Cardiovascular Risk Perception and Wellness Perspectives in HIV-infected Adults

HIV 感染者的心血管风险认知和健康观点

• 批准号: 8846418
• 负责人: Patricia Ann Cioe
• 金额: $ 13.23万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8846418
• 关键词: Accounting; Acute myocardial infarction; Address; Adopted; Adoption; Adult; Aerobic; Affect; Age; American Heart Association; Award; Awareness; Behavior; Behavior Therapy; Cardiovascular Diseases; Chronic; Chronic Disease; Clinical Trials; Comorbidity; Development; Diabetes Mellitus; Diet; Dyslipidemias; Effectiveness; Elements; Exercise; Feedback; Future; General Population; Goals; HIV; Health; Health behavior; Heart; High Prevalence; Hyperlipidemia; Hypertension; Individual; Inflammation; Intervention; Interview; Knowledge; Lead; Life; Link; Literature; Longevity; Manuals; Mentored Patient-Oriented Research Career Development Award; Mentors; Metabolic; Modeling; Morbidity - disease rate; Motivation; Nurses; Obesity; Participant; Patients; Perception; Persons; Phase; Physical activity; Pilot Projects; Primary Prevention; Process; Protocols documentation; Qualitative Methods; Qualitative Research; Randomized; Randomized Clinical Trials; Recommendation; Relative (related person); Research; Research Methodology; Research Training; Risk; Risk Assessment; Risk Factors; Role; Science; Scientist; Smoking; Structure; Techniques; Testing; Treatment Protocols; Work; aging population; arm; base; behavior change; brief advice; cardiovascular disorder risk; cardiovascular risk factor; career; experience; good diet; health belief; improved; innovation; mortality; motivated behavior; motivational enhancement therapy; phosphoribosylanthranilate isomerase; preference; public health relevance; risk perception; satisfaction; skills; theories; therapy development

DESCRIPTION (provided by applicant): This three-year K23 research and training award will enable the PI to acquire the knowledge and skills needed to become an independent nurse scientist, with the long-term goal of conducting research to develop and implement innovative interventions that reduce cardiovascular risk and promote wellness in HIV-infected patients. Cardiovascular disease (CVD) has emerged as a major cause of morbidity and mortality (evidenced by a higher rate of acute myocardial infarction at younger ages) in persons living with HIV (PLWH) compared with uninfected individuals. PLWH have a higher prevalence of traditional CVD risk factors, as well as increased comorbidities, such as hypertension, diabetes, obesity, and hyperlipidemia. Given the role of CVD in HIV-infected patients' mortality, understanding CVD risk perception and risk factor knowledge, and developing tailored interventions is imperative. This project draws on the Health Belief Model to better understand how PLWH perceive their risk for CVD, and to develop a motivational interviewing (MI)-based intervention to improve not only CVD risk perception but also the adoption of health-promoting behaviors in PLWH. The specific aims of the study are to: 1) describe and explore perceptions of CVD risk and the likelihood, preferences, benefits, and barriers of adopting health-promoting behaviors; 2.a.) develop a treatment manual for an individually delivered CVD risk assessment and lifestyle modification management intervention, and, 2.b.) conduct a pilot study to test the feasibility and acceptability of the 2-session intervention. Phase 1 will include in-depth individul qualitative interviews with 30-40 PLWH. Phase 2.a. will include manual development, a pilot of the preliminary protocol with 8-10 PLWH, and manual revisions. Phase 2.b. will include a randomized 2-arm (intervention or brief advice) pilot clinical trial with 40 PLWH. The knowledge gained from this study will inform the future development of a full-scale randomized clinical trial to examine the effectiveness of a tailored intervention to improve CVD risk perception, improve adoption of heart-healthy behaviors, and reduce CVD risk in HIV-infected patients. The proposed K23 research will contribute a missing and fundamental element to our understanding and management of CVD risk in HIV-infected patients. The PI will work with experienced mentors to build expertise in: (1) qualitative research methods and analyses; and, (2) intervention development and pilot testing. This K23 proposal addresses a key priority in HIV treatment science and will fully prepare the PI for a research career as an HIV intervention scientist.

描述（由申请人提供）：这项为期三年的K23研究和培训奖将使PI能够获取成为独立护士科学家所需的知识和技能，其长期目标是进行研究以开发和实施创新的干预措施，以降低心血管风险并降低艾滋病毒感染患者的健康。与未感染的个体相比，患有HIV（PLWH）患者（PLWH）患者中，心血管疾病（CVD）已成为发病率和死亡率的主要原因（以更高的急性心肌梗死率证明了。 PLWH的传统CVD风险因素的患病率较高，并且合并症增加，例如高血压，糖尿病，肥胖和高脂血症。鉴于CVD在HIV感染患者的死亡率中的作用，了解CVD风险感知和风险因素知识以及制定量身定制的干预措施至关重要。该项目借鉴了健康信念模型，以更好地了解PLWH如何感知其CVD的风险，并开发基于动机的访谈（MI）干预措施，不仅改善了CVD风险感知，而且可以采用PLWH中的健康促进行为。该研究的具体目的是：1）描述和探索对CVD风险的看法以及采用健康促进行为的可能性，偏好，利益和障碍； 2.A.）制定一份治疗手册，以单独提供CVD风险评估和生活方式修改管理干预措施，以及2.b.。）进行试点研究，以测试2条工作干预的可行性和可接受性。第1阶段将包括30-40 PLWH的深入个人定性访谈。第2阶段将包括手动开发，是具有8-10 PLWH的初步协议的飞行员以及手动修订。阶段2.b。将包括一个随机的2臂（干预或简短建议）试验临床试验，其中40 plwh。从这项研究中获得的知识将为未来的全尺度随机临床试验的发展提供信息 检查量身定制的干预措施的有效性，以改善CVD风险感知，改善心脏健康行为的采用，并降低感染HIV感染的患者的CVD风险。拟议的K23研究将为我们对HIV感染患者的CVD风险的理解和管理贡献一个缺失和基本的因素。 PI将与经验丰富的导师合作以建立专业知识：（1）定性研究方法和分析； （2）干预开发和试点测试。该K23提案旨在解决HIV治疗科学的关键优先事项，并将为HIV干预科学家的研究职业做好准备。