Washington University Institute of Clinical and Translational Sciences (KL2)

华盛顿大学临床与转化科学研究所 (KL2)

• 批准号: 10556451
• 负责人: Dominic N Reeds
• 金额: $ 140.02万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-19 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556451
• 关键词: Address; Area; Assessment tool; Bibliography; Black race; COVID-19; COVID-19 mortality; COVID-19 testing; Certification; Characteristics; Child; Clinical; Clinical Investigator; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Colorado; Communities; Competence; Data; Data Science; Development; Discipline; Disease; Educational Curriculum; Educational process of instructing; Educational workshop; Faculty; Fostering; Foxes; Goals; Hospitals; Hybrids; Improve Access; Individual; Informatics; Infrastructure; Institutes; Institution; K-Series Research Career Programs; Leadership; Longevity; Manuals; Measures; Medicine; Mentors; Mentorship; Methods; Mitochondrial DNA; Modeling; Outcome; Patients; Performance; Population; Powder dose form; Process; Program Development; Research; Research Personnel; Research Support; Research Training; Resource Sharing; Resources; Review Literature; Science; Self Assessment; Services; Site; Special Population; System; Technology; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Washington; Workforce Development; austin; base; career; career development; community engaged research; course development; education resources; faculty mentor; flexibility; health equity; implementation science; improved; informatics training; innovation; insight; leadership development; multidisciplinary; online course; programs; racial disparity; recruit; research and development; satisfaction; skills; success; tool; translational goal; translational scientist

Contact PD/PI: Powderly, William G. Inst-Career-Dev-001 (463) I. Institutional Career Development Core (KL2), 7. Project Summary/Abstract: The goal of the Washington University (WU) KL2 Career Development Program is to provide team-oriented, competency-based, multidisciplinary mentored research training, didactic coursework, and professional development for junior faculty. Our Clinical ResearchTraining Center (CRTC) provides educational resources and infrastructure for the WU Institute of Clinical and Translational Science (ICTS) and partner institutions. We are requesting 9 KL2 slots to support junior faculty for 2-3 years. To enhance our successful KL2, we will develop additional innovative coursework, training and career development programs across the full spectrum of T1-T4 research, emphasizing informatics and data science, health equity and implementation for impact. To address the regional and national CTSA goals, we propose the following specific aims: 1: Enhance the CRTC and KL2 infrastructure and programs to provide personalized, competency- based, rigorous, high-impact clinical/translational research training and skills. We will develop and provide new curricula and training programs emphasizing implementation science for impact and equity. We will enhance our hybrid and online courses to improve