South Carolina Collaborative Alliance for Stroke Trials (SC-CoAST)

南卡罗来纳州卒中试验合作联盟 (SC-CoAST)

• 批准号: 8739562
• 负责人: Edward C Jauch
• 金额: $ 33.18万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-25 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739562
• 关键词: Academic Medical Centers; Acute; Address; Adult; African American; Ally; Biological Markers; Caring; Cause of Death; Childhood stroke; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Commit; Communities; Community Hospitals; Contracts; Country; Development; Discipline; Disease; Drops; Education; Ensure; Environment; Epidemic; Etiology; Evaluation; Fibrinolysis; Goals; Health Hazards; Health Personnel; Health Services Accessibility; Health system; Healthcare; Healthcare Systems; Heart; Image; Incidence; Individual; Interdisciplinary Study; Intervention; Intervention Studies; Ischemic Stroke; Leadership; Medical; Mentors; Mission; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurosciences; Patients; Perception; Population; Population Heterogeneity; Positioning Attribute; Prevention; Principal Investigator; Recovery; Recruitment Activity; Rehabilitation therapy; Reperfusion Therapy; Research; Research Infrastructure; Research Personnel; Running; Rural; Science; Scientist; Secondary Prevention; South Carolina; Staging; Stroke; System; Techniques; Technology; Therapeutic; Thinking; Time; Training; United States; Universities; Work; acute stroke; base; bioimaging; care systems; career; career development; clinical care; clinical infrastructure; data management; experience; high risk; improved; innovation; member; mortality; next generation; novel; outreach; preclinical study; public health relevance; rehabilitation strategy; response; socioeconomics; stroke education; stroke recovery; stroke therapy; tertiary care

DESCRIPTION (provided by applicant): Despite dropping to the fourth leading cause of death in the United States, the incidence of stroke continues to rise and the individual and societal impact continues to grow. The burden of stroke disproportionately impacts lower socioeconomic populations and is particularly concentrated in the Southeast United States - the so-called Stroke Belt. Reaching these populations for stroke education, prevention, acute treatment, rehabilitation, and in particular in engagement in clinical research, remains a challenge. Developing clinical and research infrastructures to engage these populations are critical to change the disproportionate stroke burden. The perception of stroke as a treatable disease and the systems of care developed to manage stroke have made major advances from a time when stroke was viewed nihilistically. The development of fibrinolysis for stroke dramatically changed the paradigm for acute stroke treatment - for the first time acute ischemic stroke could be "reversed". This development provided promise and enthusiasm for developing further preventative, acute interventions, and novel rehabilitation strategies, but to date, clinical trial of potential therapies have yet to produce a definitive new reperfusion strategy. Conducting multicenter clinical trials of stroke therapies and interventions often must be performed within a highly contracted time scale, requiring innovative thinking and redesign of many aspects of the science of clinical trials. To be effective and fast, the NINDS Stroke Trials Network will require spectrum of clinicians, researchers, and allied healthcare providers to create a regional infrastructure that will effectively and efficiently recruit patients into trials across the broad spectrum of stroke etiologies and time frames. In this application the investigators propose to become a Regional Coordinating Center (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The South Carolina Collaborative Alliance for Stroke Irials (SC-CoAST) Network is a unique collaboration between 3 academic medical centers, the Medical University of South Carolina, the University of South Carolina, and the Greenville Heath System, situated in the heart of the Stroke Belt. The overall goals of the SC-CoAST Network are: 1) to expand the SC state-wide stroke organization to improve stroke care and research; 2) to leverage the SC-CoAST collaboration to become a leading center within the STN; 3) to utilize SC-CoAST preclinical researchers in developing potential interventions for study within the STN; and 4) to engage SC-CoAST senior leaders in identifying, mentoring, and training young clinician-scientists at this formative stage of their career development.

描述（由申请人提供）：尽管中风已降至美国第四大死因，但中风的发病率仍在持续上升，对个人和社会的影响也在持续加大。中风的负担不成比例地影响社会经济地位较低的人群，特别集中在美国东南部 - 所谓的中风带。对这些人群进行中风教育、预防、急性治疗、康复，特别是参与临床研究，仍然是一个挑战。开发临床和研究基础设施来吸引这些人群对于改变不成比例的中风负担至关重要。 从中风被虚无主义地看待的时代起，中风作为一种可治疗疾病的观念以及为管理中风而开发的护理系统已经取得了重大进步。中风纤溶治疗的发展极大地改变了急性中风治疗的范式——急性缺血性中风第一次可以“逆转”。这一进展为开发进一步的预防性急性干预措施和新颖的康复策略提供了希望和热情，但迄今为止，潜在疗法的临床试验尚未产生明确的新再灌注策略。进行中风治疗和干预的多中心临床试验通常必须在高度缩短的时间范围内进行，需要创新思维并重新设计临床试验科学的许多方面。为了有效和快速，NINDS 中风试验网络将需要一系列临床医生、研究人员和联合医疗保健提供者创建一个区域基础设施，以有效和高效地招募患者参与广泛的中风病因和时间范围的试验。 在此申请中，研究人员提议成为 NINDS 卒中试验网络 (RFA-NS-13-011) 中的区域协调中心 (RCC)。南卡罗来纳州中风协作联盟 (SC-CoAST) 网络是 3 个学术医疗中心（南卡罗来纳医科大学、南卡罗来纳大学和位于中风中心的格林维尔卫生系统）之间的独特合作腰带。 SC-CoAST 网络的总体目标是： 1) 扩大 SC 全州卒中组织，以改善卒中护理和研究； 2) 利用 SC-CoAST 合作成为 STN 内的领先中心； 3) 利用 SC-CoAST 临床前研究人员开发潜在的干预措施以供 STN 内的研究； 4) 让 SC-CoAST 高级领导参与识别、指导和培训处于职业发展形成阶段的年轻临床医生科学家。