EXERCISE TRAINING AUGMENTS THE PERIPHERAL INSULIN SENSITIZING EFFECTS

运动训练增强外周胰岛素增敏作用

• 批准号: 8361446
• 负责人: Dominic N Reeds
• 金额: $ 2.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361446
• 关键词: Adult; Aerobic; Agonist; Euglycemic Clamping; Exercise; Funding; General Population; Glucose Clamp; Grant; HIV-1; Incidence; Infection; Insulin; Insulin Resistance; Mass Spectrum Analysis; National Center for Research Resources; Non-Insulin-Dependent Diabetes Mellitus; Obesity; PPAR gamma; Peripheral; Pioglitazone; Prevalence; Principal Investigator; Randomized; Research; Research Infrastructure; Resistance; Resources; Source; Training; United States National Institutes of Health; biomedical resource; cost; design; effective intervention; improved; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background. The prevalence and incidence of insulin resistance and type 2 diabetes (DM) are higher in people treated for human immunodeficiency virus-1 (HIV) infection than in the general population. Identifying safe and effective interventions is a high priority. Objective. We evaluated whether the peroxisome proliferator activated receptor-gamma agonist pioglitazone with exercise training improves central and peripheral insulin sensitivity more than pioglitazone alone in HIV infected adults with insulin resistance and central adiposity. Design. Forty-four HIV infected adults with baseline insulin resistance and central adiposity were randomly assigned to 4-months of pioglitazone (30mg/d) with or without supervised, progressive aerobic and resistance exercise training (11/2 -2 hr/d, 3 days/wk). The hyperinsulinemic-euglycemic clamp was used to evaluate alterations in central and peripheral insulin sensitivity.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 背景。在接受 1 型人类免疫缺陷病毒 (HIV) 感染治疗的人群中，胰岛素抵抗和 2 型糖尿病 (DM) 的患病率和发病率高于一般人群。确定安全有效的干预措施是当务之急。客观的。我们评估了在患有胰岛素抵抗和中枢性肥胖的艾滋病毒感染成人中，过氧化物酶体增殖物激活受体-γ激动剂吡格列酮联合运动训练是否比单独使用吡格列酮更能改善中枢和外周胰岛素敏感性。设计。 44 名基线胰岛素抵抗和中心性肥胖的 HIV 感染成年人被随机分配接受 4 个月的吡格列酮（30 毫克/天）治疗，有或没有监督、渐进式有氧运动和抗阻运动训练（11/2 -2 小时/天，3 天） /周）。高胰岛素正常血糖钳夹用于评估中枢和外周胰岛素敏感性的变化。