The Role of Vitamin D in Retinal Diseases in Aging

维生素 D 在衰老引起的视网膜疾病中的作用

• 批准号: 8658368
• 负责人: Amy Elizabeth Millen
• 金额: $ 38.99万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658368
• 关键词: 25-hydroxyvitamin D; Accounting; African American; Age related macular degeneration; Aging; Anti-Inflammatory Agents; Anti-inflammatory; Atherosclerosis; Automobile Driving; Biological Assay; Blindness; Blood Glucose; Blood Pressure; Blood specimen; Caucasians; Caucasoid Race; Chronic Disease; Communities; Complement Factor H; Cost Measures; Data; Development; Diabetes Mellitus; Diabetic Retinopathy; Dietary Supplementation; Dietary intake; Disease; Disease Progression; Elderly; Epidemiologic Studies; Exercise; Eye diseases; Genes; Genetic; Goals; Health; Health Care Costs; Incidence; Individual; Lead; Life; Longitudinal Studies; Minority; Participant; Persons; Physical activity; Play; Population; Population Attributable Risks; Prevalence; Prevalence Study; Prevention therapy; Property; Prospective Studies; Quality of life; Reading; Research; Retinal; Retinal Diseases; Risk; Risk Factors; Role; Sampling; Serum; Smoking; Time; United States; Vision; Visit; Vitamin D; Vitamin D Deficiency; Vitamins; Woman; Work; age related; aging population; blood glucose regulation; cohort; cost; follow-up; food preparation; high risk; men; middle age; modifiable risk; population based; prevent; prospective

DESCRIPTION (provided by applicant): The number of aging individuals with the vision threatening diseases of diabetic retinopathy (DR) and age- related macular degeneration (AMD) is projected to increase in the coming decades as the aging population of the United States grows. Identifying new modifiable factors that prevent or delay vision threatening disease is significant because it will reduce the burden of health care costs for treatment of such chronic diseases and extend the years that the elderly can be independent and participate in such vision dependent activities as driving, reading, exercise, and food preparation. Vitamin D deficiency and inadequacy is prevalent in a large portion of the aging US population, and vitamin D has been shown to have anti-inflammatory and anti- angiogenic properties, in addition to potentially modulating blood pressure and glucose control. The long-term goal of the proposed research is to better understand the role of vitamin D status in retinal diseases highly prevalent in aging individuals. Minimal research has investigated the association between vitamin D status and DR; although a strong biologic rationale supports vitamin D status as a potential modifiable risk factor for DR development and progression. At the same time, research in two large epidemiologic studies show that people with vitamin D deficiency or inadequacy (25-hydroxyvitamin D (25(OH)D)<50 nmol/L) are more likely to have prevalent AMD, but no prospective studies of AMD incidence and vitamin D status have been conducted. We hypothesize that individuals with deficient or inadequate vitamin D status, compared to individuals with adequate status, will be more likely to have AMD and DR and be more likely to develop AMD. The purpose of this proposal is to investigate associations between vitamin D status and both DR and AMD using data from the aging (45-64 years) Atherosclerosis Risk in Communities (ARIC) population-based, biracial (African American and Caucasian) cohort. We propose to use previously collected data, including graded retinal photographs for DR and AMD status, and assayed serum 25(OH)D concentrations from ARIC study participants collected from 1987-1995, as well as graded retinal photographs currently being obtained in a follow-up study (2011-2013). Specifically, we propose to investigate the association between vitamin D status, assessed at Visit 2 (1990-1992), and 1) the presence of DR assessed at Visit 3 (1993-1995) among 1,657 individuals with diabetes and 2) the presence of AMD assessed at Visit 3 (1993-1995) among 11,532 participants. Third, we also proposed to investigate, for the first time, the association between vitamin D status, assessed in 1990-1992, and the incidence or progression of AMD (from 1993-1995 to 2011-2013) in a sample of approximately 2,346 ARIC participants. This study will advance our understanding of vitamin D status in relation to common vision-threatening eye diseases in the elderly and could lead to new therapies for the prevention or reduced progression of these diseases.

描述（由申请人提供）：随着未来几十年，随着美国衰老人口的增长，预计糖尿病性视网膜病（DR）和与年龄相关的黄斑变性（AMD）的老龄化患者的数量预计会增加。确定预防或延迟视力威胁疾病的新的可修改因素非常重要，因为它将减轻治疗此类慢性疾病的医疗保健费用的负担，并延长老年人可以独立并参与诸如驾驶，阅读等视力依赖活动的年份，运动和食物准备。维生素D缺乏症和不足性在美国衰老的大部分人群中普遍存在，并且除了可能调节血压和葡萄糖控制外，维生素D除了具有抗炎和抗血管生成特性。拟议的研究的长期目标是更好地了解维生素D状况在视网膜疾病中的作用在老年人中极为普遍。最少的研究调查了维生素D状态与DR之间的关联。尽管强大的生物学原理支持维生素D状态作为DR开发和进展的潜在可修改风险因素。同时，在两项大型流行病学研究中的研究表明，维生素D缺乏症或不足的人（25-羟基维生素D（25（OH）D）<50 nmol/L）更有可能患有AMD，但没有前瞻性研究已经进行了AMD发病率和维生素D状态。我们假设与具有适当地位的个体相比，维生素D状况不足或不足的人更有可能具有AMD和DR，并且更有可能发展AMD。该提案的目的是使用衰老（45 - 64年）动脉粥样硬化风险（ARIC）基于人群的Bidacial，Bidacial（非裔美国人和高加索人）同胞的数据研究维生素D状况与DR和AMD之间的关联。我们建议使用先前收集的数据，包括用于DR和AMD状态的标准视网膜照片，并分析了1987 - 1995年收集的ARIC研究参与者的血清25（OH）D浓度，以及目前在以下内容中获得的分级视网膜照片UP研究（2011-2013）。具体而言，我们建议研究维生素D状态之间的关联，在访问2（1990-1992）和1）1,657名糖尿病患者和2）存在时在访问3（1993-1995）上进行评估的DR的存在和2）在11,532名参与者中，AMD在访问3（1993-1995）上进行了评估。第三，我们还提出了在1990 - 1992年评估的维生素D状态之间的关联，以及在大约2,346个Aric的样本中评估的维生素D状态（从1993- 1995年到2011- 2013年）的AMD的发生率或进展（从1993- 1995年到2011年）。参与者。这项研究将促进我们对老年人威胁性视力疾病有关的维生素D状态的理解，并可能导致预防或降低这些疾病进展的新疗法。

项目成果

Findings from Optometrists' Practices in Advising about Lifestyle Study.

• DOI: 10.1097/opx.0000000000001555
• 发表时间: 2020-08
• 期刊: OPTOMETRY AND VISION SCIENCE
• 影响因子: 1.4
• 作者: Sahli, Michelle W.;Ochs-Balcom, Heather M.;Moeller, Suzen M.;Brady, William E.;Tolford, Timothy W.;Millen, Amy E.
• 通讯作者: Millen, Amy E.