Cardiovascular Risk Perception and Wellness Perspectives in HIV-infected Adults

HIV 感染者的心血管风险认知和健康观点

• 批准号: 8846418
• 负责人: Patricia Ann Cioe
• 金额: $ 13.23万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8846418
• 关键词: Accounting; Acute myocardial infarction; Address; Adopted; Adoption; Adult; Aerobic; Affect; Age; American Heart Association; Award; Awareness; Behavior; Behavior Therapy; Cardiovascular Diseases; Chronic; Chronic Disease; Clinical Trials; Comorbidity; Development; Diabetes Mellitus; Diet; Dyslipidemias; Effectiveness; Elements; Exercise; Feedback; Future; General Population; Goals; HIV; Health; Health behavior; Heart; High Prevalence; Hyperlipidemia; Hypertension; Individual; Inflammation; Intervention; Interview; Knowledge; Lead; Life; Link; Literature; Longevity; Manuals; Mentored Patient-Oriented Research Career Development Award; Mentors; Metabolic; Modeling; Morbidity - disease rate; Motivation; Nurses; Obesity; Participant; Patients; Perception; Persons; Phase; Physical activity; Pilot Projects; Primary Prevention; Process; Protocols documentation; Qualitative Methods; Qualitative Research; Randomized; Randomized Clinical Trials; Recommendation; Relative (related person); Research; Research Methodology; Research Training; Risk; Risk Assessment; Risk Factors; Role; Science; Scientist; Smoking; Structure; Techniques; Testing; Treatment Protocols; Work; aging population; arm; base; behavior change; brief advice; cardiovascular disorder risk; cardiovascular risk factor; career; experience; good diet; health belief; improved; innovation; mortality; motivated behavior; motivational enhancement therapy; phosphoribosylanthranilate isomerase; preference; public health relevance; risk perception; satisfaction; skills; theories; therapy development

DESCRIPTION (provided by applicant): This three-year K23 research and training award will enable the PI to acquire the knowledge and skills needed to become an independent nurse scientist, with the long-term goal of conducting research to develop and implement innovative interventions that reduce cardiovascular risk and promote wellness in HIV-infected patients. Cardiovascular disease (CVD) has emerged as a major cause of morbidity and mortality (evidenced by a higher rate of acute myocardial infarction at younger ages) in persons living with HIV (PLWH) compared with uninfected individuals. PLWH have a higher prevalence of traditional CVD risk factors, as well as increased comorbidities, such as hypertension, diabetes, obesity, and hyperlipidemia. Given the role of CVD in HIV-infected patients' mortality, understanding CVD risk perception and risk factor knowledge, and developing tailored interventions is imperative. This project draws on the Health Belief Model to better understand how PLWH perceive their risk for CVD, and to develop a motivational interviewing (MI)-based intervention to improve not only CVD risk perception but also the adoption of health-promoting behaviors in PLWH. The specific aims of the study are to: 1) describe and explore perceptions of CVD risk and the likelihood, preferences, benefits, and barriers of adopting health-promoting behaviors; 2.a.) develop a treatment manual for an individually delivered CVD risk assessment and lifestyle modification management intervention, and, 2.b.) conduct a pilot study to test the feasibility and acceptability of the 2-session intervention. Phase 1 will include in-depth individul qualitative interviews with 30-40 PLWH. Phase 2.a. will include manual development, a pilot of the preliminary protocol with 8-10 PLWH, and manual revisions. Phase 2.b. will include a randomized 2-arm (intervention or brief advice) pilot clinical trial with 40 PLWH. The knowledge gained from this study will inform the future development of a full-scale randomized clinical trial to examine the effectiveness of a tailored intervention to improve CVD risk perception, improve adoption of heart-healthy behaviors, and reduce CVD risk in HIV-infected patients. The proposed K23 research will contribute a missing and fundamental element to our understanding and management of CVD risk in HIV-infected patients. The PI will work with experienced mentors to build expertise in: (1) qualitative research methods and analyses; and, (2) intervention development and pilot testing. This K23 proposal addresses a key priority in HIV treatment science and will fully prepare the PI for a research career as an HIV intervention scientist.

描述（由申请人提供）：这个为期三年的 K23 研究和培训奖将使 PI 能够获得成为独立护士科学家所需的知识和技能，其长期目标是开展研究以开发和实施创新干预措施，降低心血管风险并促进艾滋病毒感染者的健康。与未感染者相比，心血管疾病（CVD）已成为艾滋病毒感染者（PLWH）发病和死亡的主要原因（年轻时急性心肌梗塞的发病率较高）。 PLWH 传统 CVD 危险因素的患病率较高，并且高血压、糖尿病、肥胖和高脂血症等合并症也较多。鉴于 CVD 在 HIV 感染者死亡率中的作用，了解 CVD 风险认知和风险因素知识并制定量身定制的干预措施势在必行。该项目利用健康信念模型来更好地了解 PLWH 如何看待自己的 CVD 风险，并开发基于动机访谈 (MI) 的干预措施，不仅改善 CVD 风险认知，还改善 PLWH 采取健康促进行为。该研究的具体目的是： 1) 描述和探索对 CVD 风险的看法以及采取健康促进行为的可能性、偏好、益处和障碍； 2.a.) 为单独实施的 CVD 风险评估和生活方式改变管理干预制定治疗手册，并且 2.b.) 进行试点研究以测试 2 次干预的可行性和可接受性。第一阶段将包括对 30-40 名感染者进行深入的个人定性访谈。阶段 2.a。将包括手册开发、针对 8-10 名 PLWH 的初步方案试点以及手册修订。阶段 2.b。将包括一项针对 40 名感染者的随机 2 臂（干预或简短建议）试点临床试验。从这项研究中获得的知识将为全面随机临床试验的未来发展提供信息 旨在检查定制干预措施的有效性，以改善艾滋病毒感染者的心血管疾病风险认知、改善心脏健康行为并降低心血管疾病风险。拟议的 K23 研究将为我们理解和管理 HIV 感染者的 CVD 风险提供一个缺失的基本要素。 PI 将与经验丰富的导师合作，建立以下方面的专业知识：(1) 定性研究方法和分析； (2) 干预措施开发和试点测试。这项 K23 提案解决了 HIV 治疗科学的一个关键优先事项，并将为 PI 为 HIV 干预科学家的研究生涯做好充分准备。