HYPOGLYCEMIA AND HYPERGLYCEMIA IN DEVELOPING BRAIN

大脑发育中的低血糖和高血糖

• 批准号: 8362842
• 负责人: RADHAKRISHNA RAO
• 金额: $ 1.51万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362842
• 关键词: Acute; Animal Model; Brain; Functional disorder; Funding; Glucose; Grant; Hippocampus (Brain); Human; Hyperglycemia; Hypoglycemia; Magnetic Resonance Imaging; Metabolic; NMR Spectroscopy; National Center for Research Resources; Newborn Infant; Plasma; Principal Investigator; Process; Rattus; Recurrence; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; brain cell; cost; neurochemistry; pup

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hypoglycemia is a common metabolic condition in newborn infants. Prolonged and recurrent hypoglycemia is associated with long-term hippocampal dysfunction. Despite extensive studies in humans and animal models, detailed mechanism is not well understood, especially the sequel of different processes providing fuel for brain cells, when glucose plasma is too low. The purpose of this project is to quantify neurochemical changes during acute and recurrent hypoglycemia on the hippocampus of rat pups using 1H NMR spectroscopy at 9.4 T.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 低血糖是新生儿常见的代谢状况。长期和反复发生的低血糖与长期海马功能障碍有关。尽管对人类和动物模型进行了广泛的研究，但详细的机制尚不清楚，特别是当葡萄糖血浆过低时为脑细胞提供燃料的不同过程的后续结果。该项目的目的是使用 9.4 T 的 1H NMR 光谱来量化幼鼠海马急性和复发性低血糖期间的神经化学变化。