Translational Research in GI Cancer

胃肠道癌症的转化研究

• 批准号: 8868250
• 负责人: Dean E. Brenner
• 金额: $ 2.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-13 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8868250
• 关键词: Address; Biological Markers; Biometry; Chemopreventive Agent; Clinical; Clinical Investigator; Colorectal Cancer; Complement; DNA Damage; Development; Early Detection Research Network; Early Diagnosis; Event; Fish Oils; Funding; Health; Health Sciences; Individual; Informatics; Institutes; Intervention; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Methods; Michigan; Molecular; Morbidity - disease rate; Phenotype; Preventive; Preventive Intervention; Radiation induced damage; Research; Research Personnel; Resources; Risk; Risk Assessment; Scientist; Southwest Oncology Group; Specialized Program of Research Excellence; Sum; Translational Research; Universities; University of Michigan Comprehensive Cancer Center; Validation; anticancer research; carcinogenesis; career development; flexibility; improved; medical schools; mortality; multidisciplinary; programs; repaired; response

DESCRIPTION (provided by applicant): A Specialized Program of Research Excellence (SPORE) entitled "Translational Research in Gl Cancer" is proposed to tap the vast intellectual and physical resources of the University of Michigan to decrease the morbidity and mortality from pancreatic and colorectal cancers. The SPORE will address the hypothesis that identifying and developing interventions to address molecular events that enhance cellular carcinogenesis or cellular transformed phenotype will reduce the morbidity and mortality associated with colorectal and pancreatic cancers through risk identification, preventive interventions, early detection, or improved treatment of invasive cancer. This integrated translational research program consists of four major projects that explore 1) fish oil intervention as a chemopreventive for colorectal cancer; 2) development and validation of biomarkers for the early detection of pancreatic and colorectal cancer using glycoproteomics methods; 3) targeted inhibition of Chk1 as a mechanism to reduce repair of radiation induced damage to pancreatic cancer; and 4) improved treatment of pancreatic cancer through targeted inhibition of ATDC to reduce DNA damage response. These major translational projects are complemented by Career Development and Developmental Research Programs that identify new risk assessment, preventive and treatment targets for colorectal and pancreatic cancers. All SPORE studies will be supported by three Core Resources (Administrative, Biostatistics and Informatics, and Biosample). The SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. The SPORE is also integrated into the University of Michigan's Institute for Clinical and Health Research, a new translational research resource for the Medical School and Health Sciences Campus. The SPORE integrates other SPORE programs and links the National SPORE program to other national cancer research resources such as the Early Detection Research Network and the Southwest Oncology Group. This Gl SPORE places premiums on rigorous scientific review of its translational research programs, pairing of basic and clinical investigators, drawing on the expertise of diverse scientists, and utilizing flexibility to fund promising new research approaches. The interaction of our multidisciplinary group of investigators makes the Gl SPORE at the University of Michigan Comprehensive Cancer Center greater than the sum of its individual parts.

描述（由申请人提供）：提议题为“胃肠道癌症转化研究”的专业卓越研究计划（SPORE），旨在利用密歇根大学丰富的智力和物质资源来降低胰腺癌和结直肠癌的发病率和死亡率。 SPORE 将提出这样一个假设：识别和开发干预措施来解决增强细胞癌变或细胞转化表型的分子事件，将通过风险识别、预防性干预、早期检测或改进侵袭性治疗来降低结直肠癌和胰腺癌相关的发病率和死亡率。癌症。该综合转化研究计划由四个主要项目组成，探索：1）鱼油干预作为结直肠癌的化学预防； 2）利用糖蛋白组学方法开发和验证用于早期检测胰腺癌和结直肠癌的生物标志物； 3）靶向抑制Chk1作为减少胰腺癌辐射损伤修复的机制； 4) 通过靶向抑制 ATDC 以减少 DNA 损伤反应，改善胰腺癌的治疗。这些重大转化项目得到了职业发展和发展研究计划的补充，这些计划确定了结直肠癌和胰腺癌的新风险评估、预防和治疗目标。所有 SPORE 研究将得到三个核心资源（管理、生物统计和信息学以及生物样本）的支持。 SPORE 是密歇根大学综合癌症中心的一个完全集成的组成部分。 SPORE 还被纳入密歇根大学临床与健康研究所，成为医学院和健康科学校区的新转化研究资源。 SPORE 整合了其他 SPORE 计划，并将国家 SPORE 计划与其他国家癌症研究资源（例如早期检测研究网络和西南肿瘤学组）联系起来。 GL SPORE 重视对其转化研究项目进行严格的科学审查、基础研究人员和临床研究人员的配对、利用不同科学家的专业知识，并利用灵活性来资助有前途的新研究方法。我们的多学科研究小组的相互作用使得密歇根大学综合癌症中心的 Gl SPORE 大于其各个部分的总和。