Investigating diversity within the MR1-restricted T cell repertoire in humans

研究人类 MR1 限制性 T 细胞库的多样性

• 批准号: nhmrc : GNT1159932
• 金额: $ 88.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-diversity-mr1-repertoire-humans/1379100
• 关键词: Investigating; diversity; within; MR1; restricted

T cells are a critical component of the immune system that can recognise infected host cells. However, there remains many facets of T cell function that we do not understand. This project aims to investigate a major aspect of T cell-mediated immunity that is poorly understood, namely, T cell immunity to metabolites. Specifically, using a multi-disciplinary approach, this project will unearth the molecular correlates of metabolite-based immunity in humans.

T 细胞是免疫系统的重要组成部分，可以识别受感染的宿主细胞。然而，T 细胞功能的许多方面仍然是我们不了解的。该项目旨在研究人们知之甚少的 T 细胞介导免疫的一个主要方面，即 T 细胞对代谢物的免疫。具体来说，该项目将采用多学科方法，揭示人类代谢物免疫的分子相关性。