Spotrias Network Sample Respository Core

Spotrias 网络示例存储库核心

• 批准号: 7870275
• 负责人: Edward C Jauch
• 金额: $ 6.73万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7870275
• 关键词: Aliquot; Biological; Blood specimen; Cells; Clinical Trials; Collection; Communities; Databases; Ensure; Genetic; Genetic Materials; Goals; International; Link; National Institute of Neurological Disorders and Stroke; Outcome; Patients; Plasma; Population; Process; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Site; Societies; Stroke; Whole Blood; acute stroke; repository; time interval

The SPOTRIAS Network Sample Repository (SNSR) is a unique repository resource for the SPOTRIAS network, which proposes to collect, preserve, and make available unique biologic samples from patients with acute stroke. The specific goals of the SNSR include: 1) Supervise and facilitate the collection, processing, and distributed storage of plasma samples from patients with acute stroke. Through the well established clinical trials and community core infrastructure within each site in the SPOTRIAS network a large population of stroke patients will be available for recruitment into the sample repository project. Plasma samples will be collected at several time intervals and aliquots sent to the SPOTRIAS SNSR. 2) Coordinate the collection of unique genetic samples from patients with acute stroke for contribution to the NINDS sponsored Coriell Cell Repository through the well established clinical trials and community core infrastructure within each site in the SPOTRIAS network a large population of stroke patients will be available for recruitment. Genetic materials collected through whole blood samples will be sent to the Coriell Cell Repository and linked to the SNSR samples through the KAI database. 3) Provide general oversight and management of the SNSR ensuring optimal storage of the plasma samples to facilitate research by SPOTRIAS and NINDS investigators in stroke research. Utilizing best practices for repositories as defined by the International Society for Biological and Environmental Repositories (ISBER) plasma samples will be available, upon approval of the SPOTRIAS SNSR Steering Committee, for use in stroke research.

SPOTRIAS 网络示例存储库 (SNSR) 是 SPOTRIAS 的独特存储库资源 该网络旨在收集、保存和提供来自患有以下疾病的患者的独特生物样本 急性中风。 SNSR 的具体目标包括： 1) 监督并促进血浆样本的采集、处理和分布式储存 急性中风患者。通过完善的临床试验和社区核心基础设施 在 SPOTRIAS 网络的每个站点内，将为大量中风患者提供治疗 招募到样本存储库项目。将在几个时间间隔收集血浆样本 并将等分试样发送至 SPOTRIAS SNSR。 2) 协调从急性中风患者身上收集独特的基因样本，为研究做出贡献 NINDS 通过完善的临床试验和社区核心赞助了 Coriell 细胞存储库 SPOTRIAS 网络中每个站点内的基础设施将大量中风患者 可供招聘。通过全血样本收集的遗传物质将被送往 Coriell Cell Repository 并通过 KAI 数据库链接到 SNSR 样本。 3) 提供 SNSR 的总体监督和管理，确保血浆的最佳存储 样本以促进 SPOTRIAS 和 NINDS 研究人员在中风研究中的研究。充分利用 国际生物与环境学会定义的储存库实践 经 SPOTRIAS SNSR 指导委员会批准后，将提供储存库 (ISBER) 血浆样本 委员会，用于中风研究。