A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)

将饮食引起的肥胖与癌症联系起来的果蝇模型 (PQ 1)

基本信息

批准号：
8383704
负责人：
Ross Leigh Cagan
金额：
$ 35.17万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8383704
关键词：
Address Animal Genetics Animals Biological Assay Cancer Model Carbohydrates Chemicals Collection Colon Carcinoma Complex Data Development Diet Dietary Sucrose Dietary Sugars Drosophila genus Epidemiologic Studies FDA approved Fatty acid glycerol esters Functional disorder Genes Genetic Screening Goals Hyperglycemia In Situ Insulin Resistance Laboratories Libraries Link Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of pancreas Mediating Metabolic Microarray Analysis Modeling Molecular Molecular Profiling Mutation Neoplasm Metastasis Obesity Palate Pathway interactions Pharmaceutical Preparations Property Risk Robotics Screening procedure Severities Sucrose System TP53 gene Testing Therapeutic Tissues Tumor Suppressor Genes base cancer risk cancer type experience feeding fly inhibitor/antagonist response tumor tumor progression tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): Epidemiological studies have demonstrated that increased cancer risk is associated with obesity, but the underlying mechanism remains poorly understood. We have recently developed a Drosophila model of obesity; raising Drosophila on a diet high in carbohydrates led to metabolic dysfunction including hyperglycemia, insulin-resistance and accumulation of fat. Feeding a high dietary sucrose to Ras/Src co- activated Drosophila cancer model developed aggressive tumor with emergent metastasis in a diet-dependent manner. The goal of this Application is to further utilize Drosophila as a useful in situ model to explore mechanistic link between diet-induced obesity and tumor progression. PUBLIC HEALTH RELEVANCE: Epidemiological studies have long shown that obesity and other metabolic dysfunctions increase the risk and severity of tumor progression. In this Application we use fruit flies to explore the mechanisms by which high dietary sugar enhances tumorigenesis.

描述（由申请人提供）：流行病学研究表明，癌症风险增加与肥胖有关，但其潜在机制仍知之甚少。我们最近开发了果蝇肥胖模型；以高碳水化合物饮食饲养果蝇会导致代谢功能障碍，包括高血糖、胰岛素抵抗和脂肪堆积。给 Ras/Src 共激活的果蝇癌症模型喂食高膳食蔗糖，会形成侵袭性肿瘤，并以饮食依赖性方式出现转移。本申请的目标是进一步利用果蝇作为有用的原位模型探索饮食引起的肥胖与肿瘤进展之间的机制联系。公共卫生相关性：流行病学研究长期以来表明，肥胖和其他代谢功能障碍会增加肿瘤进展的风险和严重程度。在此应用中，我们使用果蝇来探索高膳食糖促进肿瘤发生的机制。