access and flexibility for trainees and share materials with ICTS partners and other CTSA hubs. (CTSA Goal:Translational Workforce Development) 2: Provide high-quality, informatics training. We will enhance our informatics and data science training (workshops, seminars, courses, certificates, and degrees), and integrate new informatics methods, tools and skills into our courses and training programs to meet individual scholar needs. (CTSA Goal: Informatics) 3: Expand the number and diversity of investigators leading high-impact, multidisciplinary, clinical/translational research teams. We will train scholars, faculty and mentors from diverse disciplines and promote recruitment and retention of faculty and scholars from under-represented in medicine (URiM) groups. To expand high-impact research in diverse communities and populations across the lifespan, we will integrate new team-science, URiM focused mentoring and leadership development into our courses and career development programs (CTSA Goals: Integrating Special Populations across the Lifespan) 4: Increase collaborations between the faculty, mentors, and scholars in the KL2 program and stakeholders, ICTS program functions, partners, and CTSA hubs. We will create new resources, share best practices, and advance diverse interdisciplinary scientific teams to foster patient and community engaged research and training at local, regional, and national levels. (CTSA Goal: Collaboration and Engagement) 5: Demonstrate the impact of the KL2 program. We will assess the short- and long-term performance of scholars, determine the efficacy of training methods, and use this data to improve training, trainee and faculty satisfaction, mentoring, diversity, leadership and outcomes. (CTSA Goal: Methods and Processes) Project Summary/Abstract Page 1137 Contact PD/PI: Powderly, William G. Inst-Career-Dev-001 (463) I. Institutional Career Development Core: KL2 Component 9. Bibliography and References Cited 1. Tsevat J, Smyth SS. Training the translational workforce: Expanding beyond translational research to include translational science. J Clin Transl Sci. 2020 Apr 6;4(4):360-362. PMCID: PMC7681113. 2. Sorkness CA, Scholl L, Fair AM, Umans JG. KL2 mentored career development programs at clinical and translational science award hubs: Practices and outcomes. J Clin Transl Sci. 2020 Feb;4(1):43-52. PMCID: PMC7103475. 3. Robinson GF, Schwartz LS, DiMeglio LA, Ahluwalia JS, Gabrilove JL. Understanding Career Success and Its Contributing Factors for Clinical and Translational Investigators. Acad Med. 2016 Apr;91(4):570-82. PMCID: PMC4811729. 4. Guerrero LR, Nakazono T, Davidson PL. NIH Career Development Awards in Clinical and Translational Science Award institutions: distinguishing characteristics of top performing sites. Clin Transl Sci. 2014 Dec;7(6):470-5. PMCID: PMC4361077. 5. Scozzi D, Cano M, Ma L, Zhou D, Zhu JH, O'Halloran JA, Goss C, Rauseo AM, Liu Z, Sahu SK, Peritore V, Rocco M, Ricci A, Amodeo R, Aimati L, Ibrahim M, Hachem R, Kreisel D, Mudd PA, Kulkarni HS, Gelman AE. Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19. JCI Insight. 