Support for GENESIS

支持创世纪

基本信息

批准号：
8287589
负责人：
JAMES M BOWER
金额：
$ 28.65万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8287589
关键词：
19 year old Access to Information Basic Science Biological Biological Models Book Chapters Books Brain Brazil Code Collaborations Communities Computer software Continuing Education Data Databases Development Education Educational Curriculum Educational process of instructing European Union Extensible Markup Language Foundations Functional disorder Funding Grant Growth India Instruction Internet Japan Laboratories Latin America Link Maintenance Marines Measures Medical Medical Education Medical Students Medicine Methods Mexico Modeling Molecular Morphology Nature Nervous system structure Neurobiology Neurons Online Systems Pathway interactions Peer Review Physicians Play Publications Publishing Recording of previous events Reporting Research Role Series Stream Structure Students Support System System Technology Text Time Translational Research United States National Institutes of Health Universities Update Wood material base biological research clinical Diagnosis college computational neuroscience design flexibility journal article medical schools meetings model development multi-scale modeling open source prototype relating to nervous system simulation software development software systems tool

项目摘要

DESCRIPTION (provided by applicant): The General Neural Simulation System (GENESIS) was first released for general use in 1988 as part of the first Methods in Computational Neuroscience Meeting at the Marine Biological Laboratory in Woods Hole, MA. Since its original release 19 years ago, GENESIS has provided one of the foundations for the growth of computational neuroscience both continuing to support education as well as research. With respect to summer courses, GENESIS continues to be part of the course in Woods Hole, as well as courses offered in the European Union, Mexico, India, Japan, and recently a new course in Brazil for Latin America. At last count GENESIS has also provided support for courses in at least 61 colleges and universities around the world where it has been used both as an instruction tool in realistic modeling of the nervous system, and as a simulation based tool for neurobiological education in general. The Book of GENESIS (Bower and Beeman, 1994, 1998), which was designed to support both computational and neurobiological instruction has sold more than 6,000 copies worldwide with more than double that number of copies having been distributed with the text now freely available on the Internet (Bower and Beeman, 2003). This substantial support for the use of GENESIS in instruction has also provided the base for extensive and growing use of this software system in biological research. Although certainly an underestimate, we are aware of 297 published GENESIS-dependent peer reviewed journal articles and book chapters not directly related to research in the P.I.'s laboratory. Further, more than a third of those reports (103) have been published during the period January 2004 to June 2007 (approximately the duration of the current NIH grant). As measured by the subjects of these publications, use of GENESIS has a growing emphasis on two types of simulations, those of large scale networks (using the parallel version of the platform), and those involving molecular biological modeling. GENESIS remains the only simulation system specifically designed from the outset to link multi-scale modeling efforts. With this grant, we seek continuing funding to support the expanding use of GENESIS, but also and importantly, to complete the implementation of a new version of the GENESIS platform. While maintaining backwards compatibility, GENESIS 3.0 is a complete rewrite and redesign of the system, replacing a 19-year-old structure. The rewrite will update and upgrade core GENESIS functionality while adding important new features, including model history control and tracking, a new web browser interface, and new features to support education as well as scholarly publication of models. Project Narrative Biological simulation technology is becoming an increasingly important part of both basic and translational research in medicine. The GENESIS system supported by this grant is one of the most used software systems supporting this type of research in the US, and will provide continuing support for the use and further development of this modeling platform. Newly proposed extensions include applications to medical education and scientific publishing as well as the continuing efforts to understand brain function and dysfunction.

描述（由申请人提供）：通用神经模拟系统 (GENESIS) 于 1988 年首次发布供一般使用，作为在马萨诸塞州伍兹霍尔海洋生物实验室举行的首届计算神经科学方法会议的一部分。自 19 年前首次发布以来，GENESIS 为计算神经科学的发展提供了基础之一，并继续支持教育和研究。在夏季课程方面，GENESIS 继续成为伍兹霍尔课程的一部分，以及在欧盟、墨西哥、印度、日本提供的课程，以及最近在巴西为拉丁美洲开设的新课程。根据最新统计，GENESIS 还为全球至少 61 所学院和大学的课程提供了支持，在这些学院和大学中，它既被用作神经系统真实建模的教学工具，也被用作一般神经生物学教育的基于模拟的工具。《GENESIS》（Bower 和 Beeman，1994，1998）旨在支持计算和神经生物学教学，已在全球售出 6,000 多册，其中已发行数量的两倍多，文本现在可以在互联网（鲍尔和比曼，2003）。对 GENESIS 在教学中的使用的大力支持也为该软件系统在生物研究中的广泛和不断增长的使用奠定了基础。虽然肯定低估了，但我们知道有 297 篇已发表的依赖 GENESIS 的同行评审期刊文章和书籍章节，与 P.I. 实验室的研究没有直接关系。此外，其中超过三分之一的报告 (103) 是在 2004 年 1 月至 2007 年 6 月期间发表的（大约是当前 NIH 拨款的期限）。从这些出版物的主题来看，GENESIS 的使用越来越强调两种类型的模拟，即大规模网络模拟（使用平台的并行版本）和涉及分子生物建模的模拟。 GENESIS 仍然是唯一从一开始就专门设计用于链接多尺度建模工作的仿真系统。通过这笔赠款，我们寻求持续的资金来支持 GENESIS 的扩大使用，而且重要的是，完成新版本 GENESIS 平台的实施。在保持向后兼容性的同时，GENESIS 3.0对系统进行了彻底的重写和重新设计，取代了已有19年历史的结构。此次重写将更新和升级 GENESIS 的核心功能，同时添加重要的新功能，包括模型历史控制和跟踪、新的 Web 浏览器界面以及支持教育和模型学术出版的新功能。项目叙述生物模拟技术正在成为医学基础研究和转化研究日益重要的组成部分。这笔赠款支持的 GENESIS 系统是美国支持此类研究最常用的软件系统之一，并将为该建模平台的使用和进一步开发提供持续支持。新提出的扩展包括医学教育和科学出版的应用以及理解大脑功能和功能障碍的持续努力。