Physiologically Based Markers of Idiopathic Intracranial Hypertension

特发性颅内高压的生理标志物

• 批准号: 8679930
• 负责人: Heather Elspeth Moss
• 金额: $ 21.13万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8679930
• 关键词: Affect; Aftercare; Age; Analysis of Variance; Area; Award; Biological Markers; Blindness; Blood Pressure; Blood Vessels; Brain; Caliber; Caring; Cell physiology; Cerebrovascular Disorders; Clinical; Clinical Management; Clinical Research; Clinical Trials; Commit; Control Groups; Development; Diagnosis; Disease; Disease Outcome; Electrophysiology (science); Ensure; Environment; Equation; Eye; Foundations; Functional disorder; Glaucoma; Goals; Height; Image; Impairment; Incidence; Injury; Institution; Intracranial Hypertension; Intracranial Pressure; K-Series Research Career Programs; Knowledge; Lasers; Leadership; Light; Measures; Mechanics; Mentors; Mentorship; Modeling; Monitor; Morbidity - disease rate; Nerve; Neurology; Obesity; Ophthalmologist; Ophthalmology; Optic Disk; Optic Nerve; Optical Coherence Tomography; Outcome; Outcome Measure; Papilledema; Patients; Perimetry; Peripheral; Physicians; Physiological; Physiology; Pilot Projects; Plant Roots; Population; Principal Investigator; Productivity; Pseudotumor Cerebri; Pupil; Recruitment Activity; Request for Applications; Research; Research Personnel; Research Project Grants; Retinal; Retinal Ganglion Cells; Risk; Scanning; Scientific Advances and Accomplishments; Scientist; Spinal Puncture; Spinal Tap; Structure; Swelling; Techniques; Testing; Therapeutic; Thick; Time; Training; Translational Research; Uncertainty; Veins; Vision; Vision research; Visual; Visual Pathways; Visual Psychophysics; Work; base; career; career development; clinical care; clinical epidemiology; experience; hypertension treatment; improved; interest; medical schools; non-invasive imaging; ophthalmic artery; optic nerve disorder; patient oriented; pressure; programs; public health relevance; response; retina blood vessel structure; retinal nerve fiber layer; success; tool; vision science; visual information; young woman

Project Summary/Abstract This application requests a career development award for an academic neuro-ophthalmologist with a scientific interest in idiopathic intracranial hypertension (IIH), a potentially blinding condition that most commonly affects young women. This award will provide the candidate with the necessary mentorship, training and experience to propel her to the level of independent patient oriented researcher focused on advancing diagnosis, clinical care and outcomes of IIH. The candidate is an accomplished early career physician-scientist. In the short term she seeks research career development in the areas of clinical research & epidemiology, visual psychophysics & electrophysiology and neuro-ophthalmic imaging. She will develop her knowledge and capabilities in these areas through coursework, guided study, practical experience and mentored research. This will form the foundation upon which she will build an independent research program in IIH. From this vantage point she will pursue her long term goal of improving clinical care for IIH and other neuro-ophthalmic conditions both as an independent researcher with a strong translational research program and as an expert clinician caring directly for patients. The environment created by the Department, Medical School and Institution is characterized by clinical and research expertise and productivity. There is a proven track record of effectively nurturing early career physician scientists in the fields of ophthalmology and vision research. Departmental and Medical School leadership are committed to providing material, financial and intellectual support to ensure the candidate's development and success. There is a significant clinical need for non-invasive biomarkers that will improve diagnosis and management of IIH. The objective of the research project is to establish physiologically based markers of retinal ganglion cell (RGC) function and retinal vasculature as markers of IIH that detect abnormalities, monitor treatment and distinguish peripheral vision outcomes. This objective will be accomplished with two specific aims: 1. To test the hypothesis that RGC function is impaired and retinal vascular diameters are enlarged in IIH subjects as compared to visually normal control subjects: Electrophysiological and pupil light response based measures of RGC function and image based measures of retinal blood vessel diameter will be compared between IIH subjects with elevated intracranial pressure and control subjects. This will establish that these markers are abnormal in the IIH population. 2. To test the hypothesis that RGC function impairment and retinal vascular dilation recover in IIH subjects with short and long term treatment: Electrophysiological and pupil light response based measures of RGC function and image based measures of retinal blood vessel diameter will be compared within IIH subjects when intracranial pressure is elevated, immediately following short term intracranial pressure lowering by lumbar puncture and following long term intracranial pressure lowering by standard clinical therapy. This will establish that these markers change with treatment of IIH. The results of the proposed study will lay the scientific and technical foundation for the development of these markers as clinical tools and clinical trial outcome measures of IIH. Furthermore, the results will advance scientific understanding of the pathophysiology underlying optic nerve dysfunction and injury in IIH. The project has broader significance because the knowledge gained and technical capabilities developed will have applications to other diseases at the intersection of neurology and ophthalmology such as glaucoma and cerebrovascular disease. The research career development and mentoring plan will transform the candidate into an independent researcher who will make long-lasting contributions to vision science.

