Administrative Core
行政核心
基本信息
- 批准号:8934412
- 负责人:
- 金额:$ 10.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-01 至 2016-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcademiaAdministratorAdverse effectsAttenuatedBackBiologyBiomedical ResearchBiotechnologyBudgetsCodeCollaborationsCommunitiesCompanionsComputer softwareDataData SetData SourcesData Storage and RetrievalDatabasesDepositionDevelopmentDiseaseDrug TargetingEnsureEnvironmentEventFacultyFamilyFibrosisFoundationsGene ProteinsGene TargetingGenesGenomeGoalsIndividualIndustryIndustry CollaboratorsInformation Resources ManagementInstitutionInternetInvestigationInvestmentsIon ChannelKidneyKnowledgeLaboratoriesLeadLeadershipLinkLiteratureMaintenanceMolecular and Cellular BiologyNuclear ReceptorsOnline SystemsPatientsPersonsPharmaceutical PreparationsPositioning AttributeProceduresProductionProductivityProgress ReportsProtein KinaseRecoveryRegulationReportingResearchResearch PersonnelResourcesRunningScheduleScienceServicesSourceSource CodeSystemTertiary Protein StructureTimeTrainingTraining ActivityUnited States National Institutes of HealthValidationabstractingbasecareercomputer infrastructuredata managementdisease phenotypeexperiencegenome-wideinnovationinterestmeetingsmembernovelopen sourceprofessorprogramsrepositorysoftware developmentsoftware systemstechnology development
项目摘要
The Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG) at Mount Sinai will assemble, organize and visualize data collected from the under-studied druggable genome from the four families: protein kinases, nuclear receptor, ion channels and GPCRs. The KMC-IDG will also attempt linking such under-studied druggable targets for their potential applications in various diseases. To achieve this we will assemble and abstract data from four domains: proteins/genes/targets, drugs/perturbagens, diseases/phenotypes/side-effects, and data from individual patients. Various pipe-lines and workflow will be established to connect clusters of patients from various diseases to under-studied druggable targets. The Ma'ayan and Dudley Labs are well positioned to carry out successfully this project based on their prior track record of productivity, foundation of source code and data that is already collected and organized, and strong existing user base that can be directed to the newly developed portal. In addition, both labs have a strong track record of collaborations including the computational identification and experimental validation of at least one under-studied protein kinase as a potential important target for attenuating kidney fibrosis. One unique and innovative research component of this project is an investigation into the sources of the literature and experimental biases that exist in the molecular and cellular biology research domains.
位于西奈山的阐明药物基因组知识管理中心 (KMC-IDG) 将收集、组织和可视化从四个家族的尚未研究的药物基因组中收集的数据:蛋白激酶、核受体、离子通道和 GPCR。 KMC-IDG 还将尝试将这些尚未充分研究的药物靶标联系起来,以了解它们在各种疾病中的潜在应用。为了实现这一目标,我们将收集和提取来自四个领域的数据:蛋白质/基因/靶标、药物/扰动物、疾病/表型/副作用以及来自个体患者的数据。将建立各种管道和工作流程,将各种疾病的患者群与尚未充分研究的药物靶标连接起来。 Ma'ayan 和 Dudley 实验室基于之前的生产力记录、已收集和组织的源代码和数据基础,以及可引导至新产品的强大现有用户群,处于有利地位,能够成功实施该项目。开发的门户网站。此外,两个实验室都拥有良好的合作记录,包括对至少一种尚未研究的蛋白激酶作为减轻肾纤维化的潜在重要靶点进行计算鉴定和实验验证。该项目的一个独特且创新的研究组成部分是对分子和细胞生物学研究领域中存在的文献来源和实验偏差的调查。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joel Thomas Dudley其他文献
Joel Thomas Dudley的其他文献
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{{ truncateString('Joel Thomas Dudley', 18)}}的其他基金
Integrated understanding of complex viral network biology in Alzheimer's Disease
对阿尔茨海默病复杂病毒网络生物学的综合理解
- 批准号:
9557996 - 财政年份:2017
- 资助金额:
$ 10.01万 - 项目类别:
Pre-clinical Testing of a Novel Therapeutic for Nonalcoholic Steatohepatitis
非酒精性脂肪性肝炎新疗法的临床前测试
- 批准号:
9386379 - 财政年份:2017
- 资助金额:
$ 10.01万 - 项目类别:
Mount Sinai's Knowledge Management Center for Illuminating the Druggable Genome
西奈山阐明可药物基因组的知识管理中心
- 批准号:
9558160 - 财政年份:2014
- 资助金额:
$ 10.01万 - 项目类别:
Mount Sinai's Knowledge Management Center for Illuminating the Druggable Genome
西奈山阐明可药物基因组的知识管理中心
- 批准号:
8785466 - 财政年份:2014
- 资助金额:
$ 10.01万 - 项目类别:
Network Based Predictive Drug Discovery for Alzheimer's Disease
基于网络的阿尔茨海默病预测药物发现
- 批准号:
8849718 - 财政年份:2014
- 资助金额:
$ 10.01万 - 项目类别:
Mount Sinai's Knowledge Management Center for Illuminating the Druggable Genome
西奈山阐明可药物基因组的知识管理中心
- 批准号:
9325632 - 财政年份:2014
- 资助金额:
$ 10.01万 - 项目类别:
Methods for Evolutionary Informed Network Analysis to Discover Disease Variation
用于发现疾病变异的进化知情网络分析方法
- 批准号:
8826738 - 财政年份:2013
- 资助金额:
$ 10.01万 - 项目类别:
Methods for Evolutionary Informed Network Analysis to Discover Disease Variation
用于发现疾病变异的进化知情网络分析方法
- 批准号:
8482670 - 财政年份:2013
- 资助金额:
$ 10.01万 - 项目类别: