名准会员，来自科罗拉多大学丹佛分校、科罗拉多大学博尔德分校、退伍军人管理局（丹佛）、科罗拉多州立大学、丹佛健康医疗中心、儿童医院（丹佛）和科罗拉多州凯撒医疗机构。在当前的 CCSG 期间，项目成员发表了 594 篇经过同行评审的癌症相关论文，而上一届 CCSG 期间为 306 篇。其中 37% 的出版物是协作的，23% 是跨项目的或既是跨项目又是项目内的。经过同行评审，与癌症相关的资金也从 890 万美元（2005 年）增加到 2010 年的 1,330 万美元。这意味着人均增长了 140%，从每位会员的 26.9 万美元增加到超过 64 万美元。