项目摘要/摘要 该申请要求为学术神经 - 跨性病学家颁发职业发展奖，并具有科学 对特发性颅内高血压（IIH）的兴趣，这是一种可能最常见的盲目疾病 年轻女性。该奖项将为候选人提供必要的指导，培训和经验 将她推向注重诊断的独立患者研究人员的水平 IIH的护理和结果。 候选人是一位出色的早期职业医师科学家。在短期内她寻求研究 临床研究与流行病学，视觉心理物理学和电生理学领域的职业发展 和神经性跨心理成像。她将通过这些领域发展自己的知识和能力 课程工作，指导性学习，实践经验和指导研究。这将构成基础 她将在IIH建立一个独立的研究计划。从这个有利的角度，她将追求她的长时间 改善IIH临床护理和其他神经感觉状况的术语目标都是独立的 具有强大转化研究计划的研究人员，并且是专家临床医生，直接照顾患者。 部门，医学院和机构创建的环境的特征是临床和 研究专业知识和生产力。有一个有效培养早期职业的可靠记录 眼科和视力研究领域的医师科学家。系 领导力致力于提供材料，财务和智力支持，以确保候选人的 发展与成功。 对非侵入性生物标志物的临床需求很大，可以改善诊断和管理 IIH。研究项目的目的是建立视网膜神经节的基于生理的标记 细胞（RGC）功能和视网膜脉管系统作为IIH的标记，检测异常，监测治疗和 区分外围视力结果。这个目标将以两个具体的目的来实现： 1。测试RGC功能受损的假设，视网膜血管直径扩大 IIH受试者与视觉正常对照受试者相比：电生理和学生光 基于响应的RGC功能和基于图像的视网膜血管直径的度量将是 在颅内压和对照受试者升高的IIH受试者之间进行了比较。这将建立 这些标记在IIH人群中是异常的。 2。测试RGC功能障碍和视网膜血管扩张恢复IIH的假设 短期和长期治疗的受试者：基于电生理和学生光反应的措施 在IIH中将比较RGC功能和基于图像的视网膜血管直径的度量 当颅内压升高时，受试者立即在短期颅内压降低后立即 通过腰椎穿刺和长期颅内压后，通过标准临床疗法降低。这 将确定这些标记随处理IIH的处理而变化。 拟议研究的结果将奠定这些发展的科学技术基础 标记是IIH的临床工具和临床试验结果指标。此外，结果将进步 对IIH中视神经功能障碍和损伤的病理生理学的科学理解。这 项目具有更广泛的意义，因为获得的知识和开发的技术能力将具有 在神经病学和眼科的交集中的其他疾病的应用，例如青光眼和 脑血管疾病。研究职业发展和指导计划将改变候选人 成为一个独立的研究人员，他将为视觉科学做出持久的贡献。