2021 Feb 22;6(4). PMCID: PMC7934921. 6. Mody A, Pfeifauf K, Geng EH. Using Lorenz Curves to Measure Racial Inequities in COVID-19 Testing. JAMA Netw Open. 2021 Jan 4;4(1):e2032696. PMCID: PMC7794664. 7. Mody A, Lyons PG, Guillamet CV, Michelson A, Yu S, Namwase AS, Sinha P, Powderly WG, Woeltje K, Geng EH. The Clinical Course of COVID-19 Disease in a US Hospital System: a Multi-state Analysis. Am J Epidemiol. 2020 Dec 22. PMCID: PMC7799307. 8. Mody A, Pfeifauf K, Bradley C, Fox B, Hlatshwayo MG, Ross W, Sanders-Thompson V, Joynt K, Reidhead M, Schootman M, Powderly WG, Geng EH. Understanding Drivers of COVID-19 Racial Disparities: A Population-Level Analysis of COVID-19 Testing among Black and White Populations. Clin Infect Dis. 2020 Dec 14. PMCID: PMC7799327. 9. https://crtc.wustl.edu/resources/otg. 10. https://icts.wustl.edu/research-services/research-development-program/. 11. Sweeney C, Schwartz LS, Toto R, Merchant C, Fair AS, Gabrilove JL. Transition to Independence: Characteristics and Outcomes of Mentored Career Development (KL2) Scholars at Clinical and Translational Science Award Institutions. Acad Med. 2017 Apr;92(4):556-562. PMCID: PMC5373479. 12. Abedin Z, Biskup E, Silet K, Garbutt JM, Kroenke K, Feldman MD, McGee R, Jr., Fleming M, Pincus HA. Deriving competencies for mentors of clinical and translational scholars. Clin Transl Sci. 2012 Jun;5(3):273-80. PMCID: PMC3476465. 13. Keyser DJ, Lakoski JM, Lara-Cinisomo S, Schultz DJ, Williams VL, Zellers DF, Pincus HA. Advancing institutional efforts to support research mentorship: a conceptual framework and self-assessment tool. Acad Med. 2008 Mar;83(3):217-25. 14. https://cimerproject.org/entering-mentoring/ 15. Meagher E, Taylor L, Probsfield J, Fleming M. Evaluating research mentors working in the area of clinical translational science: a review of the literature. Clin Transl Sci. 2011 Oct;4(5):353-8. PMCID: PMC3727275. 16. Nearing KA, Nuechterlein BM, Tan S, Zerzan JT, Libby AM, Austin GL. Training Mentor-Mentee Pairs to Build a Robust Culture for Mentorship and a Pipeline of Clinical and Translational Researchers: The Colorado Mentoring Training Program. Acad Med. 2020 May;95(5):730-736. PMCID: PMC7644265. 17. https://crtc.wustl.edu/wp-content/uploads/CRTC_Teaching-with-Technology-Manual.pdf 18. https://www.ahrq.gov/teamstepps/master-training-course.html. 19. Byington CL, Keenan H, Phillips JD, Childs R, Wachs E, Berzins MA, Clark K, Torres MK, Abramson J, Lee V, Clark EB. A Matrix Mentoring Model That Effectively Supports Clinical and Translational Scientists and References Cited Page 1138

联系 PD/PI：Powderly, William G. Inst-Career-Dev-001 (463) I. 机构职业发展核心（KL2），7. 项目摘要/摘要： 华盛顿大学 (WU) KL2 职业发展计划的目标是提供以团队为导向的、 基于能力的、多学科指导的研究培训、教学课程和专业 初级教师的发展。我们的临床研究培训中心 (CRTC) 提供教育资源 西弗吉尼亚大学临床与转化科学研究所 (ICTS) 和合作机构的基础设施和基础设施。 我们请求 9 个 KL2 名额来支持初级教师 2-3 年。为了增强我们成功的 KL2，我们将 开发更多创新课程、培训和职业发展计划 T1-T4 研究范围，强调信息学和数据科学、健康公平和实施 影响。为了实现区域和国家 CTSA 目标，我们提出以下具体目标： 1：加强 CRTC 和 KL2 基础设施和计划，以提供个性化、能力化的服务 基于的、严格的、高影响力的临床/转化研究培训和技能。我们将开发和 提供新的课程和培训计划，强调实施科学以实现影响和公平。