Neurocognitive Outcomes Following Proton Beam Radiation Therapy for Treatment of

质子束放射治疗后的神经认知结果

• 批准号: 8726734
• 负责人: LISA SCHUM KAHALLEY
• 金额: $ 14.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726734
• 关键词: Address; Aftercare; Age; Appointment; Area; Attention; Brain Neoplasms; Cancer Center; Cancer Patient; Cancer Survivor; Child; Childhood; Childhood Brain Neoplasm; Clinical; Cognitive; Country; Cranial Irradiation; Data; Data Collection; Decision Making; Destinations; Diagnostic; Doctor of Philosophy; Dose; Environment; Excision; Exhibits; Family; Family Physicians; Fostering; Functional disorder; Funding; Growth; Impaired cognition; Intervention; K-Series Research Career Programs; Late Effects; Literature; Malignant Neoplasms; Medical; Medicine; Mentors; Modality; Neurocognitive; Neuropsychology; Operative Surgical Procedures; Outcome; Outcomes Research; Patients; Pediatric Oncology; Performance; Photons; Population; Psychology; Publishing; Quality of life; Radiation therapy; Reporting; Research; Research Methodology; Research Personnel; Research Training; Risk; Risk Factors; Severities; Short-Term Memory; Site; Staging; Survival Rate; Survivors; Techniques; Technology; Texas; Time; Tissues; Training; Writing; base; brain tissue; brain volume; cancer care; chemotherapy; clinical care; clinical risk; clinically significant; cognitive function; college; comparison group; cost; disorder control; experience; frontier; functional disability; functional outcomes; improved; interest; irradiation; longitudinal design; neuro-oncology; oncology program; patient oriented; pediatric department; processing speed; professor; programs; prospective; proton beam; proton therapy; social; statistics; survivorship; theories; therapy development; tumor

DESCRIPTION (provided by applicant): This candidate, Lisa Schum Kahalley, PhD, is an Assistant Professor in the Section of Psychology, Department of Pediatrics, at Baylor College of Medicine, with a secondary appointment in the Texas Children's Cancer Center. The proposed career development award outlines critical mentoring, training, and research experiences to prepare Dr. Kahalley for an independent research program in neurocognitive late effects research. The mentoring committee supporting this application consists of experienced researchers and clinicians in pediatric neuropsychology (Doug Ris, PhD), neuro-oncology (Fatih Okcu, MD, Murali Chintagumpala, MD), and longitudinal statistics (Paras Mehta, PhD). They will oversee this candidate's specialized training in neuropsychology, longitudinal research methods, and scientific writing and grantsmanship to prepare her to transition into neurocognitive outcome research and research independence. The proposed research plan will provide applied experience in these specific areas of focus. Brain tumor survivors are at risk for lasting treatment-related cognitive impairment. Interest in the use of proton beam radiation therapy (PBRT) for treatment of pediatric brain tumor continues to grow as many believe this technique could improve survival rates while also preserving quality of life outcomes. Many herald the clinical potential of PBRT to spare cognitive functioning by minimizing damage to healthy brain tissue without sacrificing disease control. Still, there are no published reports to date of cognitive outcomes following PBRT for pediatric brain tumor. This proposal includes two studies, one cross-sectional and one longitudinal, designed to maximize the empirical yield for this 5-year funding period. Study 1 is a prospective, longitudinal examination of neurocognitive outcomes and changes over time among patients treated for pediatric brain tumors with PBRT versus surgery alone. Study 2 is a cross-sectional comparison of neurocognitive outcomes between survivors of pediatric brain tumor previously treated with PBRT versus conventional radiation therapy. This proposal is consistent with NCI's strategic objectives to improve the quality of life for cancer survivors, promote safe and equitable cancer care, and foster informed decision making. Results will have clinical value, providing a timely initial report of neurocognitive functioning and comparison between treatment modalities that will be a notable addition to the sparse existent literature in PBRT late effects. Remarkable advantages of this research environment will facilitate the successful execution of these studies. In particular, Texas Children's Cancer Center has one of the largest pediatric neuro-oncology programs in the country with access to one of the few proton therapy centers in the US currently open for the treatment of pediatric brain tumor.

描述（由申请人提供）：该候选人Lisa Schum Kahalley博士是贝勒医学院儿科学系心理学部门的助理教授，在德克萨斯州儿童癌症中心进行了次要任命。拟议的职业发展奖概述了Kahalley博士为神经认知后期效果研究的独立研究计划做准备的批判性指导，培训和研究经验。支持该应用的指导委员会由经验丰富的研究人员和临床医生在儿科神经心理学（Doug Ris，PhD），神经肿瘤学（Fatih Okcu，MD，Murali Chintagumpala，MD）和纵向统计学（Paras Mehta，Paras Mehta，Phd）组成。他们将监督该候选人在神经心理学，纵向研究方法以及科学写作和授予技巧方面的专门培训，以便她使她过渡到神经认知结果研究和研究独立性。拟议的研究计划将在这些特定重点领域提供应用经验。脑肿瘤幸存者有持久与治疗相关的认知障碍的风险。对使用质子束放射疗法（PBRT）治疗小儿脑肿瘤的兴趣继续增长，因为许多人认为这种技术可以提高生存率，同时还可以保留生活质量。许多人通过最大程度地减少对健康脑组织的损害而无需牺牲疾病控制，使PBRT的临床潜力避免了认知功能。尽管如此，迄今为止，在PBRT尚未发布小儿脑肿瘤后的认知结果报告。该提案包括两项研究，一项横断面和一个纵向，旨在最大程度地提高这个5年资金期间的经验产量。研究1是对神经认知结果的前瞻性，纵向检查，并且随着时间的流逝，患有PBRT与手术相对于手术的儿科脑肿瘤的患者中随着时间的流逝而变化。研究2是对先前用PBRT与常规放射治疗治疗的小儿脑肿瘤幸存者之间神经认知结果的横断面比较。该提案与NCI的战略目标是一致的，旨在改善癌症幸存者的生活质量，促进安全且公平的癌症护理以及促进知情决策。结果将具有临床价值，提供了及时的初步报道，报告了神经认知功能和治疗方式之间的比较，这将是PBRT晚期效应中存在的稀疏文献的显着补充。该研究环境的显着优势将有助于成功执行这些研究。特别是，得克萨斯州儿童癌症中心是该国最大的儿科神经肿瘤学计划之一，目前可以使用目前为儿童脑肿瘤治疗的美国少数质子治疗中心之一。