TESTOSTERONE AND GROWTH HORMONE IMPROVE BODY COMPOSITION AND

睾酮和生长激素改善身体成分

• 批准号: 8361388
• 负责人: FRED R SATTLER
• 金额: $ 1.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361388
• 关键词: Adult; Age-Years; Aging; Body Composition; Body fat; Communities; Enrollment; Funding; Grant; Impairment; Insulin-Like Growth Factor I; Intervention; Investigation; Leuprolide Acetate; Masks; Mass Spectrum Analysis; Muscle function; National Center for Research Resources; Physiological; Principal Investigator; Randomized; Research; Research Infrastructure; Resources; Somatotropin; Source; Supplementation; Testing; Testosterone; United States; United States National Institutes of Health; Universities; biomedical resource; cost; improved; men; muscle form; older men; pituitary gonadal axis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. With aging, impairments in the pituitary-gonadal axis are associated with loss of muscle mass and function and accumulation of upper body fat. We tested the hypothesis that physiologic supplementation with testosterone and growth hormone together improves body composition and muscle function in 65-90 year-old men with low testosterone and IGF-1 levels. This was a factorial (2X3) two tiered, randomized, double masked investigation conducted at three university research centers located in the western, central and eastern United States. We enrolled 122 community dwelling men 70.8¿4.2 years-of-age with BMI=27.4¿3.4kg/m2, testosterone d19.1nmol/L (550ng/dL) and IGF-1 in lower adult tertile (d21.9nmol/L=167ng/dL). The interventions included transdermal testosterone (5g or 10g/day) during suppression of endogenous testosterone with leuprolide acetate (7.5mg/monthly) and growth hormone (0, 3, or 5ug/kg/day) for 16 weeks.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供 该子项目的主要支持。 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源的子项目可能列出的总成本。 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 随着年龄的增长，垂体-性腺轴的损伤与肌肉质量和功能的丧失以及上半身脂肪的积累有关，我们测试了这样的假设：睾酮和生长激素的生理补充可以改善 65-90 岁的身体成分和肌肉功能。 - 睾酮和 IGF-1 水平较低的老年男性 这是一项在美国西部、中部和东部的三个大学研究中心进行的阶乘 (2X3) 两级、随机、双盲调查。 122 名 70.8¿4.2 岁的社区居民男性，BMI=27.4¿3.4kg/m2，睾酮 d19.1nmol/L (550ng/dL) 和 IGF-1 处于较低的成人三分位数 (d21.9nmol/L=167ng/干预措施包括在抑制内源性睾酮期间透皮睾酮（5g 或 10g/天）。醋酸亮丙瑞林（7.5 毫克/月）和生长激素（0、3 或 5 微克/公斤/天），持续 16 周。