我们 将增强我们的混合和在线课程，以改善学员的访问和灵活性并共享材料 与 ICTS 合作伙伴和其他 CTSA 中心合作。 （CTSA 目标：转化型劳动力发展） 2：提供高质量的信息学培训。我们将加强信息学和数据科学培训 （讲习班、研讨会、课程、证书和学位），并整合新的信息学方法、工具和 技能融入我们的课程和培训计划，以满足个人学者的需求。 （CTSA 目标：信息学） 3：扩大领导高影响力、多学科、 临床/转化研究团队。我们将培养来自不同学科的学者、教师和导师 促进从医学（URiM）群体中代表性不足的教师和学者的招募和保留。 为了扩大不同社区和人群在整个生命周期中的高影响力研究，我们将整合 新的团队科学，URiM 专注于我们的课程和职业生涯中的指导和领导力发展 发展计划（CTSA 目标：将特殊人群纳入整个生命周期） 4：加强 KL2 项目中教师、导师和学者之间的合作 利益相关者、ICTS 计划职能部门、合作伙伴和 CTSA 中心。我们将创造新资源，共享 最佳实践，并推进多元化的跨学科科学团队，以促进患者和社区的参与 地方、区域和国家各级的研究和培训。 （CTSA 目标：协作和参与） 5：展示KL2计划的影响。我们将评估短期和长期的表现 学者，确定培训方法的有效性，并利用这些数据来改进培训、受训者和教师 满意度、指导、多样性、领导力和成果。 （CTSA 目标：方法和流程） 项目摘要/摘要页 1137 联系 PD/PI：Powderly, William G. Inst-Career-Dev-001 (463) I. 机构职业发展核心：KL2 部分 9. 参考书目和参考文献 1. Tsevat J，Smyth SS。培训转化人员：超越转化研究 包括转化科学。临床翻译科学杂志。 2020 年 4 月 6 日；4(4):360-362。 PMCID：PMC7681113。 2.Sorkness CA、Scholl L、Fair AM、Umans JG。 KL2 在临床和临床领域指导职业发展计划 转化科学奖励中心：实践和成果。临床翻译科学杂志。 2020 年 2 月；4(1):43-52。 PMCID： PMC7103475。 3. 罗宾逊 GF、施瓦茨 LS、迪梅利奥 LA、阿鲁瓦利亚 JS、加布里洛夫 JL。了解职业成功和 其对临床和转化研究人员的影响因素。医学科学院。 2016 年 4 月；91(4):570-82。 PMCID： PMC4811729。 4. 格雷罗 LR、中园 T、戴维森 PL。 NIH 临床和转化职业发展奖 科学奖励机构：表现最佳的网站的显着特征。临床翻译科学。 2014年 十二月；7(6)：470-5。 PMCID：PMC4361077。 5. Scozzi D, Cano M, Ma L, Zhou D, Zhu JH, O'Halloran JA, Goss C, Rauseo AM, Liu Z, Sahu SK, Peritore V, Rocco M、Ricci A、Amodeo R、Aimati L、Ibrahim M、Hachem R、Kreisel D、Mudd PA、Kulkarni HS、Gelman AE。 循环线粒体 DNA 是 COVID-19 导致的严重疾病和死亡的早期指标。 JCI 洞察力。 2021 年 2 月 22 日；6(4)。 PMCID：PMC7934921。 6. Mody A，Pfeifauf K，耿 EH。使用洛伦兹曲线衡量 COVID-19 测试中的种族不平等。 JAMA 网络公开赛。 2021 年 1 月 4 日；4(1)：e2032696。 PMCID：PMC7794664。 7. Mody A、Lyons PG、Guillamet CV、Michelson A、Yu S、Namwase AS、Sinha P、Powderly WG、Woeltje K、 耿鄂华.美国医院系统中 COVID-19 疾病的临床病程：多州分析。杰姆 流行病。 2020 年 12 月 22 日。PMCID：PMC7799307。 8. Mody A、Pfeifauf K、Bradley C、Fox B、Hlatshwayo MG、Ross W、Sanders-Thompson V、Joynt K、Reidhead M、Schootman M、Powderly WG、Geng EH。了解 COVID-19 种族差异的驱动因素：A 黑人和白人中 COVID-19 检测的人群水平分析。临床感染疾病。 2020年12月 14.PMCID：PMC7799327。 9. https://crtc.wustl.edu/resources/otg。 10. https://icts.wustl.edu/research-services/research-development-program/。 11. Sweeney C、Schwartz LS、Toto R、Merchant C、Fair AS、Gabrilove JL。过渡到独立： 临床和转化领域指导型职业发展（KL2）学者的特征和成果 科学奖励机构。医学科学院。 2017 年 4 月；92(4)：556-562。 PMCID：PMC5373479。 12. Abedin Z、Biskup E、Silet K、Garbutt JM、Kroenke K、Feldman MD、McGee R, Jr.、Fleming M、Pincus HA。 培养临床和转化学者导师的能力。临床翻译科学。 2012 年 6 月；5(3)：273-80。 PMCID：PMC3476465。 13. Keyser DJ、Lakoski JM、Lara-Cinisomo S、Schultz DJ、Williams VL、Zellers DF、Pincus HA。前进 支持研究指导的机构努力：概念框架和自我评估工具。阿卡德 医学。 2008 年 3 月；83(3)：217-25。 14. https://cimerproject.org/entering-mentoring/ 15. Meagher E、Taylor L、Probsfield J、Fleming M。评估临床领域的研究导师 转化科学：文献综述。临床翻译科学。 2011 年 10 月；4(5):353-8。 PMCID：PMC3727275。 16. 近 KA、Nuechterlein BM、Tan S、Zerzan JT、Libby AM、Austin GL。训练导师与学员结对 建立强大的指导文化以及临床和转化研究人员的渠道：科罗拉多州 指导培训计划。医学科学院。 2020 年 5 月；95(5):730-736。 PMCID：PMC7644265。 17. https://crtc.wustl.edu/wp-content/uploads/CRTC_Teaching-with-Technology-Manual.pdf 18. https://www.ahrq.gov/teamstepps/master-training-course.html。 19.Byington CL、Keenan H、Phillips JD、Childs R、Wachs E、Berzins MA、Clark K、Torres MK、Abramson J、Lee V，克拉克 EB。有效支持临床和转化科学家的矩阵指导模型 引用的参考文献第 1138 页