Vitamin D Status and Periodontal Disease

维生素 D 状况与牙周病

基本信息

批准号：
8069542
负责人：
Amy Elizabeth Millen
金额：
$ 19.81万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-05 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8069542
关键词：
25-hydroxyvitamin D Aging Alveolar Ancillary Study Anti-Inflammatory Agents Anti-inflammatory Biological Markers Blood Bone Density Buffaloes Chronic Disease Clinic Clinic Visits Clinical Consumption Cross-Sectional Studies Data Data Set Dental Development Diet Disease Disease Progression Elderly Enrollment Freezing Habits Health Health Services Height Immune Individual Life Style Longitudinal Studies Measures Medical History Nature Observational Study Older Population Oral Oral Examination Oral health Osteoporosis Participant Periodontal Diseases Periodontium Pharmaceutical Preparations Plasma Population Postmenopause Prevalence Prevention Property Recording of previous events Recruitment Activity Research Risk Risk Factors Role Sampling Skeletal bone Time United States Universities Variant Visit Vitamin D Vitamin D Deficiency Woman Women&apos s Health age related aged aging population antimicrobial bone bone health cohort cost design dietary supplements disorder risk follow-up prevent prospective public health relevance

项目摘要

DESCRIPTION (provided by applicant): The population of the United States is aging and the number of elderly with age-related chronic disease, such as periodontal disease, is likely to increase as well. Prevention or delaying the onset of such diseases is one way to reduce the costs incurred by health care services for treatment of chronic disease of the elderly. Maintaining the integrity of the periodontium is of essential importance in older populations as proper dental health enables consumption of a nutritious diet, which in turn helps prevent development of other chronic diseases. Vitamin D deficiency and insufficiency is prevalent in the United States, and the elderly are at a particular increased risk of having low vitamin D status. As vitamin D has been shown to have both immune modulating and anti-microbial properties, in addition to its effects on bone mineral density, it could potentially protect against development and progression of periodontal disease. To date, limited data exists on the role of vitamin D status as a risk factor for periodontal disease, and no data has investigated the effect of vitamin D status, assessed with a blood biomarker, on progression of periodontal disease. The purpose of this proposal is to investigate associations between vitamin D status and periodontal disease in an aging cohort (aged 53-85 years) of postmenopausal women. We will use previously collected data and plasma from a prospective ancillary study on osteoporosis and periodontal disease conducted within the Buffalo clinic center of the Women's Health Initiative Observational Study (WHI OS). The baseline examination of this prospective ancillary study was conducted from 1997-2000 as an addition to the WHI OS 3 year clinic visit. The participants were then recruited again 5 years later for a follow-up exam from 2002-2005. Specifically, this proposal has two main aims: 1) To determine whether vitamin D status, assessed with plasma 25- hydroxyvitamin D (25(OH)D) concentrations, at baseline (1997-2000) is associated with prevalent periodontal disease assessed at baseline among 935 women with stored baseline plasma, and 2) To determine whether vitamin D status, assessed with plasma 25(OH)D concentrations, at baseline is associated with progressive of periodontal disease determined among 694 women attending the 5-year study follow-up (2002-2005) with stored baseline plasma. At both study visits a standardized oral examination was conducted, blood was drawn, and risk factor data specific to periodontal disease were collected. Additionally, at both visits, detailed data on diet, supplement and medication use, and other factors including lifestyle habits and medical history were collected. This dataset contains a uniquely detailed oral examination with information on alveolar crestal bone height (ACH), determined from intraoral radiographs, measures of probing depth (PD) and clinical attachment loss (CAL). This study will advance our understanding of vitamin D status in relation to periodontal disease prevalence and progression. If vitamin D status is determined to be a risk factor, this could potentially have a significant impact on the dental and overall health of aging populations. PUBLIC HEALTH RELEVANCE: Periodontal disease is highly prevalent in the US aging population. Maintaining adequate vitamin D status may have a significant impact on preventing or delaying progression of periodontal disease due to its proposed anti- inflammatory and anti-microbial properties. The main purpose of this study is to investigate associations between prevalent and progressive periodontal disease and vitamin D status in a longitudinal study of aging post-menopausal women.

描述（由申请人提供）：美国的人口正在老龄化，与年龄相关的慢性疾病（例如牙周疾病）的老年人数量也可能增加。预防或延迟这种疾病的发作是降低医疗保健服务为治疗老年人疾病所产生的成本的一种方法。由于适当的牙齿健康能够消耗营养饮食，因此保持牙周的完整性至关重要，这反过来又有助于防止其他慢性疾病的发展。维生素D缺乏症和不足在美国普遍存在，老年人的维生素D状况较低的风险特别增加。由于维生素D已被证明具有免疫调节性和抗微生物特性，除了对骨矿物质密度的影响外，它也可能可以防止牙周疾病的发育和进展。迄今为止，存在有限的数据，即维生素D状态作为牙周疾病的危险因素的作用，并且没有数据研究维生素D状态的影响，该状态对血液生物标志物评估，对牙周疾病的进展。该提案的目的是研究绝经后妇女的老化队列（53 - 85岁）中维生素D状况与牙周疾病之间的关联。我们将使用先前收集的数据和等离子体，该数据对妇女健康计划观察性研究（WHI OS）的水牛诊所中心内进行的有关骨质疏松和牙周疾病的前瞻性辅助研究。这项前瞻性辅助研究的基线检查是从1997 - 2000年进行的，作为WHI OS 3年诊所访问的补充。然后，5年后再次招募参与者参加2002 - 2005年的后续考试。具体而言，该提案具有两个主要目的：1）确定维生素D状态（通过血浆25-羟基维生素D评估）是否在基线时（1997-2000）在基线时与普遍的牙周疾病有关在935名储存基线等离子体的女性中，2）确定维生素D状态是否使用等离子体25（OH）D浓度进行评估，基线时是否与参加5年研究随访的694名妇女中确定的牙周疾病的进行性有关（2002-2005）具有存储的基线等离子体。在两项研究访问时，都进行了标准化的口腔检查，抽血，并收集了特定于牙周疾病的风险因素数据。此外，在两次访问中，都收集了有关饮食，补充剂和药物使用的详细数据，以及其他因素，包括生活方式习惯和病史。该数据集包含一个独特的详细口腔检查，其中包含有关牙槽骨骨高度（ACH）的信息，由口内X光片确定，探测深度（PD）和临床附着损失（CAL）确定。这项研究将促进我们对牙周疾病患病率和进展的维生素D状况的理解。如果确定维生素D状态是危险因素，则可能会对人口衰老的牙齿和整体健康产生重大影响。公共卫生相关性：牙周疾病在美国老龄化中非常普遍。维持适当的维生素D状态可能会对防止或延迟牙周疾病的进展产生重大影响，因为其拟议的抗炎和抗微生物特性。这项研究的主要目的是研究在衰老的绝经后妇女的纵向研究中，流行和进行性牙周疾病与维生素D状况之间的关联。